{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:40:25Z","timestamp":1792010425566,"version":"4.4.0"},"reference-count":0,"publisher":"Clujul Medical","issue":"1","license":[{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicine and Pharmacy Reports"],"abstract":"<jats:p>This review offers insight into the complex interplay between cytokines and vitamin D, with focus on its role in systemic lupus erythematosus (SLE) pathogenesis. It offers a helpful resource for researchers and clinicians seeking to better understand and treat SLE and related autoimmune conditions. The pathogenesis of SLE is complex and involves a wide range of cytokines, primarily of the Th2 type; these cytokines mediate hyperactivity in B lymphocytes and antibody production. Notably, vitamin D is found to suppress the activity of critical Th17-related cytokines like IL-23 and IL-6, which is pivotal for Th17 cell development and function. This ultimately leads to reduced IL-17 production, an increase in regulatory T lymphocytes, and subsequent secretion of IL-10. Supplementation with vitamin D is seen to have positive effects on SLE, leading to lower disease activity scores, decreased levels of autoantibodies, and a reduction of fatigue. <\/jats:p>","DOI":"10.15386\/mpr-2752","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T01:42:26Z","timestamp":1737423746000},"page":"13-20","source":"Crossref","is-referenced-by-count":4,"title":["The immunomodulatory potential of vitamin D on Th17 lymphocytes in systemic lupus erythematosus - a literature review"],"prefix":"10.15386","volume":"98","author":[{"given":"Oana Raluca","family":"Predescu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan Cristian","family":"Dinescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina Elena","family":"Bita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alesandra","family":"Florescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anca Emanuela","family":"Musetescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florentin","family":"Vreju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina Lucia","family":"Ciurea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6100","published-online":{"date-parts":[[2025,1,20]]},"container-title":["Medicine and Pharmacy Reports"],"original-title":[],"link":[{"URL":"https:\/\/medpharmareports.com\/index.php\/mpr\/article\/download\/2752\/3262","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/medpharmareports.com\/index.php\/mpr\/article\/download\/2752\/3262","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T14:20:29Z","timestamp":1750774829000},"score":1,"resource":{"primary":{"URL":"https:\/\/medpharmareports.com\/index.php\/mpr\/article\/view\/2752"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,20]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1,31]]}},"URL":"https:\/\/doi.org\/10.15386\/mpr-2752","relation":{},"ISSN":["2668-0572","2602-0807"],"issn-type":[{"value":"2668-0572","type":"electronic"},{"value":"2602-0807","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1,20]]}}}