{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T15:46:24Z","timestamp":1785599184581,"version":"3.56.0"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"vor","delay-in-days":74,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Occupational Health"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:label\/><jats:p><jats:bold>Risk of bile duct cancer among printing workers exposed to 1,2\u2010dichloropropane and\/or dichloromethane: Tomotaka S<jats:sc>obue<\/jats:sc>, <jats:italic>et al<\/jats:italic>. Department of Environmental Medicine and Population Sciences, Graduate School of Medicine, Osaka University<\/jats:bold><\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We conducted a retrospective cohort study to examine the risk of bile duct cancer among current and former workers in the offset color proof printing department at a printing company in Osaka, Japan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Standardized incidence ratios (SIRs) between January 1, 1985, and December 31, 2012, were estimated for the cumulative years of exposure to two chemicals, dichloromethane (DCM) and 1,2\u2010dichloropropane (1,2\u2010DCP), using the national incidence level as a reference. In addition, we examined risk patterns by the calendar year in which observation started.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 106 workers with a total of 1,452.4 person\u2010years of exposure, 17 bile duct cancer cases were observed, resulting in an estimated overall SIR of 1,132.5 (95% confidence interval (CI): 659.7\u22121,813.2). The SIR was 1,319.9 (95% CI: 658.9\u22122,361.7) for those who were exposed to both DCM and 1,2\u2010DCP, and it was 1,002.8 (95% CI: 368.0\u22122,182.8) for those exposed to 1,2\u2010DCP only. SIRs tended to increase according to years of exposure to 1,2\u2010DCP but not DCM when a 5year lag time was assumed. The SIRs were higher for the cohorts in which observation started in 1993\u22122000, particularly in cohorts in which it started in 1996\u22121999, compared with those in which it started before or after 1993\u22122000.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We observed an extraordinarily high risk of bile duct cancer among the offset color proof printing workers. Elevated risk may be related to cumulative exposure to 1,2\u2010DCP, but there remains some possibility that a portion of the risk is due to other unidentified substances.<\/jats:p><\/jats:sec>","DOI":"10.1539\/joh.14-0116-oa","type":"journal-article","created":{"date-parts":[[2015,2,6]],"date-time":"2015-02-06T22:04:55Z","timestamp":1423260295000},"page":"230-236","source":"Crossref","is-referenced-by-count":19,"title":["Risk of bile duct cancer among printing workers exposed to 1,2\u2010dichloropropane and\/or dichloromethane"],"prefix":"10.1093","volume":"57","author":[{"given":"Tomotaka","family":"Sobue","sequence":"first","affiliation":[{"name":"Department of Environmental Medicine and Population Sciences Graduate School of Medicine, Osaka University Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Utada","sequence":"additional","affiliation":[{"name":"Department of Mathematical Health Science Graduate School of Medicine, Osaka University Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Makiuchi","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine and Population Sciences Graduate School of Medicine, Osaka University Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Ohno","sequence":"additional","affiliation":[{"name":"Department of Mathematical Health Science Graduate School of Medicine, Osaka University Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichiro","family":"Uehara","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Environmental Health Graduate School of Medicine, Osaka City University Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoshige","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Environmental Health Graduate School of Medicine, Osaka City University Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoko Kogawa","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Environmental Health Graduate School of Medicine, Osaka City University Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ginji","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Environmental Health Graduate School of Medicine, Osaka City University Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,7,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/oemed-2012-101246"},{"key":"e_1_2_1_3_1","unstructured":"Occupational Biliary Tract Cancer Cases in Japan:Report of the \u201cExpert Panel on Biliary Tract Cancer at printing plants\u201d and actions to be taken by the Ministry of Health Labour and Welfare. [Online].2014[cited 2014 Dec 22]; Available from: URL:http:\/\/www.mhlw.go.jp\/english\/policy\/employ\u2010labour\/labour\u2010standards\/dl\/Occupational_02.pdf"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20130122"},{"key":"e_1_2_1_5_1","first-page":"31","volume-title":"Epidemiologic analysis with a programmable calculator","author":"Rothman KJ","year":"1979"},{"key":"e_1_2_1_6_1","unstructured":"SullivanKM DeanAG SoeMM.OpenEpi: Open Source Epidemiologic Statistics for Public Health Version 3.03. 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