{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T18:30:54Z","timestamp":1754159454298,"version":"3.41.2"},"reference-count":15,"publisher":"Vilnius University Press","issue":"2","license":[{"start":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T00:00:00Z","timestamp":1735171200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AML"],"abstract":"<jats:p>Background:\u00a0The distal tibia is one of the rarest sites for the onset of malignant and locally aggressive bone tumors. When diagnosed, these lesions should undergo surgical resection with wide margins to eradicate the disease. In the era of limb-sparing surgery, several reconstructive approaches have been proposed and described in modern literature for reconstructing the distal tibia and the ankle. The 3D-printed custom-made prostheses represent an innovative and promising reconstructive option. Several authors highlighted that despite being expensive and prone to some complications such as talar collapse or loosening and soft tissue necrosis, the megaprostheses of the distal tibia could lead to good functional outcomes, also allowing a better range of motion compared to the most common arthrodesis.Materials and methods:\u00a0We report two cases who suffered from malignant bone tumors localized in the distal tibia and treated with wide resections and the implant of 3D printed custom-made megaprostheses to replace the distal tibia and the ankle.Results:\u00a0Both patients had excellent functional results (MSTS 30\/30) one year after surgery. No local recurrence occurred during the\u00a0patients\u2019\u00a0latest follow-up.Conclusions:\u00a0Our results support the effectiveness of custom-made implants in replacing the distal tibia and the ankle in orthopedic oncology.<\/jats:p>","DOI":"10.15388\/amed.2024.31.2.13","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T01:10:27Z","timestamp":1739236227000},"page":"372-381","source":"Crossref","is-referenced-by-count":0,"title":["Ankle and Distal Tibia Megaprostheses in Orthopedic Oncology: A Report of Two Cases and Review of the Literature"],"prefix":"10.15388","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2107-6357","authenticated-orcid":false,"given":"Edoardo","family":"Ipponi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9353-4320","authenticated-orcid":false,"given":"Martina","family":"Cordoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9276-4362","authenticated-orcid":false,"given":"Elena","family":"Bechini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizia","family":"Gentili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Cosseddu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"D'Arienzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8268-6987","authenticated-orcid":false,"given":"Lorenzo","family":"Andreani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6097","published-online":{"date-parts":[[2024,12,26]]},"reference":[{"doi-asserted-by":"publisher","unstructured":"Campanacci M. Bone and soft tissue tumors. 2nd ed. Springer-Verlag; 1999.","key":"ref0","DOI":"10.1007\/978-3-7091-3846-5"},{"doi-asserted-by":"publisher","unstructured":"Hwang JS, Mehta AD, Yoon RS, Beebe KS. From amputation to limb salvage reconstruction: evolution and role of the endoprosthesis in musculoskeletal oncology. J Orthop Traumatol. 2014;15(2):81-86. doi:10.1007\/s10195-013-0265-8","key":"ref1","DOI":"10.1007\/s10195-013-0265-8"},{"doi-asserted-by":"publisher","unstructured":"Zhao Z, Yan T, Guo W, Yang R, Tang X. Is double-strut fibula ankle arthrodesis a reliable reconstruction for bone defect after distal tibia tumor resection?