{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T17:21:55Z","timestamp":1740158515718,"version":"3.37.3"},"reference-count":33,"publisher":"Vilnius University Press","issue":"2","license":[{"start":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T00:00:00Z","timestamp":1636329600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AML"],"abstract":"<jats:p>Background:\u00a0Bell\u2019s palsy is the most common cause of peripheral facial palsy. The etiology and treatment of Bell\u2019s palsy are still controversial. Previous studies emphasize the role of herpes simplex and herpes zoster viruses in this ailment. The role of Interleukin-10 (IL-10) in Bell\u2019s palsy is yet unknown, and few studies have shed light on the matter. This study intended to assess the prognostic value of IL-10 and its relation to the intensity of electrodiagnostic abnormalities and evaluate its potential use as a factor for judging the need for medical or surgical interventions.Materials and Methods:\u00a030 patients in the acute phase of Bell\u2019s palsy participated in this study. Peripheral blood samples were obtained for IL-10 assessment within the first 72 hours (before commencing treatment), and a nerve conduction study (NCS) was performed six days after symptom onset.Results:\u00a0There was no significant correlation between IL-10 serum levels and the severity of nerve conduction pathology in Orbicularis oculi and Orbicularis oris muscles. Also, IL-10 serum levels did not show any meaningful relationships with participants\u2019 age, gender, or symptoms.Conclusion:\u00a0The IL-10 serum levels are not relevant to the pathology of Bell\u2019s palsy, and the assessment of IL-10 serum levels cannot be used as an alternative to NCS for evaluating the severity of acute Bell\u2019s palsy.<\/jats:p>","DOI":"10.15388\/amed.2021.28.2.15","type":"journal-article","created":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T14:31:41Z","timestamp":1636381901000},"page":"15","source":"Crossref","is-referenced-by-count":0,"title":["Is There Any Relation between Serum Levels of Interleukin-10 and Neurophysiological Abnormalities in Bell\u2019s Palsy?"],"prefix":"10.15388","volume":"28","author":[{"given":"Mehdi","family":"Maghbooli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdolreza","family":"Esmaeilzadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Karami Zarandi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arezoo","family":"Jafarzadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6688-3219","authenticated-orcid":false,"given":"Sajjad","family":"Biglari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8872-0093","authenticated-orcid":false,"given":"Nazanin","family":"Azizi Shalbaf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Negar","family":"Farhoudi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6097","published-online":{"date-parts":[[2021,11,8]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Rowlands S, Hooper R, Hughes R, Burney P. The epidemiology and treatment of Bell's palsy in the UK. European journal of neurology. 2002 Jan 20;9(1):63-7. https:\/\/doi.org\/10.1046\/ j.1468-1331.2002.00343.x","DOI":"10.1046\/j.1468-1331.2002.00343.x"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Grogan PM, Gronseth GS. Practice parameter: Steroids, acyclovir, and surgery for Bell's palsy (an evidence-based review) Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2001 Apr 10;56(7):830-6. https:\/\/doi.org\/10.1212 \/WNL.56.7.830","DOI":"10.1212\/WNL.56.7.830"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Prim MP, Gavil\u00e1n J. Aetiopathogenesis of Bell's idiopathic peripheral facial palsy. Revista de neurologia. 2001;32(11): 1055-9. https:\/\/doi.org\/10.33588\/rn.3211.2000630","DOI":"10.33588\/rn.3211.2000630"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Campbell KE, Brundage JF. Effects of climate, latitude, and season on the incidence of Bell's palsy in the US Armed Forces, October 1997 to September 1999. American journal of epidemiology. 2002 Jul 1;156(1):32-9. https:\/\/doi.org\/10.1093\/aje\/kwf009","DOI":"10.1093\/aje\/kwf009"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Vahlne, A., Edstr\u00f6m, S., Arstila, P., Beran, M., Ejnell, H., Nyl\u00e9n, O. and Lycke, E. Bell's palsy and herpes simplex virus. Archives of Otolaryngology. 