{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:38:03Z","timestamp":1785411483027,"version":"3.56.0"},"reference-count":19,"publisher":"Vilnius University Press","issue":"1","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AML"],"abstract":"<jats:p>Background: We present the case of a 15-year-old adolescent with swelling in the left vulva that was found to have a tumor measuring approximately 20x15 cm in her vulva. Ewing\u2019s sarcoma\/primitive neuroectodermal tumors (ES\/PNET) are rare and malignant.Materials and Methods: Preoperative magnetic resonance imaging and computed tomography performed to screen for metastasis were negative. The mass was surgically excised in total.Results: Immunohistochemistry showed the mass to be ES\/PNET. The patient underwent positron emission tomography-computed tomography which revealed metastasis to inguinal lymph nodes and bone. While under chemotherapy for stage-4 ES\/PNET, the patient was found to have lung metastasis. She died due to recurrent chemotherapy complications during treatment.Conclusions: This rare case highlights that significant of early diagnosis and multidisciplinary approach to treatment of ES\/PNET cases.<\/jats:p>","DOI":"10.15388\/amed.2026.33.1.19","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T05:35:08Z","timestamp":1784698508000},"page":"214-221","source":"Crossref","is-referenced-by-count":0,"title":["An Unusual Case of a Vulva Tumor in an Adolescent: A Case Report and Literature Review"],"prefix":"10.15388","volume":"33","author":[{"given":"Hayriye Nihan","family":"Karaman Ayyildiz","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/023wdy559","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Health Sciences \u0130stanbul \u00dcmranyie Training and Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zekeriya","family":"\u0130l\u00e7e","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02h67ht97","id-type":"ROR","asserted-by":"publisher"}],"name":"Sakarya Training and Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130lkay","family":"Tosun","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02h67ht97","id-type":"ROR","asserted-by":"publisher"}],"name":"Sakarya Training and Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Funda","family":"Tekkesin","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02h67ht97","id-type":"ROR","asserted-by":"publisher"}],"name":"Sakarya Training and Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6097","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Gostout BS, Lindor NM, DiMarco CS, Peethambaram PP, Clayton AC. Pelvic primitive neuroectodermal tumor associated with a cluster of small round cell tumors: case report and review of current literature. Gynecol Oncol. 2003;91(1):247-253. doi:10.1016\/s0090-8258(03)00416-5","DOI":"10.1016\/S0090-8258(03)00416-5"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Peres E, Mattoo TK, Poulik J, Warrier I. Primitive neuroectodermal tumor (PNET) of the uterus in a renal allograft patient: a case report. Pediatr Blood Cancer. 2005;44(3):283-285. doi:10.1002\/pbc.20237","DOI":"10.1002\/pbc.20237"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Xiao C, Zhao J, Guo P, et al. Clinical analysis of primary primitive neuroectodermal tumors in the female genital tract. Int J Gynecol Cancer. 2014;24(3):404-409. doi:10.1097\/IGC.0000000000000082","DOI":"10.1097\/IGC.0000000000000082"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Tunitsky-Bitton E, Uy-Kroh MJS, Michener C, Tarr ME. Primary Ewing sarcoma presenting as a vulvar mass in an adolescent: case report and review of literature. J Pediatr Adolesc Gynecol. 2015;28(6):e179-e183. doi:10.1016\/j.jpag.2015.04.004","DOI":"10.1016\/j.jpag.2015.04.004"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Yang J, Guo Q, Yang Y, Zhang J, Lang J, Shi H. Primary vulvar Ewing sarcoma\/primitive neuroectodermal tumor: a report of one case and review of the literature. J Pediatr Adolesc Gynecol. 2012;25(4):e93-e97. doi:10.1016\/j.jpag.2012.03.005","DOI":"10.1016\/j.jpag.2012.03.005"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Blattner JM, Gable P, Quigley MM, McHale MT. Primitive neuroectodermal tumor of the uterus. Gynecol Oncol. 2007;106(2):419-422. doi:10.1016\/j.ygyno.2007.04.008","DOI":"10.1016\/j.ygyno.2007.04.008"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Scherr GR, d'Ablaing G 3rd, Ouzounian JG. Peripheral primitive neuroectodermal tumor of the vulva. Gynecol Oncol. 1994;54(2):254-258. doi:10.1006\/gyno.1994.1204","DOI":"10.1006\/gyno.1994.1204"},{"key":"ref7","unstructured":"Lazure T, Alsamad IA, Meuric S, Orbach D, Fabre M. Sarcomes d'Ewing\/tumeurs neuroectodermiques primitives p\u00e9riph\u00e9riques de l'ut\u00e9rus et de la vulve chez l'enfant: deux localisations exceptionnelles [Primary uterine and vulvar Ewing's sarcoma\/peripheral neuroectodermal tumors in children: two unusual locations]. Ann Pathol. 2001;21(3):263-266."},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Fong YE, Lopez-Terrada D, Zhai QJ. Primary Ewing sarcoma\/peripheral primitive neuroectodermal tumor of the vulva. Hum Pathol. 2008;39(10):1535-1539. doi:10.1016\/j.humpath.2008.01.013","DOI":"10.1016\/j.humpath.2008.01.013"},{"key":"ref9","unstructured":"Halil S, Kucuk M, Arvas M, Aydin O, Calay ZZ. Peripheral primitive neuroectodermal tumor (PNET) of the vulva: a case report. Eur J Gynaecol Oncol. 2011;32(1):117-118."},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"Kelling K, Noack F, Altgassen C, Kujath P, Bohlmann MK, Hoellen F. Primary metastasized extraskeletal Ewing sarcoma of the vulva: report of a case and review of the literature. Arch Gynecol Obstet. 2012;285(3):785-789. doi:10.1007\/s00404-011-2011-x","DOI":"10.1007\/s00404-011-2011-x"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"Narayanan G, Rajan V, Puthusseri J, Kattoor J, Soman LV. Primitive neuroectodermal tumor of the vulva in an adolescent girl. World J Oncol. 2014;5(5-6):220-222. doi:10.14740\/wjon819w","DOI":"10.14740\/wjon819w"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"Rekhi B, Qureshi S, Basak R, et al. Primary vaginal Ewing's sarcoma or primitive neuroectodermal tumor in a 17-year-old woman: a case report. J Med Case Rep. 2010;4:88. doi:10.1186\/1752-1947-4-88","DOI":"10.1186\/1752-1947-4-88"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"Kakoti LM, Sharma JD, Kataki AC, Barmon D. Primary Ewing sarcoma of vulva: a case report and a review of literature. Indian J Gynecol Oncol. 2017;15:15. doi:10.1007\/s40944-017-0103-7","DOI":"10.1007\/s40944-017-0103-7"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"Xu QQ, Xing WW, Chen G, et al. Primitive neuroectodermal tumors of the abdominal wall and vulva in children: report of two cases and review of the literature. World J Clin Cases. 2019;7(21):3671-3682. doi:10.12998\/wjcc.v7.i21.3671","DOI":"10.12998\/wjcc.v7.i21.3671"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"McCluggage WG, Sumathi VP, Nucci MR, et al. Ewing family of tumors involving the vulva and vagina: report of a series of four cases. 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