{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T06:43:52Z","timestamp":1768718632279,"version":"3.49.0"},"reference-count":55,"publisher":"Japanese Association for Laboratory Animal Science","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp. Anim."],"published-print":{"date-parts":[[2012]]},"DOI":"10.1538\/expanim.61.407","type":"journal-article","created":{"date-parts":[[2012,7,25]],"date-time":"2012-07-25T22:37:59Z","timestamp":1343255879000},"page":"407-416","source":"Crossref","is-referenced-by-count":8,"title":["Mucosal Immune Responses in &lt;i&gt;W\/W&lt;sup&gt;v&lt;\/sup&gt;&lt;\/i&gt; and Sl\/Sld Mutant Mice"],"prefix":"10.1538","volume":"61","author":[{"given":"Naoto","family":"Yoshino","sequence":"first","affiliation":[{"name":"Department of Microbiology, Iwate Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Kanno","sequence":"additional","affiliation":[{"name":"Department of Pathology, Iwate Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyomi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Iwate Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Iwate Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigehiro","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Iwate Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"439","reference":[{"key":"1","unstructured":"2. Azuma, T., Dojyo, M., Ito, S., Yamazaki, Y., Miyaji, H., Ito, Y., Suto, H., Kuriyama, M., Kato, T., and Kohli, Y. 1999. Bile reflux due to disturbed gastric movement is a cause of spontaneous gastric ulcer in <i>W\/W<sup>v<\/sup><\/i> mice. Dig. Dis. Sci. 44: 1177&ndash;1183."},{"key":"2","doi-asserted-by":"crossref","unstructured":"4. Breuer, C., Oh, J., Molderings, G.J., Schemann, M., Kuch, B., Mayatepek, E., and Adam, R. 2010. Therapy-refractory gastrointestinal motility disorder in a child with c-kit mutations. World J. Gastroenterol. 16: 4363&ndash;4366.","DOI":"10.3748\/wjg.v16.i34.4363"},{"key":"3","doi-asserted-by":"crossref","unstructured":"5. Chappaz, S., G&auml;rtner, C., Rodewald, H.R., and Finke, D. 2010. Kit ligand and Il7 differentially regulate Peyer&rsquo;s patch and lymph node development. J. Immunol. 185: 3514&ndash;3519.","DOI":"10.4049\/jimmunol.1000665"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/0264-410X(88)90223-X"},{"key":"5","unstructured":"7. Cone, R.A. 2005. Mucus. pp. 49&ndash;72. <i>In<\/i>: Mucosal Immunology, 3rd Ed. (Mestecky, J., Lamm, M.E., McGhee, J.R., Bienenstock, J., Mayer, L., and Strober, W., eds.), Academic Press, San Diego."},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90298-S"},{"key":"7","doi-asserted-by":"crossref","unstructured":"9. Crowe, S.E., Sestini, P., and Perdue, M.H. 1990. Allergic reactions of rat jejunal mucosa. Ion transport responses to luminal antigen and inflammatory mediators. Gastroenterology 99: 74&ndash;82.","DOI":"10.1016\/0016-5085(90)91232-U"},{"key":"8","doi-asserted-by":"crossref","unstructured":"11. Elson, C.O. and Ealding, W. 1984. Generalized systemic and mucosal immunity in mice after mucosal stimulation with cholera toxin. J. Immunol. 132: 2736&ndash;2741.","DOI":"10.4049\/jimmunol.132.6.2736"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90326-T"},{"key":"10","doi-asserted-by":"crossref","unstructured":"13. Fujihashi, K., Staats, H.F., Kozaki, S., and Pascual, D.W. 2007. Mucosal vaccine development for botulinum intoxication. Expert Rev. Vaccines 6: 35&ndash;45.","DOI":"10.1586\/14760584.6.1.35"},{"key":"11","unstructured":"14. Galli, S.J. 1987. New approaches for the analysis of mast cell maturation, heterogeneity, and function. Fed. Proc. 46: 1906&ndash;1914."},{"key":"12","unstructured":"15. Gardner, E.M., Gonzalez, E.W., Nogusa, S., and Murasko, D.M. 2006. Age-related changes in the immune response to influenza vaccination in a racially diverse, healthy elderly population. Vaccine 24: 1609&ndash;1614."