1981 Feb 1;107(2):79-81. https:\/\/doi.org\/10.1001\/archotol.1981.00790380009003","DOI":"10.1001\/archotol.1981.00790380009003"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Aviel A, Ostfeld E, Marshak G, Burstein R, Bentwich Z. Peripheral blood T and B lymphocyte subpopulations in Bell's palsy. Annals of Otology, Rhinology & Laryngology. 1983 Mar;92(2): 187-91. https:\/\/doi.org\/10.1177\/000348948309200218","DOI":"10.1177\/000348948309200218"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Adour, K.K., Ruboyianes, J.M., Trent, C.S., Von Doersten, P.G., Quesenberry Jr, C.P., Byl, F.M. and Hitchcock, T. Bell's palsy treatment with acyclovir and prednisone compared with prednisone alone: a double-blind, randomized, controlled trial. Annals of Otology, Rhinology & Laryngology. 1996 May;105(5):371-8. https:\/\/doi.org\/10.1177\/000348949610500508","DOI":"10.1177\/000348949610500508"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"Unlu Z, Aslan A, Ozbakkaloglu B, Tunger O, Surucuoglu S. Serologic examinations of hepatitis, cytomegalovirus, and rubella in patients with Bell's palsy. American journal of physical medicine & rehabilitation. 2003 Jan 1;82(1):28-32. https:\/\/doi.org\/10.1097\/00002060-200301000-00005","DOI":"10.1097\/00002060-200301000-00005"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Morgan M, Moffat M, Ritchie L, Collacott I, Brown T. Is Bell's palsy a reactivation of varicella zoster virus?. Journal of Infection. 1995 Jan 1;30(1):29-36. https:\/\/doi.org\/10.1097\/01.PHM. 0000043750.75462.67","DOI":"10.1016\/S0163-4453(95)92769-7"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"Kawaguchi, K., Inamura, H., Abe, Y., Koshu, H., Takashita, E., Muraki, Y., Matsuzaki, Y., Nishimura, H., Ishikawa, H., Fukao, A. and Hongo, S. Reactivation of herpes simplex virus type 1 and varicella - zoster virus and therapeutic effects of combination therapy with prednisolone and valacyclovir in patients with Bell's palsy. The Laryngoscope. 2007 Jan;117(1):147-56. https:\/\/doi.org\/10.1097\/01.mlg.0000248737.65607.9e","DOI":"10.1097\/01.mlg.0000248737.65607.9e"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"Nyland H, Naess A. Lymphocyte subpopulations in blood and cerebrospinal fluid from patients with acute Guillain-Barr\u00e9 syndrome. European neurology. 1978;17(5):247-52. https:\/\/doi.org\/10.1159\/000114953","DOI":"10.1159\/000114953"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"Ballantyne JP. The Acute Facial Palsies. Journal of Neurology, Neurosurgery, and Psychiatry. 1978 Dec;41(12):1149. https:\/\/doi.org\/10.1136\/jnnp.41.12.1149","DOI":"10.1136\/jnnp.41.12.1149"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"Loebell E. Untersuchungen \u00fcber die Reizleitungsgeschwindigkeit in Nervus Facialis. Z. Laryng. Rhinol. 1965;44:685. https:\/\/doi.org\/10.1007\/BF00316934","DOI":"10.1007\/BF00316934"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"Tojima H. Measurement of facial nerve conduction velocity and its application to patients with Bell's palsy. Acta Oto-Laryngologica. 1987 Jan 1;104(sup446):36-41. https:\/\/doi.org\/ 10.3109\/00016488709121839","DOI":"10.3109\/00016488709121839"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"Chesler DA, Reiss CS. The role of IFN-\u03b3 in immune responses to viral infections of the central nervous system. Cytokine & growth factor reviews. 2002 Dec 1;13(6):441-54. https:\/\/doi.org\/10.1016\/S1359-6101(02)00044-8","DOI":"10.1016\/S1359-6101(02)00044-8"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"Jonsson L, Alm G, Thomander L. Elevated serum interferon levels in patients with Bell's palsy. Archives of Otolaryngology-Head & Neck Surgery. 1989 Jan 1;115(1):37-40. https:\/\/doi.org\/10.1001\/archotol.1989.0186025003902","DOI":"10.1001\/archotol.1989.01860250039022"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"Aviel A, Hahn T, Levin S, Ostfeld E, Bregman V, Marshak G. Interferon anti-viral system in Bell's palsy. Acta oto-laryngologica. 1983 Jan 1;95(1-4):69-73. https: \/\/doi. org\/10.3109 \/00016488309130917","DOI":"10.3109\/00016488309130917"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"Greco A, Gallo A, Fusconi M, Marinelli C, Macri GF, de Vincentiis M. Bell's palsy and autoimmunity. Autoimmunity reviews. 2012 Dec 1;12(2):323-8. https:\/\/doi.org\/10.1016 \/j.autrev.2012.05.008","DOI":"10.1016\/j.autrev.2012.05.008"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"Y\u0131lmaz M, Tarakc\u0131o\u01e7lu M, Bayaz\u0131t N, Bayaz\u0131t YA, Nam\u0131duru M, Kanl\u0131kama M. Serum cytokine levels in Bell's palsy. Journal of the neurological sciences. 