{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:07:19Z","timestamp":1755216439890,"version":"3.43.0"},"reference-count":28,"publisher":"Vilnius University Press","issue":"2","license":[{"start":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T00:00:00Z","timestamp":1669075200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AML"],"abstract":"<jats:p>Aim: The aim is to evaluate the pregnancy outcomes of patients with uterus unicornis for 5-year experience in a tertiary center.\u00a0\r\nMaterial &amp; Method: Twenty patients with uterus unicornis who were diagnosed with hysterosalpingography and\/or 3D TVUSG between 2017 and 2021 and then confirmed with laparoscopy and simultaneous hysteroscopy were recruited for this retrospective study. The reproductive outcome and obstetric complications of the patients were followed up for two years postoperative period.\u00a0\r\nResults: Overall 20 patients who fulfilled the inclusion criterion were recruited for the study. The mean age was 28.65\u00b15.03 years. Thirteen patients (65%) had primary infertility while the remaining seven had secondary infertility with two of them having a previous ectopic pregnancy. Rudimentary communicating uterine horn was observed in 7 (35%) of the patients. The horns were excised during laparoscopy. Overall, 14 (70%) pregnancies were achieved during the 2 years follow-up period. Twelve (85.7%) patients had a live birth, (71.4% term delivery, 21.4% preterm delivery), and two had a first-trimester spontaneous abortion (15.3%). Six (50%) of 12 patients who had a live birth received tocolytics for preterm labor.\u00a0\r\nConclusion: Unicorn uterus is a rare anomaly diagnosed mostly during infertility work-out and might be related to the poor obstetric outcome, but early diagnosis is important for successful pregnancy results for preterm delivery especially in the secondary infertile group. In addition, rudimentary horn excision is recommended due to the high risk of obstetric complications.<\/jats:p>","DOI":"10.15388\/amed.2022.29.2.14","type":"journal-article","created":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T03:06:07Z","timestamp":1669086367000},"page":"207-215","source":"Crossref","is-referenced-by-count":0,"title":["Reproductive Outcome of the Patients with Uterus Unicornis: Five Year Experience in a Tertiary Center"],"prefix":"10.15388","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5711-3933","authenticated-orcid":false,"given":"Sule","family":"Atalay Mert","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1137-8650","authenticated-orcid":false,"given":"Berna","family":"Dilbaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ece Sevin","family":"Cukurova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caner","family":"Kose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaprak","family":"Engin Ustun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6097","published-online":{"date-parts":[[2022,11,22]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Grimbizis GF, Gordts S, Di A, et al. The ESHRE\/ESGE consensus on the classification of female genital tract congenital anomalies. Human Reproduction. 2013;28(8):2032-2044. https:\/\/doi.org\/10.1093\/humrep\/det098","DOI":"10.1093\/humrep\/det098"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"2. Akdemir A, Ergenoglu AM, Yeniel A\u00d6, et al. Coring-type laparoscopic resection of a cavitated non-communicating rudimentary horn under hysteroscopic assistance. J Obstet Gynaecol Res. 2014;40(7):1950-1954. https:\/\/doi.org\/10.1111\/JOG.12449","DOI":"10.1111\/jog.12449"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"3. Sawada M, Kakigano A, Matsuzaki S, et al. Obstetric outcome in patients with a unicornuate uterus after laparoscopic resection of a rudimentary horn. J Obstet Gynaecol Res. 2018;44(6):1080-1086. https:\/\/doi.org\/10.1111\/JOG.13622","DOI":"10.1111\/jog.13622"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"4. Chan YY, Jayaprakasan K, Zamora J, et al. The prevalence of congenital uterine anomalies in unselected and high-risk populations: a systematic review. Hum Reprod Update. 