{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T20:46:34Z","timestamp":1759178794605},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2015,2,14]],"date-time":"2015-02-14T00:00:00Z","timestamp":1423872000000},"content-version":"vor","delay-in-days":44,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Occupational Health"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec><jats:label \/><jats:p><jats:bold>Severe acute hepatitis in a printing company worker: A case study: Shoji KUBO, <jats:italic>et al<\/jats:italic>. Department of Hepato\u2010Biliary\u2010Pancreatic Surgery, Osaka City University Graduate School of Medicine\u2014<\/jats:bold><\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>It has been reported that chlorinated organic solvent is a cause of hepatitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>we investigate clinical and pathological findings of a patient with severe acute hepatitis who was exposed to chlorinated organic solvents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A 34\u2010year\u2010old man who was exposed to chlorinated organic solvents including dichloromethane, 1,2\u2010dichloropropane, and trichloroethylene, presented with general fatigue, vomiting, and diarrhea. At admission, his laboratory test results showed extremely elevated aspartate aminotransferase (4,872 IU\/l), alanine aminotransferase (3,000 IU\/l), and lactate dehydrogenase (11,600 IU\/l) levels and a prothrombin level below normal (41%). No encephalopathy was noted. These findings were indicative of severe acute hepatitis. Viral hepatitis, autoimmune hepatitis, alcoholic disease, bile duct disease, and viral infection were excluded as causes of hepatitis by clinical, laboratory, and imaging findings. After diagnosis, the patient was administered fresh frozen plasma and glucagon\u2010insulin therapy. Liver function recovered within a few weeks, and a liver biopsy performed 25 days after admission showed the recovery phase after acute liver damage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These clinical and pathological findings indicate that exposure to chlorinated organic solvents may have induced severe acute hepatitis in this patient.<\/jats:p><\/jats:sec>","DOI":"10.1539\/joh.14-0122-cs","type":"journal-article","created":{"date-parts":[[2014,11,19]],"date-time":"2014-11-19T01:54:15Z","timestamp":1416362055000},"page":"87-90","source":"Crossref","is-referenced-by-count":9,"title":["Severe acute hepatitis in a printing company worker: A case study"],"prefix":"10.1093","volume":"57","author":[{"given":"Shoji","family":"Kubo","sequence":"first","affiliation":[{"name":"Department of Hepato\u2010Biliary\u2010Pancreatic Surgery Osaka City University Graduate School of Medicine Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Matsuzaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Kansai Medical University Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihito","family":"Seki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Kansai Medical University Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Ohsawa","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Osaka City University Graduate School of Medicine Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Kumagai","sequence":"additional","affiliation":[{"name":"Department of Management of Occupational Safety and Health University of Occupational and Environmental Health Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ginji","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Environmental Health Osaka City University Graduate School of Medicine Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2015,2,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043764-199410000-00010"},{"key":"e_1_2_1_3_1","unstructured":"International Labour Organization.International Chemical Safety Cards (ICSC).http:\/\/www.ilo.org\/dyn\/icsc\/showcard.home"},{"key":"e_1_2_1_4_1","first-page":"770","article-title":"Toxicity in man due to stain removers containing 1,2\u2010dichloropropane","volume":"42","author":"Pozzi C","year":"1985","journal-title":"Br J Indust Med"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0379-0738(88)90015-1"},{"key":"e_1_2_1_6_1","first-page":"185","article-title":"A case of severe hepatic microcirculatory failure with jaundice and fibrosis around the sinusoid caused by long\u2010term exposure of methylenechloride","volume":"88","author":"Sakai T","year":"1991","journal-title":"Jpn J Gastroenterol"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1081\/CLT-100102442"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.35371\/kjoem.2003.15.1.111"},{"key":"e_1_2_1_9_1","first-page":"355","article-title":"Hepatitis caused by occupational exposure to trichloroethylene","volume":"67","author":"Anagnostopoulos G","year":"2004","journal-title":"Acta Gastroenterol Belg"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-007-2146-5"},{"key":"e_1_2_1_11_1","unstructured":"National Institute of Occupational Safety and Health Japan.Industrial accident in a printing company in Osaka [in Japanese]. 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