{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T05:00:24Z","timestamp":1747198824189,"version":"3.40.5"},"reference-count":43,"publisher":"Vilnius University Press","issue":"1","license":[{"start":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T00:00:00Z","timestamp":1716508800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AML"],"abstract":"<jats:p>Background:\u00a0Bloodstream infections are a serious public health problem that requires follow-up with blood culture; this negatively affects the course of the disease and patient healthcare costs in patients with malignancy. This study aimed to determine the growth frequency of pathogens and their antibiotic resistance profiles in the blood cultures of patients with hematological and oncogenic malignancies.Materials and methods:\u00a0The results of 7451 blood cultures, obtained from 2926 patients between January 2017 and January 2022, were evaluated retrospectively. Of these cultures, 3969 were obtained from patients with malignancy (diagnostic codes C00-D48 in ICD-10) and 3482 from patients without malignancy. The hospital information management system modules were used to acquire patient data and blood culture results.Results:\u00a0Various microorganisms grew in 10.1% of blood cultures. Of these organisms, 64.1% were isolated from cases of malignancy. Of the pathogens, 49.2% were gram-negative bacteria, 47.7% were gram-positive bacteria, and 3.1% were fungi. The most frequently isolated bacteria were methicillin-resistant coagulase-negative staphylococci (3.2%),\u00a0Escherichia coli\u00a0(2.3%),\u00a0Klebsiella pneumoniae\u00a0(1.0%), methicillin-sensitive coagulase-negative staphylococci (0.7%), and\u00a0Staphylococcus aureus\u00a0(0.6%). Pathogen positivity was highest in the patient cultures with urinary system cancer (23.9%), thyroid and other endocrine gland cancers (20.6%), female and male genital organ cancers (18.2%\/16.9%), and digestive organ cancer (14.2%). Gram-negative bacteria to ampicillin, piperacillin, and sulfamethoxazole-trimethoprim and Gram-positive bacteria to penicillin, erythromycin, and sulfamethoxazole-trimethoprim were highly resistant. Combined resistance to imipenem and meropenem was observed in 25 Gram-negative bacteria. Twelve (48%) of the carbapenem-resistant bacteria were isolated from patients with lymphoid, hematopoietic, and related tissue malignant neoplasia.Conclusion:\u00a0This study reported microorganisms and their antimicrobial resistance in the blood cultures of malignant patients, a special patient group. It pointed out that the antibiotic resistance of\u00a0Staphylococcus, Klebsiella pneumoniae, and\u00a0E. coli\u00a0is high enough to cause problems in the treatment of patients with malignancy.<\/jats:p>","DOI":"10.15388\/amed.2024.31.1.17","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T03:45:04Z","timestamp":1716522304000},"page":"65-76","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Blood Culture Results in Patients with Malignancy in Erzurum Province, Turkey"],"prefix":"10.15388","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7762-4108","authenticated-orcid":false,"given":"Osman","family":"Aktas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0413-5634","authenticated-orcid":false,"given":"Ozg\u00fcr","family":"Akbaba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0759-9832","authenticated-orcid":false,"given":"Muhammet Hamidullah","family":"Uyanik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1478-7441","authenticated-orcid":false,"given":"Hakan","family":"Uslu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6097","published-online":{"date-parts":[[2024,5,24]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Liu J, Luo F, Wen L, Zhao Z, Sun H. Current Understanding of Microbiomes in Cancer Metastasis. Cancers. 