2002 May 15;197(1-2):69-72. https:\/\/doi.org\/10.1016\/S0022-510X(02)00049-7","DOI":"10.1016\/S0022-510X(02)00049-7"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"Eryilmaz A, Basal Y, Tosun A, Omurlu IK, Basak S. The neutrophil to lymphocyte ratios of our pediatric patients with Bell's palsy. International journal of pediatric otorhinolaryngology. 2015 Dec 1;79(12):2374-7. https:\/\/doi.org\/10.1016\/j.ijporl.2015.10.047","DOI":"10.1016\/j.ijporl.2015.10.047"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"Couper KN, Blount DG, Riley EM. IL-10: the master regulator of immunity to infection. The Journal of Immunology. 2008 May 1;180(9):5771-7. https:\/\/doi.org\/10.4049 \/jimmunol. 180.9.5771","DOI":"10.4049\/jimmunol.180.9.5771"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"Beebe AM, Cua DJ, de Waal Malefyt R. The role of interleukin-10 in autoimmune disease: systemic lupus erythematosus (SLE) and multiple sclerosis (MS). Cytokine & growth factor reviews. 2002 Aug 1;13(4-5):403-12. https:\/\/doi.org\/10.1016\/S1359-6101(02)00025-4","DOI":"10.1016\/S1359-6101(02)00025-4"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"Fitzgerald, D.C., Zhang, G.X., El-Behi, M., Fonseca-Kelly, Z., Li, H., Yu, S., Saris, C.J., Gran, B., Ciric, B. and Rostami, A. Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells. Nature immunology. 2007 Dec;8(12):1372. https:\/\/doi.org\/10.1038\/ ni1540","DOI":"10.1038\/ni1540"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"May M, Klein SR, Blumenthal F. Evoked electromyography and idiopathic facial paralysis. Otolaryngology-Head and Neck Surgery. 1983 Dec;91(6):678-85.","DOI":"10.1177\/019459988309100616"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"Jori J, Szekely L, Kiss JG, Toth F. The prognostic value of facial nerve conduction velocity in patients with Bell's palsy. Clinical Otolaryngology & Allied Sciences. 1998 Dec;23(6):520-3. https:\/\/doi.org\/10.1046\/j.1365-2273.1998.2360520.x","DOI":"10.1046\/j.1365-2273.1998.2360520.x"},{"key":"ref25","unstructured":"Kim JW, Seo JC, Jung TY. Genetic polymorphism of interleukin 10 gene and Sasang constitution in Bell's palsy patients. Korean J Oriental Physiol Pathol. 2005 Apr;19:515-9."},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"Volk GF, Klingner C, Finkensieper M, Witte OW, Guntinas-Lichius O. Prognostication of recovery time after acute peripheral facial palsy: a prospective cohort study. BMJ open. 2013 May 1;3(6):e003007. http:\/\/dx.doi.org\/10.1136\/bmjopen-2013-003007","DOI":"10.1136\/bmjopen-2013-003007"},{"key":"ref27","unstructured":"Prakash KM, Raymond AA. The use of nerve conduction studies in determining the short term outcome of Bell's palsy. Medical Journal of Malaysia. 2003 Mar;58(1):69-78. PMID: 14556328."},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"Ceccanti, M., Gabriele, M., Cambieri, C., Frasca, V., Tartaglia, G., Lopergolo, D., Capua, G., Filipo, R., Mancini, P. and Inghilleri, M. 74. Predictive role of neurophysiological features on Bell's palsy. Clinical Neurophysiology. 2013 Nov 1;124(11):e205-6. https:\/\/doi.org\/10.1016\/ j.clinph .2013.06.101","DOI":"10.1016\/j.clinph.2013.06.101"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"Joachims HZ, Bialik V, Eliachar I. Early diagnosis in Bell's palsy. A nerve conduction study. The Laryngoscope. 1980 Oct;90(10):1705-8. https:\/\/doi.org\/10.1288\/00005537-198010000 -00015","DOI":"10.1288\/00005537-198010000-00015"},{"key":"ref30","doi-asserted-by":"publisher","unstructured":"Kim SH, Ryu EW, Yang CW, Yeo SG, Park MS, Byun JY. The prognostic value of electroneurography of Bell's palsy at the orbicularis oculi versus nasolabial fold. The Laryngoscope. 2016 Jul;126(7):1644-8. https:\/\/doi.org\/10.1002\/lary.25709","DOI":"10.1002\/lary.25709"},{"key":"ref31","doi-asserted-by":"publisher","unstructured":"Fujiwara T, Hato N, Gyo K, Yanagihara N. Prognostic factors of Bell's palsy: prospective patient collected observational study. European Archives of Oto-Rhino-Laryngology. 2014 Jul 1;271(7):1891-5. https:\/\/doi.org\/10.1007\/s00405-013-2676-9","DOI":"10.1007\/s00405-013-2676-9"},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"Mehvari J. The role of electrodiagnosis (EMG, EEMG) and taste sense in diagnosis and prognosis of Bell's palsy. 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