2011;17(6):761-771. https:\/\/doi.org\/10.1093\/HUMUPD\/DMR028","DOI":"10.1093\/humupd\/dmr028"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"5. Perrotin F, Bertrand J, Body G. Laparoscopic surgery of unicornuate uterus with rudimentary uterine horn. Human Reproduction. 1999;14(4):931-933. https:\/\/doi.org\/10.1093\/humrep\/14.4.931","DOI":"10.1093\/humrep\/14.4.931"},{"key":"ref5","unstructured":"6. Schattman GL, Grifo JA, Birnbaum S. Laparoscopic resection of a noncommunicating rudimentary uterine horn. A case report. J Reprod Med. 1995;40(3):219-220. https:\/\/pubmed.ncbi.nlm.nih.gov\/7776307\/"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"7. Caserta D, Mallozzi M, Meldolesi C, et al. Pregnancy in a unicornuate uterus: A case report. J Med Case Rep. 2014;8:130. https:\/\/doi.org\/10.1186\/1752-1947-8-130","DOI":"10.1186\/1752-1947-8-130"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"8. Samuels TA, Awonuga A. Second-trimester rudimentary uterine horn pregnancy: rupture after labor induction with misoprostol. Obstetrics and gynecology. 2005;106(5 Pt 2):1160-1162. https:\/\/doi.org\/10.1097\/01.AOG.0000182989.06439.68","DOI":"10.1097\/01.AOG.0000182989.06439.68"},{"key":"ref8","unstructured":"9. Zou YQ, Chen XX, Feng Y. Clinical study on perinatal outcomes of 80 cases with unicornuate uterus pregnancy. Chin J Obstet Gynecol. 2020;55(8):510-515. https:\/\/doi.org\/10.3760\/CMA.J.CN112141-20200107-00019"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"10. Grimbizis GF, di Spiezio Sardo A, Saravelos SH, et al. The Thessaloniki ESHRE\/ESGE consensus on diagnosis of female genital anomalies. Human Reproduction. 2016;31(1):2-7. https:\/\/doi.org\/10.1093\/HUMREP\/DEV264","DOI":"10.1093\/humrep\/dev264"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"11. Kier R. Magnetic resonance imaging of the uterus. Magn Reson Imaging Clin N Am. 1994;2(2):189-210. https:\/\/pubmed.ncbi.nlm.nih.gov\/7489285\/","DOI":"10.1016\/S1064-9689(21)00341-X"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"12. Fielding JR. MR imaging of the female pelvis. Radiologic Clinics. 2003;41(1):179-192. https:\/\/doi.org\/10.1016\/S0033-8389(02)00063-5","DOI":"10.1016\/S0033-8389(02)00063-5"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"13. al Hakeem M, Siddiq MM, al Nuaim L, Gourab S. Unicornuate uterus with a non-communicating functioning rudimentary horn, associated with ipsilateral renal agensis. Ann Saudi Med. 2004;24(1):48-49. https:\/\/doi.org\/10.5144\/0256-4947.2004.48","DOI":"10.5144\/0256-4947.2004.48"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"14. Reichman D, Laufer MR, Robinson BK. Pregnancy outcomes in unicornuate uteri: a review. Fertil Steril. 2009;91(5):1886-1894. https:\/\/doi.org\/10.1016\/J.FERTNSTERT.2008.02.163","DOI":"10.1016\/j.fertnstert.2008.02.163"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"15. Zhang L, Wang X. Clinical outcomes analysis of infertile women with unicornuate uterus in IVF-ET. J Gynecol Obstet Hum Reprod. 2021;50(7):102111. https:\/\/doi.org\/10.1016\/J.JOGOH.2021.102111","DOI":"10.1016\/j.jogoh.2021.102111"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"16. Liu J, Wu Y, Xu S, et al. Retrospective evaluation of pregnancy outcomes and clinical implications of 34 Han Chinese women with unicornuate uterus who received IVF-ET or ICSI-ET treatment. Journal of Obstetrics and Gynaecology. 2017;37(8):1020-1024. https:\/\/doi.org\/10.1080\/01443615.2017.1318266","DOI":"10.1080\/01443615.2017.1318266"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"17. Chan YY, Jayaprakasan K, Zamora J, et al. The prevalence of congenital uterine anomalies in unselected and high-risk populations: a systematic review. Hum Reprod Update. 2011;17(6):761-771. https:\/\/doi.org\/10.1093\/HUMUPD\/DMR028","DOI":"10.1093\/humupd\/dmr028"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"18. Raga F, Bauset C, Remohi J, et al. Reproductive impact of congenital M\u00fcllerian anomalies. Human Reproduction. 1997;12(10):2277-2281. https:\/\/doi.org\/10.1093\/HUMREP\/12.10.2277","DOI":"10.1093\/humrep\/12.10.2277"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"19. Chen Y, Nisenblat V, Yang P, et al. Reproductive outcomes in women with unicornuate uterus undergoing in vitro fertilization: A nested case-control retrospective study. Reproductive Biology and Endocrinology. 