2023;15(6):1893. https:\/\/doi.org\/10.3390\/cancers15061893","DOI":"10.3390\/cancers15061893"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Mohammed MA, Lakhan A, Abdulkareem KH, Garcia-Zapirain B. A hybrid cancer prediction based on multi-omics data and reinforcement learning state action reward state action (SARSA). Comput Biol Med. 2023;154:106617. https:\/\/doi.org\/10.1016\/j.compbiomed.2023.106617","DOI":"10.1016\/j.compbiomed.2023.106617"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Kube\u010dek O, Paterov\u00e1 P, Novosadov\u00e1 M. Risk factors for infections, antibiotic therapy, and its impact on cancer therapy outcomes for patients with solid tumors. Life (Basel). 2021;11(12):1387. https:\/\/doi.org\/10.3390\/life11121387","DOI":"10.3390\/life11121387"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Da Silva R, Casella T. Healthcare-associated infections in patients who are immunosuppressed due to chemotherapy treatment: a narrative review. J Infect Dev Ctries. 2022;16(12):1784-1795. https:\/\/doi.org\/10.3855\/jidc.16495","DOI":"10.3855\/jidc.16495"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Matsuda A, Maruyama H, Akagi S, et al. Do postoperative infectious complications really affect long-term survival in colorectal cancer surgery? A multicenter retrospective cohort study. Ann Gastroenterol Surg. 2022;7(1):110-120. https:\/\/doi.org\/10.1002\/ags3.12615","DOI":"10.1002\/ags3.12615"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Islas-Mu\u00f1oz B, Volkow-Fern\u00e1ndez P, Ibanes-Guti\u00e9rrez C, Villamar-Ram\u00edrez A, Vilar-Compte D, Cornejo-Ju\u00e1rez P. Bloodstream infections in cancer patients. Risk factors associated with mortality. Int J Infect Dis. 2018;71:59-64. https:\/\/doi.org\/10.1016\/j.ijid.2018.03.022","DOI":"10.1016\/j.ijid.2018.03.022"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Amanati A, Sajedianfard S, Khajeh S, et al. Bloodstream infections in adult patients with malignancy, epidemiology, microbiology, and risk factors associated with mortality and multi-drug resistance. BMC Infect Dis. 2021;21(1):636. https:\/\/doi.org\/10.1186\/s12879-021-06243-z","DOI":"10.1186\/s12879-021-06243-z"},{"key":"ref7","unstructured":"K\u0142os M, W\u00f3jkowska-Mach J. Hospital-acquired Enterobacteriaceae bloodstream infections in children. Dev Period Med. 2019;23(2):131-136. https:\/\/doi.org\/10.34763\/devperiodmed.20192302.131136"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Islas-Mu\u00f1oz B, Volkow-Fern\u00e1ndez P, Ibanes-Guti\u00e9rrez C, Villamar-Ram\u00edrez A, Vilar-Compte D, Cornejo-Ju\u00e1rez P. Bloodstream infections in cancer patients. Risk factors associated with mortality. Int J Infect Dis. 2018;71:59-64. https:\/\/doi.org\/10.1016\/j.ijid.2018.03.022","DOI":"10.1016\/j.ijid.2018.03.022"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"Alemnew B, Biazin H, Demis A, Abate Reta M. Bacterial profile among patients with suspected bloodstream infections in Ethiopia: a systematic review and meta-analysis. Int J Microbiol. 2020;2020:8853053. https:\/\/doi.org\/10.1155\/2020\/8853053","DOI":"10.1155\/2020\/8853053"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"1Hollenberg SM, Singer M. Pathophysiology of sepsis-induced cardiomyopathy. Nat Rev Cardiol. 2021;18(6):424-434. https:\/\/doi.org\/10.1038\/s41569-020-00492-2","DOI":"10.1038\/s41569-020-00492-2"},{"key":"ref11","unstructured":"Chela HK, Vasudevan A, Rojas-Moreno C, Naqvi SH. Approach to positive blood cultures in the hospitalized patient: a review. Mo Med. 2019;116(4):313-317."