{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T22:10:08Z","timestamp":1750803008202,"version":"3.41.0"},"reference-count":0,"publisher":"Clujul Medical","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicine and Pharmacy Reports"],"abstract":"<jats:p>Background and aims. Nitro-oxidative stress may have pathophysiologicalconsequences. The study aimed to assess the nitro-oxidative stress, the vascular growthfactor, and metalloproteinase-9 levels in patients with noncirrohic and cirrhotic portalhypertension.Methods. Patients with noncirrhotic portal hypertension (n=50) and cirrhoticportal hypertension (n=50) from the 3rd Medical Clinic in Cluj-Napoca Romania wereprospectively enrolled between October 2004 and October 2006. A control group ofhealthy volunteers (n=50) was also evaluated. Nitro-oxidative stress was assessed bymeasuring serum concentration of nitrites and nitrate, 3-nitrotyrosine, total oxidativestatus, total antioxidant reactivity, and oxidative stress index. Serum vascular growthfactor and matrix metalloproteinase-9 were also determined.Results. Serum nitrites and nitrate levels significantly increased in bothnoncirrhotic (p&lt;0.001) and cirrhotic portal hypertension (p=0.057). 3-nitrotyrosinealso increased in noncirrhotic (p=0.001) and cirrhotic portal hypertension patients(p=0.014). Total oxidative status showed a significant increase in noncirrhotic (p&lt;0.001)and in cirrhotic portal hypertension (p&lt;0.001), but total antioxidant reactivity did not changesignificantly. The oxidative stress index increased in both noncirrhotic (p &lt;0.001) and cirrhoticportal hypertension (p&lt;0.001), as well as the serum vascular growth factor (p=0.005 andp=0.01, respectively). In NCPHT patients serum MMP-9 was significantly lower than inthe healthy controls (p=0.03) and CPHT patients (p=0.05).Conclusion. In patients with noncirrhotic and cirrhotic portal hypertension asignificant systemic nitro-oxidative stress was found, correlated with an increase ofVEGF. MMP-9 decreased in noncirrhotic portal hypertension.<\/jats:p>","DOI":"10.15386\/cjmed-458","type":"journal-article","created":{"date-parts":[[2015,4,30]],"date-time":"2015-04-30T08:16:34Z","timestamp":1430381794000},"page":"140-145","source":"Crossref","is-referenced-by-count":4,"title":["NITRO-OXIDATIVE STRESS, VEGF AND MMP-9 IN PATIENTS WITH CIRRHOTIC AND NON-CIRRHOTIC PORTAL HYPERTENSION"],"prefix":"10.15386","volume":"88","author":[{"given":"Leon Adrian","family":"Muti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alina Elena","family":"P\u00e2rvu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra M","family":"Cr\u0103ciun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolae","family":"Miron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Acalovschi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6100","published-online":{"date-parts":[[2015,4,29]]},"container-title":["Medicine and Pharmacy Reports"],"original-title":[],"link":[{"URL":"https:\/\/medpharmareports.com\/index.php\/mpr\/article\/download\/458\/415","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/medpharmareports.com\/index.php\/mpr\/article\/download\/458\/415","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T21:45:21Z","timestamp":1750801521000},"score":1,"resource":{"primary":{"URL":"https:\/\/medpharmareports.com\/index.php\/mpr\/article\/view\/458"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,29]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,4,29]]}},"URL":"https:\/\/doi.org\/10.15386\/cjmed-458","relation":{},"ISSN":["2668-0572","2602-0807"],"issn-type":[{"type":"electronic","value":"2668-0572"},{"type":"print","value":"2602-0807"}],"subject":[],"published":{"date-parts":[[2015,4,29]]}}}