{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T00:22:09Z","timestamp":1760746929301,"version":"build-2065373602"},"reference-count":0,"publisher":"Clujul Medical","license":[{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Pharm Rep"],"abstract":"<jats:p>Background. High-frequency ultrasound (HFUS) at frequencies &gt;20 MHz is a valuable non-invasive tool for high-resolution skin imaging, enabling quantitative assessment of epidermal and dermal morphology with an axial resolution of 21 \u03bcm. Such precision supports objective monitoring of dermatoses, including psoriasis.\nObjectives. To compare epidermal and dermal measurements of psoriatic lesions using 75 MHz HFUS and histopathology.\nMethods. Thirty psoriatic papules\/plaques were imaged with 75 MHz HFUS (axial resolution: 21 \u03bcm) in patients who were referred for diagnostic biopsy, measuring epidermal thickness and subepidermal hypo-anechoic zone thickness. Lesions were marked for biopsy alignment, and histologic sections were evaluated along the same axis. Spearman\u2019s correlation analyzed agreement between methods.\nResults. Mean epidermal thickness was 220 \u00b1 33 \u03bcm (HFUS) vs. 215 \u00b1 35 \u03bcm (histopathology; R = 0.82, p &lt; 0.01). subepidermal hypo-anechoic zone thickness was 483 \u00b1 97 \u03bcm (HFUS) vs. 448 \u00b1 89 \u03bcm (histopathology; R = 0.88, p &lt; 0.01). No significant inter-method differences were observed.\nConclusion. 75 MHz HFUS correlates strongly with histopathology in measuring psoriatic epidermal and dermal inflammatory changes, supporting its use as a non-invasive tool for therapeutic monitoring.\n\u00a0<\/jats:p>","DOI":"10.15386\/mpr-2878","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T12:44:56Z","timestamp":1760705096000},"source":"Crossref","is-referenced-by-count":0,"title":["Correlation between 75 MHz high-frequency ultrasound and histopathology in psoriatic lesions"],"prefix":"10.15386","author":[{"given":"Ulugbek","family":"Sabirov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avaz","family":"Inoyatov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Artur","family":"Bezugly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6100","published-online":{"date-parts":[[2025,10,17]]},"container-title":["Medicine and Pharmacy Reports"],"original-title":[],"link":[{"URL":"https:\/\/medpharmareports.com\/index.php\/mpr\/article\/download\/2878\/3357","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/medpharmareports.com\/index.php\/mpr\/article\/download\/2878\/3357","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T12:44:56Z","timestamp":1760705096000},"score":1,"resource":{"primary":{"URL":"https:\/\/medpharmareports.com\/index.php\/mpr\/article\/view\/2878"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,17]]},"references-count":0,"URL":"https:\/\/doi.org\/10.15386\/mpr-2878","relation":{},"ISSN":["2668-0572","2602-0807"],"issn-type":[{"value":"2668-0572","type":"electronic"},{"value":"2602-0807","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10,17]]}}}