},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"Meryk A, Kropshofer G, Bargehr C, et al. Which type of empiric antibiotic therapy is appropriate? A 20-year retrospective study of bloodstream infections in childhood cancer. Infect Dis Ther. 2021;10(2):789-800. https:\/\/doi.org\/10.1007\/s40121-021-00427-5","DOI":"10.1007\/s40121-021-00427-5"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"Baier C, Linke L, Eder M, et al. Incidence, risk factors and healthcare costs of central line-associated nosocomial bloodstream infections in hematologic and oncologic patients. PLoS One. 2020;15(1):e0227772. https:\/\/doi.org\/10.1371\/journal.pone.0227772","DOI":"10.1371\/journal.pone.0227772"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"Allen PB, Switchenko J, Ayers A, Kim E, Lechowicz MJ. Risk of bacteremia in patients with cutaneous T-cell lymphoma (CTCL). Leuk Lymphoma. 2020;61(11):2652-2658. https:\/\/doi.org\/10.1080\/10428194.2020.1779259","DOI":"10.1080\/10428194.2020.1779259"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"Di Franco S, Alfieri A, Pace MC, Sansone P, Pota V, Fittipaldi C, et al. Blood stream infections from MDR bacteria. Life (Basel). 2021;11(6):575. https:\/\/doi.org\/10.3390\/life11060575","DOI":"10.3390\/life11060575"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"Lubwama M, Phipps W, Najjuka CF, et al. Bacteremia in febrile cancer patients in Uganda. BMC Res Notes. 2019;12(1):464. https:\/\/doi.org\/10.1186\/s13104-019-4520-9","DOI":"10.1186\/s13104-019-4520-9"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"Wiggers JB, Xiong W, Daneman N. Sending repeat cultures: is there a role in the management of bacteremic episodes? (SCRIBE study). BMC Infect Dis. 2016;16:286. https:\/\/doi.org\/10.1186\/s12879-016-1622-z","DOI":"10.1186\/s12879-016-1622-z"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"Horan TC, Andrus M, Dudeck MA. CDC\/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control. 2008;36(5):309-332. https:\/\/doi.org\/10.1016\/j.ajic.2008.03.002","DOI":"10.1016\/j.ajic.2008.03.002"},{"key":"ref19","unstructured":"The European Committee on Antimicrobial Susceptibility Testing. Breakpoint tables for interpretation of MICs and zone diameters. Version 7.1, 2017. Accessed January 15, 2022. http:\/\/www.eucast.org"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"B\u00f6ll B, Schalk E, Buchheidt D, et al. Central venous catheter-related infections in hematology and oncology: 2020 updated guidelines on diagnosis, management, and prevention by the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO). Ann Hematol. 2021;100(1):239-259. https:\/\/doi.org\/10.1007\/s00277-020-04286-x","DOI":"10.1007\/s00277-020-04286-x"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"Jiang AM, Liu N, Ali Said R, et al. Nosocomial infections in gastrointestinal cancer patients: bacterial profile, antibiotic resistance pattern, and prognostic factors. Cancer Manag Res. 2020;12:4969-4979. https:\/\/doi.org\/10.2147\/CMAR.S258774","DOI":"10.2147\/CMAR.S258774"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"Jayaweera JAAS, Sivakumar D. Asymptomatic central line-associated bloodstream infections in children implanted with long term indwelling central venous catheters in a teaching hospital, Sri Lanka. BMC Infect Dis. 2020;20(1):457. https:\/\/doi.org\/10.1186\/s12879-020-05190-5","DOI":"10.1186\/s12879-020-05190-5"},{"key":"ref23","unstructured":"T\u00fcrkiye Cumhuriyeti Sa\u011fl\u0131k Bakanl\u0131\u011f\u0131 Halk Sa\u011fl\u0131\u011f\u0131 Genel M\u00fcd\u00fcrl\u00fc\u011f\u00fc. T\u00fcrkiye Kanser \u0130statistikleri 2018, Ankara, 2022. Accessed December 11, 2023. https:\/\/hsgm.saglik.gov.tr\/tr\/kanser-istatistikleri"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"Leibovici-Weissman Y, Tau N, Yahav D. Bloodstream infections in the elderly: what is the real goal? Aging Clin Exp Res. 2021;33(4):1101-1112. https:\/\/doi.org\/10.1007\/s40520-019-01337-w","DOI":"10.1007\/s40520-019-01337-w"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"Uslan DZ, Crane SJ, Steckelberg JM, et al. Age- and sex-associated trends in bloodstream infection: a population-based study in Olmsted County, Minnesota. Arch Intern Med. 2007;167(8):834-839. https:\/\/doi.org\/10.1001\/archinte.167.8.834","DOI":"10.1001\/archinte.167.8.834"},{"key":"ref26","unstructured":"Y\u0131lmaz M. The Change of the structure and educational status of population in Erzurum province that has been occurred in quarter Century (1990-2015). Marmara Geographical Review. 2017;36:162-174."},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"Royo-Cebrecos C, Gudiol C, Ardanuy C, Pomares H, Calvo M, Carratal\u00e0 J. A fresh look at polymicrobial bloodstream infection in cancer patients. PLoS One. 2017;12(10):e0185768. https:\/\/doi.org\/10.1371\/journal.pone.0185768","DOI":"10.1371\/journal.pone.0185768"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"Siddiqui B, Azmat R, Tikmani SS, et al. Frequency of bloodstream infection in febrile neutropenic patients, experience from a developing country. Ann Med Surg. 2018;34:71-74. https:\/\/doi.org\/10.1016\/j.amsu.2018.09.004","DOI":"10.1016\/j.amsu.2018.09.004"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"Farkas A, Tarco E, Butiuc-Keul A. Antibiotic resistance profiling of pathogenic Enterobacteriaceae from Cluj-Napoca, Romania. Germs. 2019;9(1):17-27. https:\/\/doi.org\/10.18683\/germs.2019.1153","DOI":"10.18683\/germs.2019.1153"},{"key":"ref30","doi-asserted-by":"publisher","unstructured":"Song W, Park MJ, Jeong S, et al. Rapid identification of OXA-48-like, KPC, NDM, and VIM carbapenemase-producing Enterobacteriaceae from culture: evaluation of the RESIST-4 O.K.N.V. multiplex lateral flow assay. Ann Lab Med. 2020;40(3):259-263. https:\/\/doi.org\/10.3343\/alm.2020.40.3.259","DOI":"10.3343\/alm.2020.40.3.259"},{"key":"ref31","doi-asserted-by":"publisher","unstructured":"Leclercq R, Cant\u00f3n R, Brown DF, et al. EUCAST expert rules in antimicrobial susceptibility testing. Clin Microbiol Infect. 2013;19(2):141-160. https:\/\/doi.org\/10.1111\/j.1469-0691.2011.03703.x","DOI":"10.1111\/j.1469-0691.2011.03703.x"},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"Enoch DA, Birkett CI, Ludlam HA. Non-fermentative Gram-negative bacteria. Int J Antimicrob Agents. 2007;29 Suppl 3:S33-S41. https:\/\/doi.org\/10.1016\/S0924-8579(07)72176-3","DOI":"10.1016\/S0924-8579(07)72176-3"},{"key":"ref33","doi-asserted-by":"publisher","unstructured":"Karaman R, Jubeh B, Breijyeh Z. Resistance of Gram-positive bacteria to current antibacterial agents and overcoming approaches. Molecules. 2020;25(12):2888. https:\/\/doi.org\/10.3390\/molecules25122888","DOI":"10.3390\/molecules25122888"},{"key":"ref34","doi-asserted-by":"publisher","unstructured":"Marincola G, Liong O, Schoen C, et al. Antimicrobial resistance profiles of coagulase-negative staphylococci in community-based healthy individuals in Germany. Front Public Health. 2021;9:684456. https:\/\/doi.org\/10.3389\/fpubh.2021.684456","DOI":"10.3389\/fpubh.2021.684456"},{"key":"ref35","doi-asserted-by":"publisher","unstructured":"Fowoyo PT, Ogunbanwo ST. Antimicrobial resistance in coagulase-negative staphylococci from Nigerian traditional fermented foods. Ann Clin Microbiol Antimicrob. 