},{"key":"13","doi-asserted-by":"crossref","unstructured":"16. Gl&uuml;ck, R., Mischler, R., Durrer, P., F&uuml;rer, E., Lang, A.B., Herzog, C., and Cryz, S.J. Jr. 2000. Safety and immunogenicity of intranasally administered inactivated trivalent virosome-formulated influenza vaccine containing <i>Escherichia coli<\/i> heat-labile toxin as a mucosal adjuvant. J. Infect. Dis. 181: 1129&ndash;1132.","DOI":"10.1086\/315337"},{"key":"14","doi-asserted-by":"crossref","unstructured":"17. Gl&uuml;ck, U., Gebbers, J.O., and Gl&uuml;ck, R. 1999. Phase 1 evaluation of intranasal virosomal influenza vaccine with and without <i>Escherichia coli<\/i> heat-labile toxin in adult volunteers. J. Virol. 73: 7780&ndash;7786.","DOI":"10.1128\/JVI.73.9.7780-7786.1999"},{"key":"15","doi-asserted-by":"crossref","unstructured":"18. Glueck, R. 2001. Pre-clinical and clinical investigation of the safety of a novel adjuvant for intranasal immunization. Vaccine 20: S42&ndash;S44.","DOI":"10.1016\/S0264-410X(01)00292-4"},{"key":"16","doi-asserted-by":"crossref","unstructured":"19. Ha, T.Y., Reed, N.D., and Crowle, P.K. 1986. Immune response potential of mast cell-deficient <i>W\/W<sup>v<\/sup><\/i> mice. Int. Arch. Allergy Appl. Immunol. 80: 85&ndash;94.","DOI":"10.1159\/000234031"},{"key":"17","doi-asserted-by":"crossref","unstructured":"20. Hagiwara, Y., McGhee, J.R., Fujihashi, K., Kobayashi, R., Yoshino, N., Kataoka, K., Etani, Y., Kweon, M.N., Tamura, S., Kurata, T., Takeda, Y., Kiyono, H., and Fujihashi, K. 2003. Protective mucosal immunity in aging is associated with functional CD4<sup>+<\/sup> T cells in nasopharyngeal-associated lymphoreticular tissue. J. Immunol. 170: 1754&ndash;1762.","DOI":"10.4049\/jimmunol.170.4.1754"},{"key":"18","doi-asserted-by":"crossref","unstructured":"21. Hanani, M. and Freund, H.R. 2000. Interstitial cells of Cajal&mdash;their role in pacing and signal transmission in the digestive system. Acta Physiol. Scand. 170: 177&ndash;190.","DOI":"10.1046\/j.1365-201x.2000.00769.x"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1038\/373347a0"},{"key":"20","doi-asserted-by":"crossref","unstructured":"23. Imaoka, K., Miller, C.J., Kubota, M., McChesney, M.B., Lohman, B., Yamamoto, M., Fujihashi, K., Someya, K., Honda, M., McGhee, J.R., and Kiyono, H. 1998. Nasal immunization of nonhuman primates with simian immunodeficiency virus p55<sup><i>gag<\/i><\/sup> and cholera toxin adjuvant induces Th1\/Th2 help for virus-specific immune responses in reproductive tissues. J. Immunol. 161: 5952&ndash;5958.","DOI":"10.4049\/jimmunol.161.11.5952"},{"key":"21","doi-asserted-by":"crossref","unstructured":"25. Jackson, R.J., Fujihashi, K., Xu-Amano, J., Kiyono, H., Elson, C.O., and McGhee, J.R. 1993. Optimizing oral vaccines: induction of systemic and mucosal B-cell and antibody responses to tetanus toxoid by use of cholera toxin as an adjuvant. Infect. Immun. 61: 4272&ndash;4279.","DOI":"10.1128\/IAI.61.10.4272-4279.1993"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12340431"},{"key":"23","doi-asserted-by":"crossref","unstructured":"27. Jawdat, D.M., Albert, E.J., Rowden, G., Haidl, I.D., and Marshall, J.S. 2004. IgE-mediated mast cell activation induces Langerhans cell migration in vivo. J. Immunol. 173: 5275&ndash;5282.","DOI":"10.4049\/jimmunol.173.8.5275"},{"key":"24","doi-asserted-by":"crossref","unstructured":"28. Kitamura, Y. and Go, S. 1979. Decreased production of mast cells in <i>S1\/S1<sup>d<\/sup><\/i> anemic mice. Blood 53: 492&ndash;497.","DOI":"10.1182\/blood.V53.3.492.bloodjournal533492"},{"key":"25","doi-asserted-by":"crossref","unstructured":"29. Kitamura, Y., Go, S., and Hatanaka, K. 1978. Decrease of mast cells in <i>W\/W<sup>v<\/sup><\/i> mice and their increase by bone marrow transplantation. Blood 52: 447&ndash;452.","DOI":"10.1182\/blood.V52.2.447.bloodjournal522447"},{"key":"26","doi-asserted-by":"crossref","unstructured":"31. Kitamura, Y., Sonoda, T., Nakano, T., Hayashi, C., and Asai, H. 1985. Differentiation processes of connective tissue mast cells in living mice. Int. Arch. Allergy Appl. Immunol. 