{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T13:00:21Z","timestamp":1759496421311},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"vor","delay-in-days":74,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Occupational Health"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:label \/><jats:p><jats:bold>Chemical exposure levels in printing workers with cholangiocarcinoma (second report): Kenichi Y<jats:sc>amada<\/jats:sc>, <jats:italic>et al<\/jats:italic>. Occupational Health Research and Development Center, Japan Industrial Safety and Health Association<\/jats:bold><\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>In several Japanese printing plants, printing workers have suffered from cholangiocarcinoma. 1,2\u2010dichloropropane (1,2\u2010DCP) is considered to be a causative agent, and whether or not other chemicals also contribute to the development of this disease has not been conclusively determined. This study aimed to identify the chemicals used by seven printing workers who developed cholangiocarcinoma, as well as to estimate the levels of chemical exposure among them.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Information was obtained from the Ministry of Health, Labour and Welfare, Japan, to identify chemicals used by printing workers who developed cholangiocarcinoma and to estimate chemical exposure concentrations. Working environment concentrations of the chemicals in the printing rooms were estimated using a well\u2010mixed model, and exposure concentrations during the ink removal operation were estimated using a near\u2010field and far\u2010field model. Shift time\u2010weighted averages of exposure concentrations were also calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four of the seven printing workers were exposed to both 1,2\u2010DCP and dichloromethane (DCM). The estimated maximum exposure concentrations for each of the four workers were 230 to 420 ppm for 1,2\u2010DCP and 58 to 720 ppm for DCM, and the estimated shift average exposure concentrations were 0 to 210 ppm for 1,2\u2010DCP and 15 to 270 ppm for DCM. The remaining three workers were exposed to DCM but not 1,2\u2010DCP. The estimated maximum exposure concentrations of DCM for each of the three workers were 600 to 1,300 ppm, and the estimated shift average exposure concentrations were 84 to 440 ppm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings suggest that DCM may contribute to the development of cholangiocarcinoma in humans.<\/jats:p><\/jats:sec>","DOI":"10.1539\/joh.14-0239-oa","type":"journal-article","created":{"date-parts":[[2015,2,13]],"date-time":"2015-02-13T22:02:36Z","timestamp":1423864956000},"page":"245-252","source":"Crossref","is-referenced-by-count":12,"title":["Chemical exposure levels in printing workers with cholangiocarcinoma (second report)"],"prefix":"10.1093","volume":"57","author":[{"given":"Kenichi","family":"Yamada","sequence":"first","affiliation":[{"name":"Occupational Health Research and Development Center, Japan Industrial Safety and Health Association Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Kumagai","sequence":"additional","affiliation":[{"name":"Department of Occupational Safety and Health Management University of Occupational and Environmental Health Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ginji","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Environmental Health Osaka City University Graduate School of Medicine Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2015,7,14]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"297","volume-title":"Proceedings of the 85th Annual Meeting of the Japan Society for Occupational Health","author":"Kumagai S","year":"2012"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhbp.86"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/oemed-2012-101246"},{"key":"e_1_2_1_5_1","unstructured":"The worker compensation panel of the Ministry of Health Labour and Welfare.Report of the worker compensation panel on cholangiocarginoma among printing workers.2013(in Japanese)."},{"key":"e_1_2_1_6_1","unstructured":"Japan Industrial Safety and Health Association.The number of claims filed and results on biliary tract cancer cases at printing plants. [Online].2014[cited 2014 Sep 1]; Available from URL:http:\/\/www.jisha.or.jp\/english\/pdf\/Number_of_claims.pdf"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1539\/joh.14-0073-OA"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/15428119691014756"},{"key":"e_1_2_1_9_1","first-page":"62","volume-title":"Handbook for risk assessment and risk management of chemical substances and other environment factors","author":"Yamada K","year":"2007"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.15.S150"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20130122"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.5271\/sjweh.1788"}],"container-title":["Journal of Occupational Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1539%2Fjoh.14-0239-OA","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1539\/joh.14-0239-OA","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1539\/joh.14-0239-OA","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T18:08:25Z","timestamp":1705082905000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/joh\/article\/57\/3\/245-252\/7250699"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1539\/joh.14-0239-OA"],"URL":"https:\/\/doi.org\/10.1539\/joh.14-0239-oa","archive":["Portico"],"relation":{},"ISSN":["1341-9145","1348-9585"],"issn-type":[{"value":"1341-9145","type":"print"},{"value":"1348-9585","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5]]}}}