2017;16(1):4. https:\/\/doi.org\/10.1186\/s12941-017-0181-5","DOI":"10.1186\/s12941-017-0181-5"},{"key":"ref36","doi-asserted-by":"publisher","unstructured":"Asante J, Hetsa BA, Amoako DG, Abia ALK, Bester LA, Essack SY. Multidrug-resistant coagulase-negative staphylococci isolated from bloodstream in the uMgungundlovu district of KwaZulu-Natal province in South Africa: emerging pathogens. Antibiotics (Basel). 2021;10(2):198. https:\/\/doi.org\/10.3390\/antibiotics10020198","DOI":"10.3390\/antibiotics10020198"},{"key":"ref37","unstructured":"Sizar O, Leslie SW, Unakal CG. Gram-Positive Bacteria. [Updated 2023 May 30]. In: StatPearls [Internet]. StatPearls Publishing; 2023 Jan-. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK470553\/"},{"key":"ref38","doi-asserted-by":"publisher","unstructured":"Mehl A, \u00c5svold BO, K\u00fcmmel A, et al. Trends in antimicrobial resistance and empiric antibiotic therapy of bloodstream infections at a general hospital in Mid-Norway: a prospective observational study. BMC Infect Dis. 2017;17(1):116. https:\/\/doi.org\/10.1186\/s12879-017-2210-6","DOI":"10.1186\/s12879-017-2210-6"},{"key":"ref39","doi-asserted-by":"publisher","unstructured":"Sweeney TE, Liesenfeld O, May L. Diagnosis of bacterial sepsis: why are tests for bacteremia not sufficient? Expert Rev Mol Diagn. 2019;19(11):959-962. https:\/\/doi.org\/10.1080\/14737159.2019.1660644","DOI":"10.1080\/14737159.2019.1660644"},{"key":"ref40","doi-asserted-by":"publisher","unstructured":"Kadri SS, Lai YL, Warner S, et al. Inappropriate empirical antibiotic therapy for bloodstream infections based on discordant in-vitro susceptibilities: a retrospective cohort analysis of prevalence, predictors, and mortality risk in US hospitals. Lancet Infect Dis. 2021;21(2):241-251. https:\/\/doi.org\/10.1016\/S1473-3099(20)30477-1","DOI":"10.1016\/S1473-3099(20)30477-1"},{"key":"ref41","doi-asserted-by":"publisher","unstructured":"Aygun F, Aygun FD, Varol F, et al. Infections with carbapenem-resistant Gram-negative bacteria are a serious problem among critically Ill children: a single-centre retrospective study. Pathogens. 2019;8(2):69. https:\/\/doi.org\/10.3390\/pathogens8020069","DOI":"10.3390\/pathogens8020069"},{"key":"ref42","doi-asserted-by":"publisher","unstructured":"Neofytos D. Antimicrobial prophylaxis and preemptive approaches for the prevention of infections in the stem cell transplant recipient, with analogies to the hematologic malignancy patient. Infect Dis Clin North Am. 2019;33(2):361-380. https:\/\/doi.org\/10.1016\/ j.idc.2019.02.002","DOI":"10.1016\/j.idc.2019.02.002"}],"container-title":["Acta medica Lituanica"],"original-title":[],"link":[{"URL":"https:\/\/zurnalai.vu.lt\/\/AML\/article\/download\/33946\/33708","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/zurnalai.vu.lt\/\/AML\/article\/download\/33946\/33709","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/zurnalai.vu.lt\/\/AML\/article\/download\/33946\/33709","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/zurnalai.vu.lt\/\/AML\/article\/download\/33946\/33708","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T00:03:41Z","timestamp":1721693021000},"score":1,"resource":{"primary":{"URL":"https:\/\/zurnalai.vu.lt\/\/AML\/article\/view\/33946"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,24]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,2,27]]}},"URL":"https:\/\/doi.org\/10.15388\/amed.2024.31.1.17","relation":{},"ISSN":["2029-4174","1392-0138"],"issn-type":[{"type":"electronic","value":"2029-4174"},{"type":"print","value":"1392-0138"}],"subject":[],"published":{"date-parts":[[2024,5,24]]}}}