{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T16:02:28Z","timestamp":1785600148240,"version":"3.56.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2013,2,26]],"date-time":"2013-02-26T00:00:00Z","timestamp":1361836800000},"content-version":"vor","delay-in-days":178,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Occupational Health"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:sec><jats:label\/><jats:p><jats:bold>Electrophysiological Studies of Shoemakers Exposed to Sub\u2010TLV Levels of n\u2010hexane: Masoud NEGHAB, <jats:italic>et al<\/jats:italic>. Department of Occupational Health, School of Health and Nutrition and Research Center for Health Sciences, Shiraz University of Medical Sciences, Iran\u2014<\/jats:bold><\/jats:p><\/jats:sec><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Exposure to n\u2010hexane, a neurotoxic solvent, has been associated with sensorimotor polyneuropathy, both in occupationally exposed workers and in glue\u2010sniffing addicts. The present study was carried out to ascertain whether exposure to sub\u2010TLV levels of n\u2010hexane was associated with electrophysiological abnormalities and to determine if these possible abnormalities have any correlations with parameters such as the biological exposure index (BEI) of this neurotoxic chemical, workers' TWA exposure to n\u2010hexane and\/or duration of employment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Twenty\u2010seven asymptomatic male workers from 6 shoemaking workshops were studied and compared with a group of 20 age\u2010 and sexmatched normal controls with no history of exposure to any neurotoxic agent. They underwent physical examinations as well as conventional needle electromyographic examinations and sensory and motor nerve conduction studies of upper and lower extremities. The TWA exposure to n\u2010hexane and urinary concentration of free 2,5\u2010hexanedione were also determined. Data were analyzed using version 16.0 of the SPSS\/PC statistical package.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The TWA exposure to n\u2010hexane was estimated to be 83.2 mg\/m<jats:sup>3<\/jats:sup>. Electrophysiological studies showed that the amplitudes of sensory nerve action potential (SAP) for median and sural nerves were significantly lower in exposed subjects than in unexposed normal controls. Additionally, a significant correlation was found between these decreases and the urinary concentration of free 2,5hexanedione.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The significant decrements in SAP amplitudes for the median and sural nerves may be considered as appropriate indicators for early detection of n\u2010hexane\u2010induced peripheral neuropathy in asymptomatic workers with current exposure to sub\u2010TLV levels of n\u2010hexane.<\/jats:p><\/jats:sec>","DOI":"10.1539\/joh.12-0029-fs","type":"journal-article","created":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T22:45:16Z","timestamp":1343861116000},"page":"376-382","source":"Crossref","is-referenced-by-count":27,"title":["Electrophysiological Studies of Shoemakers Exposed to Sub\u2010TLV Levels of n\u2010hexane"],"prefix":"10.1093","volume":"54","author":[{"given":"Masoud","family":"Neghab","sequence":"first","affiliation":[{"name":"Department of Occupational Health School of 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