-a finite element study based on promising clinical outcomes. J Orthop Surg Res. 2021;16(1):230. doi:10.1186\/s13018-021-02362-0","key":"ref2","DOI":"10.1186\/s13018-021-02362-0"},{"issue":"4","key":"ref3","doi-asserted-by":"publisher","first-page":"352","DOI":"10.23736\/S2784-8469.21.04057-8","article-title":"3D printing in orthopedic oncology surgery","volume":"72","author":"Andreani","year":"2021","unstructured":"Andreani L, Ipponi E, Neri E, Capanna R. 3D printing in orthopedic oncology surgery. Minerva Orthop. 2021;72(4):352-358.","journal-title":"Minerva Orthop"},{"doi-asserted-by":"publisher","unstructured":"Abudu A, Grimer RJ, Tillman RM, Carter SR. Endoprosthetic replacement of the distal tibia and ankle joint for aggressive bone tumours. Int Orthop. 1999;23(5):291-294. doi:10.1007\/s002640050374","key":"ref4","DOI":"10.1007\/s002640050374"},{"doi-asserted-by":"publisher","unstructured":"Lee SH, Kim HS, Park YB, Rhie TY, Lee HK. Prosthetic reconstruction for tumours of the distal tibia and fibula. J Bone Joint Surg Br. 1999;81(5):803-807. doi:10.1302\/0301-620x.81b5.9588","key":"ref5","DOI":"10.1302\/0301-620X.81B5.9588"},{"doi-asserted-by":"publisher","unstructured":"Natarajan MV, Annamalai K, Williams S, Selvaraj R, Rajagopal TS. Limb salvage in distal tibial osteosarcoma using a custom mega prosthesis. Int Orthop. 2000;24(5):282-284. doi:10.1007\/s002640000172","key":"ref6","DOI":"10.1007\/s002640000172"},{"doi-asserted-by":"publisher","unstructured":"Shekkeris AS, Hanna SA, Sewell MD, Spiegelberg BG, Aston WJ, Blunn GW, Cannon SR, Briggs TW. Endoprosthetic reconstruction of the distal tibia and ankle joint after resection of primary bone tumours. J Bone Joint Surg Br. 2009;91(10):1378-1382. doi:10.1302\/0301-620X.91B10.22643","key":"ref7","DOI":"10.1302\/0301-620X.91B10.22643"},{"doi-asserted-by":"publisher","unstructured":"Ajit Singh V, Nasirudin N, Bernatt M. Endoprosthetic reconstruction for giant cell tumors of the distal tibia: a short term review. Asia Pac J Clin Oncol. 2013;9(2):182-189. doi:10.1111\/j.1743-7563.2012.01553.x","key":"ref8","DOI":"10.1111\/j.1743-7563.2012.01553.x"},{"doi-asserted-by":"publisher","unstructured":"Yang P, Evans S, Khan Z, Abudu A, Jeys L, Grimer R. Reconstruction of the distal tibia following resection of aggressive bone tumours using a custom-made megaprosthesis. J Orthop. 2017;14(3):406-409. doi:10.1016\/j.jor.2017.06.003","key":"ref9","DOI":"10.1016\/j.jor.2017.06.003"},{"doi-asserted-by":"publisher","unstructured":"Kask G, Pakarinen TK, Parkkinen J, Kuokkanen H, Nieminen J, Laitinen MK. Tibia Adamantinoma Resection and Reconstruction with a Custom-Made Total Tibia Endoprosthesis: A Case Report with 8-Year Follow-Up. Case Rep Orthop. 2018;2018:3656913. doi:10.1155\/2018\/3656913","key":"ref10","DOI":"10.1155\/2018\/3656913"},{"doi-asserted-by":"publisher","unstructured":"Raciborska A, Bilska K, Malesza I, Rodriguez-Galindo C, Pachuta B. Distal Tibial Reconstruction in the Management of Primary Bone Tumors in Children and Adolescents. Foot Ankle Int. 2021;42(11):1447-1453. doi:10.1177\/10711007211012690","key":"ref11","DOI":"10.1177\/10711007211012690"},{"doi-asserted-by":"publisher","unstructured":"Savvidou OD, Gavriil P, Trikoupis I, Kaspiris A, Melissaridou DE, Papakonstantinou O, Korkolopoulou P, Papagelopoulos PJ. Three-dimensional Printed Endoprosthesis for Reconstruction of the Distal Tibia and Ankle Joint After Tumor Resection. Orthopedics. 2022;45(6):e348-e352. doi:10.3928\/01477447-20220706-07","key":"ref12","DOI":"10.3928\/01477447-20220706-07"},{"doi-asserted-by":"publisher","unstructured":"1Mugla W, Bauer HCF, Vogel J, Hosking KV, Campbell N, Hilton TL. Modular prosthetic reconstruction for primary bone tumours of the distal tibia in ten patients. 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