77: 144&ndash;150.","DOI":"10.1159\/000233769"},{"key":"27","doi-asserted-by":"crossref","unstructured":"33. Malysz, J., Thuneberg, L., Mikkelsen, H.B., and Huizinga, J.D. 1996. Action potential generation in the small intestine of W mutant mice that lack interstitial cells of Cajal. Am. J. Physiol. 271: G387&ndash;G399.","DOI":"10.1152\/ajpgi.1996.271.3.G387"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030448"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1038\/ni1005"},{"key":"30","doi-asserted-by":"crossref","unstructured":"36. Moldoveanu, Z. and Fujihashi, K. 2005. Collection and processing of external secretions and tissues of mouse origin. pp. 1841&ndash;1852. <i>In<\/i>: Mucosal Immunology, 3rd Ed. (Mestecky, J., Lamm, M.E., McGhee, J.R., Bienenstock, J., Mayer, L., and Strober, W., eds.), Academic Press, San Diego.","DOI":"10.1016\/B978-012491543-5\/50110-8"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030595"},{"key":"32","doi-asserted-by":"crossref","unstructured":"38. Nakahara, M., Isozaki, K., Hirota, S., Vanderwinden, J.M., Takakura, R., Kinoshita, K., Miyagawa, J., Chen, H., Miyazaki, Y., Kiyohara, T., Shinomura, Y., and Matsuzawa, Y. 2002. Deficiency of KIT-positive cells in the colon of patients with diabetes mellitus. J. Gastroenterol. Hepatol. 17: 666&ndash;670.","DOI":"10.1046\/j.1440-1746.2002.02756.x"},{"key":"33","unstructured":"39. Nakano, T., Kanakura, Y., Nakahata, T., Matsuda, H., and Kitamura, Y. 1987. Genetically mast cell-deficient <i>W\/W <sup>v<\/sup><\/i> mice as a tool for studies of differentiation and function of mast cells. Fed. Proc. 46: 1920&ndash;1923."},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1101\/gad.3.6.816"},{"key":"35","unstructured":"41. Nocka, K., Tan, J.C., Chiu, E., Chu, T.Y., Ray, P., Traktman, P., and Besmer, P. 1990. Molecular bases of dominant negative and loss of function mutations at the murine <i>c-kit<\/i>\/white spotting locus: <i>W<\/i><sup>37<\/sup>, <i>W<\/i><sup>v<\/sup>, <i>W<\/i><sup>41<\/sup> and <i>W<\/i>. EMBO J. 9: 1805&ndash;1813."},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.26.1260"},{"key":"37","doi-asserted-by":"crossref","unstructured":"43. Perdue, M.H., Masson, S., Wershil, B.K., and Galli, S.J. 1991. Role of mast cells in ion transport abnormalities associated with intestinal anaphylaxis. Correction of the diminished secretory response in genetically mast cell-deficient <i>W\/W<sup>v<\/sup><\/i> mice by bone marrow transplantation. J. Clin. Invest. 87: 687&ndash;693.","DOI":"10.1172\/JCI115047"},{"key":"38","doi-asserted-by":"crossref","unstructured":"44. Sanders, K.M., Ord&ouml;g, T., and Ward, S.M. 2002. Physiology and pathophysiology of the interstitial cells of Cajal: from bench to bedside. IV. Genetic and animal models of GI motility disorders caused by loss of interstitial cells of Cajal. Am. J. Physiol. Gastrointest. Liver Physiol. 282: G747&ndash;G756.","DOI":"10.1152\/ajpgi.00362.2001"},{"key":"39","doi-asserted-by":"crossref","unstructured":"45. Sawamoto, T., Haruta, S., Kurosaki, Y., Higaki, K., and Kimura, T. 1997. Prediction of the plasma concentration profiles of orally administered drugs in rats on the basis of gastrointestinal transit kinetics and absorbability. J. Pharm. Pharmacol. 49: 450&ndash;457.","DOI":"10.1111\/j.2042-7158.1997.tb06823.x"},{"key":"40","doi-asserted-by":"crossref","unstructured":"46. Shekels, L.L., Lyftogt, C.T., and Ho, S.B. 1996. Bile acid-induced alterations of mucin production in differentiated human colon cancer cell lines. Int. J. Biochem. Cell Biol. 28: 193&ndash;201.","DOI":"10.1016\/1357-2725(95)00125-5"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1038\/283662a0"},{"key":"42","doi-asserted-by":"crossref","unstructured":"48. Sl&uuml;tter, B., Hagenaars, N., and Jiskoot, W. 2008. Rational design of nasal vaccines. J. Drug Target. 