{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T02:24:03Z","timestamp":1774664643413,"version":"3.50.1"},"reference-count":0,"publisher":"Clujul Medical","issue":"1","license":[{"start":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T00:00:00Z","timestamp":1579737600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicine and Pharmacy Reports"],"abstract":"<jats:p>Background and aims. The incidence of locally acquired hepatitis E has increased in recent years across Europe. There are only few data on hepatitis E in Romania. The purpose of our research was to describe and compare hepatitis E and hepatitis A in adult patients.\r\nMethods. We included all consecutive adult patients with hepatitis E and hepatitis A admitted to the Teaching Hospital of Infectious Diseases, Cluj-Napoca, Romania between January 2017 and August 2019.\r\nResults. Hepatitis E incidence increased in 2018-2019 compared to 2017. The average age in hepatitis E (n=48) patients was 50.6 versus 39.1 years in hepatitis A (n=152, not including 262 minors) and two-thirds of the patients in both groups were men. Compared to hepatitis A, patients with hepatitis E presented significantly less modified AST and ALT, bilirubin, prothrombin index and INR levels. We found more comorbidities in hepatitis E patients adjusted for age and gender. Severe forms were found in 5 (3.3%) hepatitis A patients, compared to 12 (25%) of hepatitis E patients, of which 3 died. Ribavirin treatment was considered in 9 patients with acute-on-chronic hepatitis E, immunosuppression, cancers or neurological manifestations, showing good results.\r\nConclusions. We observed an increased number of hepatitis E cases. Although laboratory results were less modified compared to hepatitis A, we found a higher number of severe hepatitis E cases. Ribavirin treatment seems to be beneficial in patients with preexisting conditions.<\/jats:p>","DOI":"10.15386\/mpr-1487","type":"journal-article","created":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T18:07:32Z","timestamp":1579802852000},"page":"30-38","source":"Crossref","is-referenced-by-count":3,"title":["A comparison of hepatitis E and A in a teaching hospital in Northwestern Romania. Acute hepatitis E \u2013 a mild disease?"],"prefix":"10.15386","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6256-1688","authenticated-orcid":false,"given":"Alexandru","family":"Istrate","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4154-0498","authenticated-orcid":false,"given":"Amanda Lelia","family":"R\u0103dulescu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6100","published-online":{"date-parts":[[2020,1,23]]},"container-title":["Medicine and Pharmacy Reports"],"original-title":[],"link":[{"URL":"https:\/\/medpharmareports.com\/index.php\/mpr\/article\/download\/1487\/2554","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/medpharmareports.com\/index.php\/mpr\/article\/download\/1487\/2554","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T17:20:43Z","timestamp":1750785643000},"score":1,"resource":{"primary":{"URL":"https:\/\/medpharmareports.com\/index.php\/mpr\/article\/view\/1487"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,23]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,1,31]]}},"URL":"https:\/\/doi.org\/10.15386\/mpr-1487","relation":{},"ISSN":["2668-0572","2602-0807"],"issn-type":[{"value":"2668-0572","type":"electronic"},{"value":"2602-0807","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1,23]]}}}