{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:58:06Z","timestamp":1761897486586,"version":"3.43.0"},"reference-count":29,"publisher":"Vilnius University Press","issue":"1","license":[{"start":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T00:00:00Z","timestamp":1613692800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AML"],"abstract":"<jats:p>Background.\u00a0Ollier disease is the most common nonhereditary type of enchondromatosis. Enchondromas are common, usually benign intraosseous cartilaginous tumors that form near the growth plate cartilage predominantly unilaterally in the metaphyses and diaphyses of tubular bones. They usually affect the long bones of the hand, the humerus, and the tibia, followed by flat bones, such as the pelvis. The estimated prevalence of Ollier disease is 1 in 100,000 and while it is linked with somatic heterozygous mutations in IDH1 or IDH2 genes, exact etiology is unknown. The risk of malignant transformation towards chondrosarcoma is up to 30\u201335% and it is clinically suspected when pain and a rapid increase in the size of the lesions is seen.Case presentations.\u00a0We report two clinical cases of patients diagnosed with Ollier disease. In both cases transformation to chondrosarcoma was observed.Conclusions.\u00a0Ollier disease is a rare disorder, defined by the presence of multiple enchondromas and an asymmetric distribution of the cartilage lesions that can be extremely variable in terms of size, location, age, gender. Constant monitoring of patients is important due to the high risk of malignancy. Because the disease is very rare and the manifestations vary widely, each patient\u2019s case must be evaluated, and the treatment strategy adopted individually.<\/jats:p>","DOI":"10.15388\/amed.2021.28.1.8","type":"journal-article","created":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T00:26:00Z","timestamp":1613694360000},"page":"181-188","source":"Crossref","is-referenced-by-count":3,"title":["Ollier Disease: A Case Series and Literature Review"],"prefix":"10.15388","volume":"28","author":[{"given":"V\u0117tra","family":"Markevi\u010di\u016bt\u0117","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Medein\u0117 \u0160ilen\u0117","family":"Markevi\u010di\u016bt\u0117","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mindaugas","family":"Stravinskas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6097","published-online":{"date-parts":[[2021,2,19]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Caroline S, Harald J. 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Orphanet Journal of Rare Diseases. 2011; 6(2): 1-11. doi: https:\/\/doi.org\/10.1186\/1750-1172-6-2","DOI":"10.1186\/1750-1172-6-2"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Suhil A, et al. Multiple enchondromatosis (Ollier disease). Ann Saudi Med .2009; 29(1): 65-67. doi: https:\/\/doi.org\/10.5144\/0256-4947.2009.65","DOI":"10.5144\/0256-4947.2009.65"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Avinash K, et al. Ollier Disease: Pathogenesis, Diagnosis, and Management. Orthopedics. 2015; 38(6): e497-506. doi: https:\/\/doi.org\/10.3928\/01477447-20150603-58","DOI":"10.3928\/01477447-20150603-58"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Moon, Ji Young et al. VIP (etoposide, ifosfamide, and cisplatin) in patients with previously treated soft tissue sarcoma. 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Ollier's Disease of the Iliac Bone with Sacroiliac Joint Involvement in an Adolescent Patient. Case Reports in Surgery. 2016. 1-4. doi: https:\/\/doi.org\/10.1155\/2016\/4893718","DOI":"10.1155\/2016\/4893718"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1002\/bjs.1800228713","article-title":"Dyschondroplasia (Ollier's disease): with report of a case","volume":"22","author":"Hunter","year":"1935","unstructured":"Hunter D, Wiles P. Dyschondroplasia (Ollier's disease): with report of a case. Br J Surg. 1935; 22:507-519.","journal-title":"Br J Surg"},{"key":"ref15","unstructured":"Casal D, et al. Hand involvement in Ollier disease and Maffucci syndrome: a case series. Orga oficial da socieda de Portugese ad reumatologia - Acta Reumatol Port. 2010;35:375-378."},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"Sadiqi J, et al. Radiographic features of Ollier's disease - two case reports. BMC Medical Imaging. 2017; 17:58. doi: https:\/\/doi.org\/10.1186\/s12880-017-0230-8","DOI":"10.1186\/s12880-017-0230-8"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"D'Angelo L, et al. Ollier disease. Childs Nerv Syst. 2009; 25:647-653. doi: https:\/\/doi.org\/10.1007\/s00381-009-0873-z","DOI":"10.1007\/s00381-009-0873-z"},{"key":"ref18","unstructured":"Wang JP, et al. Ollier disease: two case reports and a review of the literature. Am J Transl Res 2018;10(11):3818-3826."},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"Murphey, et al. Enchondroma versus chondrosarcoma in the appendicular skeleton: differentiating features. Radiographics. 1998; 18:1213-1237. doi: https:\/\/doi.org\/10.1148\/radiographics.18.5.9747616","DOI":"10.1148\/radiographics.18.5.9747616"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"Ferrer-Santacreu EM, et al. Enchondroma versus Chondrosarcoma in Long Bones of Appendicular Skeleton: Clinical and Radiological Criteria-A Follow-Up. Journal of Oncology. 2016: 1-10. doi: https:\/\/doi.org\/10.1155\/2016\/8262079","DOI":"10.1155\/2016\/8262079"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"Crim J, et al. Can imaging criteria distinguish enchondroma from grade 1 chondrosarcoma? European Journal of Radiology. 2015; 84(11): 2222-2230. doi: https:\/\/doi.org\/10.1016\/j.ejrad.2015.06.033","DOI":"10.1016\/j.ejrad.2015.06.033"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"Gelderblom H, et al. The Clinical Approach Towards Chondrosarcoma. The Oncologist 2008; 13:320 -329. doi: https:\/\/doi.org\/10.1634\/theoncologist.2007-0237","DOI":"10.1634\/theoncologist.2007-0237"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"Penna, V., et al. A new approach to partial knee endopsosthesis in primary bone sarcomas. 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