{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T23:33:47Z","timestamp":1789774427455,"version":"4.0.1"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2014,2,6]],"date-time":"2014-02-06T00:00:00Z","timestamp":1391644800000},"content-version":"vor","delay-in-days":220,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Occupational Health"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:sec><jats:label\/><jats:p><jats:bold>Occupational Asthma in Female Factory Worker Resulting from Exposure to Savinase in Dishwashing Tablets\u2014A Case Study: Agnieszka LIPI\u0143SKA\u2010OJRZANOWSKA, <jats:italic>et al<\/jats:italic>. Department of Occupational Diseases, Nofer Institute of Occupational Medicine, Poland\u2014<\/jats:bold><\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Savinase is one of the endopeptidases widely used in washing detergents. Its ability to cause respiratory allergy has been known. Up to now, most cases of occupational asthma (OA) to savinase have been described among workers involved in the manufacture of laundry detergents. We present a case study of 51\u2010year\u2010old female worker of a dishwashing tablets factory, who had been packaging readymade tablets into foil wrappers for 4 years and developed respiratory symptoms, such as cough, dyspnoea and wheezing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A number of clinical procedures were performed, including the clinical examination, routine laboratory tests, evaluation of total and allergen\u2010specific serum IgE (asIgE) to enzymes, skin prick tests for common allergens, rest spirometry, inhalation methacholine challenge test and a single\u2010blind, placebo\u2010controlled specific inhalation challenge test (SICT) with dishwashing tablets.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Clinical findings and results of routine laboratory tests were within normal limits. Baseline nonspecific bronchial hyperreactivity was revealed. In patient's serum blood we found significantly elevated as IgE to savinase. Decline of FEV<jats:sub>1<\/jats:sub> and PEF in late phase of asthmatic reaction was observed during the specific challenge test. The patient reported chest tightness between 5\u221212 hours after exposure to dishwashing tablet ingredients. Cytological assessment of an induced sputum revealed increase in the percentage of eosinophils 24 hours after specific challenge in comparison to values noted before the SICT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Positive clinical response to the challenge confirmed in objective method tests validated the diagnosis of OA.<\/jats:p><\/jats:sec>","DOI":"10.1539\/joh.12-0169-cs","type":"journal-article","created":{"date-parts":[[2014,4,24]],"date-time":"2014-04-24T00:24:27Z","timestamp":1398299067000},"page":"318-321","source":"Crossref","is-referenced-by-count":7,"title":["Occupational Asthma in Female Factory Worker Resulting from Exposure to Savinase in Dishwashing Tablets\u2014A Case Study"],"prefix":"10.1093","volume":"55","author":[{"given":"Agnieszka","family":"Lipin\u00b4ska\u2010Ojrzanowska","sequence":"first","affiliation":[{"name":"Department of Occupational Diseases Nofer Institute of Occupational Medicine Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominika","family":"S>\u00b4wierczyn\u00b4ska\u2010Machura","sequence":"additional","affiliation":[{"name":"Centre of Occupational Allergy and Environmental Health, Nofer Institute of Occupational Medicine Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Tymoszuk","sequence":"additional","affiliation":[{"name":"Department of Occupational Diseases Nofer Institute of Occupational Medicine Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Nowakowska\u2010S\u00b4wirta","sequence":"additional","affiliation":[{"name":"Centre of Occupational Allergy and Environmental Health, Nofer Institute of Occupational Medicine Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolanta","family":"Walusiak\u2010Skorupa","sequence":"additional","affiliation":[{"name":"Department of Occupational Diseases Nofer Institute of Occupational Medicine Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,2,6]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(92)90662-4"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1263\/jbb.103.501"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(69)92165-5"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(70)90924-4"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(69)92166-7"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03264-5"},{"key":"e_1_2_1_8_1","first-page":"443","article-title":"Detergent enzymes: has the risk of occupational sensitization disappeared?","volume":"9","author":"Perdu D","year":"1992","journal-title":"Rev Mal Respir"},{"key":"e_1_2_1_9_1","unstructured":"Occupational Safety and Health Administration.Permissible exposure limits (PELs). 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