2018;16:64. https:\/\/doi.org\/10.1186\/S12958-018-0382-6","DOI":"10.1186\/s12958-018-0382-6"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"20. Yang C, Huang D, Yang J, et al. Successful delivery of unicornuate uterus pregnancy after laparoscopic cervical cerclage: A case report. Laparosc Endosc Robot Surg. 2021;4(4):125-127. https:\/\/doi.org\/10.1016\/J.LERS.2021.11.001","DOI":"10.1016\/j.lers.2021.11.001"},{"key":"ref20","unstructured":"21. Wanyoike Gichuhi J, Parkar R, Ondieki DK. Endometriosis in unicornuate uterus with non-communicating rudimentary horn. East Afr Med J. 2015;92(10):507-511. https:\/\/doi.org\/10.4314\/eamj.v92i10"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"22. Lallar M, Nandal R, Sharma D. Unruptured rudimentary horn pregnancy presenting with acute haemoperitoneum with combined intrauterine pregnancy: A case report. Iran J Reprod Med. 2015;13(1):49-52. https:\/\/pubmed.ncbi.nlm.nih.gov\/25653676\/","DOI":"10.1136\/bcr-2014-208874"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"23. Contreras KR, Rothenberg JM, Kominiarek MA, Raff GJ. Hand-assisted Laparoscopic Management of a Midtrimester Rudimentary Horn Pregnancy with Placenta Increta: A Case Report and Literature Review. J Minim Invasive Gynecol. 2008;15(5):644-648. https:\/\/doi.org\/10.1016\/J.JMIG.2008.06.008","DOI":"10.1016\/j.jmig.2008.06.008"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"24. Isono W, Tsuchiya A, Honda M, et al. Successful Management of a Noncommunicating Rudimentary Uterine Horn Pregnancy by Laparoscopic Surgery: A Case Report and Literature Review. Gynecol Minim Invasive Ther. 2022;11(1):7-16. https:\/\/doi.org\/10.4103\/GMIT.GMIT_157_20","DOI":"10.4103\/GMIT.GMIT_157_20"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"25. Barnts LH, Kratochvil TJ, Ziegenbein SJ. Tubal pregnancy in a case of unicornuate uterus with contralateral streak ovary and renal agenesis: A case report. Case Rep Womens Health. 2022;34:e00407. https:\/\/doi.org\/10.1016\/J.CRWH.2022.E00407","DOI":"10.1016\/j.crwh.2022.e00407"},{"key":"ref25","unstructured":"26. Henriet E, Roman H, Zanati J, et al. Pregnant Noncommunicating Rudimentary Uterine Horn with Placenta Percreta. JSLS. 2008;12(1):101-103. https:\/\/pubmed.ncbi.nlm.nih.gov\/18402750\/"},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"27. Hussain A, Jawaid H, Faisal N, et al. Ruptured Rudimentary Horn Pregnancy Revealed on Emergency Laparotomy: A Case of Primigravida Presenting in a Developing Country. Cureus. 2018;10(5):e2591. https:\/\/doi.org\/10.7759\/CUREUS.2591","DOI":"10.7759\/cureus.2591"},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"28. Monacci F, Lanfredini N, Zandri S, et al. Diagnosis and laparoscopic management of a 5-week ectopic pregnancy in a rudimentary uterine horn: A case report. Case Rep Womens Health. 2019;21:e00088. https:\/\/doi.org\/10.1016\/J.CRWH.2018.E00088","DOI":"10.1016\/j.crwh.2018.e00088"}],"container-title":["Acta medica Lituanica"],"original-title":[],"link":[{"URL":"https:\/\/www.zurnalai.vu.lt\/AML\/article\/download\/27865\/28862","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.journals.vu.lt\/AML\/article\/download\/27865\/28863","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.zurnalai.vu.lt\/AML\/article\/download\/27865\/28863","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.zurnalai.vu.lt\/AML\/article\/download\/27865\/28862","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T09:56:07Z","timestamp":1754301367000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.zurnalai.vu.lt\/AML\/article\/view\/27865"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,22]]},"references-count":28,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,7,25]]}},"URL":"https:\/\/doi.org\/10.15388\/amed.2022.29.2.14","relation":{},"ISSN":["2029-4174","1392-0138"],"issn-type":[{"type":"electronic","value":"2029-4174"},{"type":"print","value":"1392-0138"}],"subject":[],"published":{"date-parts":[[2022,11,22]]}}}