16: 1&ndash;17.","DOI":"10.1080\/10611860701637966"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.9.2975"},{"key":"44","doi-asserted-by":"crossref","unstructured":"51. Tamura, S., Miyata, K., Matsuo, K., Asanuma, H., Takahashi, H., Nakajima, K., Suzuki, Y., Aizawa, C., and Kurata, T. 1996. Acceleration of influenza virus clearance by Th1 cells in the nasal site of mice immunized intranasally with adjuvant-combined recombinant nucleoprotein. J. Immunol. 156: 3892&ndash;3900.","DOI":"10.4049\/jimmunol.156.10.3892"},{"key":"45","doi-asserted-by":"crossref","unstructured":"52. Thuneberg, L. 1982. Interstitial cells of Cajal: intestinal pacemaker cells? Adv. Anat. Embryol. Cell Biol. 71: 1&ndash;130.","DOI":"10.1007\/978-3-642-68417-3_1"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.04.040186.002133"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0029(19991201)47:5<344::AID-JEMT6>3.0.CO;2-1"},{"key":"48","doi-asserted-by":"crossref","unstructured":"55. Ward, S.M., Burns, A.J., Torihashi, S., Harney, S.C., and Sanders, K.M. 1995. Impaired development of interstitial cells and intestinal electrical rhythmicity in steel mutants. Am. J. Physiol. 269: C1577&ndash;C1585.","DOI":"10.1152\/ajpcell.1995.269.6.C1577"},{"key":"49","doi-asserted-by":"crossref","unstructured":"56. Wu, H.Y. and Russell, M.W. 1993. Induction of mucosal immunity by intranasal application of a streptococcal surface protein antigen with the cholera toxin B subunit. Infect. Immun. 61: 314&ndash;322.","DOI":"10.1128\/IAI.61.1.314-322.1993"},{"key":"50","doi-asserted-by":"crossref","unstructured":"57. Yamamoto, M., Briles, D.E., Yamamoto, S., Ohmura, M., Kiyono, H., and McGhee, J.R. 1998. A nontoxic adjuvant for mucosal immunity to pneumococcal surface protein A. J. Immunol. 161: 4115&ndash;4121.","DOI":"10.4049\/jimmunol.161.8.4115"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.10.5267"},{"key":"52","doi-asserted-by":"crossref","unstructured":"59. Yamamoto, T., Watabe, K., Nakahara, M., Ogiyama, H., Kiyohara, T., Tsutsui, S., Tamura, S., Shinomura, Y., and Hayashi, N. 2008. Disturbed gastrointestinal motility and decreased interstitial cells of Cajal in diabetic <i>db\/db<\/i> mice. J. Gastroenterol. Hepatol. 23: 660&ndash;667.","DOI":"10.1111\/j.1440-1746.2008.05326.x"},{"key":"53","doi-asserted-by":"crossref","unstructured":"60. Yokoyama, M., Tatsuta, M., Baba, M., and Kitamura, Y. 1982. Bile reflux: a possible cause of stomach ulcer in nontreated mutant mice of <i>W\/W<sup>v<\/sup><\/i> genotype. Gastroenterology 82: 857&ndash;863.","DOI":"10.1016\/S0016-5085(82)80246-1"},{"key":"54","doi-asserted-by":"crossref","unstructured":"62. Yoshino, N., L&uuml;, F.X., Fujihashi, K., Hagiwara, Y., Kataoka, K., Lu, D., Hirst, L., Honda, M., van Ginkel, F.W., Takeda, Y., Miller, C.J., Kiyono, H., and McGhee, J.R. 2004. A novel adjuvant for mucosal immunity to HIV-1 gp120 in nonhuman primates. J. Immunol. 173: 6850&ndash;6857.","DOI":"10.4049\/jimmunol.173.11.6850"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90302-U"}],"container-title":["Experimental Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/expanim\/61\/4\/61_407\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T17:34:08Z","timestamp":1687628048000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/expanim\/61\/4\/61_407\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":55,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.1538\/expanim.61.407","relation":{},"ISSN":["1341-1357","1881-7122"],"issn-type":[{"value":"1341-1357","type":"print"},{"value":"1881-7122","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}