{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T11:00:08Z","timestamp":1769425208498,"version":"3.49.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2016,2,29]],"date-time":"2016-02-29T00:00:00Z","timestamp":1456704000000},"content-version":"vor","delay-in-days":59,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Occupational Health"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec><jats:label\/><jats:p><jats:bold>Study of risk factors for atopic sensitization, asthma, and bronchial hyperresponsiveness in animal laboratory workers: Christian Silva S<jats:sc>imoneti<\/jats:sc>, <jats:italic>et al<\/jats:italic>. Department of Medicine, Medical School of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Brazil<\/jats:bold><\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this estudy was to investigate the influence of allergen exposure levels and other risk factors for allergic sensitization, asthma, and bronchial hyperresponsiveness (BHR) in workers exposed to laboratory animals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a crosssectional study performed at two universities, 123 workplaces with 737 subjects. Dust samples were collected from laboratories and animal facilities housing rats, mice, guinea pigs, rabbits, or hamsters and analyzed by enzyme\u2010linked immunosorbent assay (ELISA) to measure allergen concentrations. We also sampled workplaces without animals. Asthma was defined by both symptoms and BHR to mannitol. The concentrations of allergens were tested for association with a skin prick test, respiratory symptoms, spirometry data, and BHR. This multivariate analysis was performed by using Poisson regression to estimate the relative risk (RR) for the exposed group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our sample comprised students and workers, with 336 subjects in the nonexposed group and 401 subjects in the exposed group. Sixty\u2010nine subjects (17%) had positive results in the skin prick test for animal allergens in the exposed group; in the nonexposed group, 10 subjects had positive results (3%) (<jats:italic>p<\/jats:italic>&lt;0.001). Exposure to laboratory animals over 2.8 years was associated with atopic sensitization (RR=1.85; 95% confidence interval: 1.09\u22123.15; <jats:italic>p<\/jats:italic>=0.02). Allergen concentration was not associated with sensitization, asthma, or BHR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Exposure to laboratory animals was associated with atopic sensitization. However, we did not find a cutoff allergen concentration that increased the risk for sensitization. Duration of exposure seems to be more relevant to sensitization than concentration of allergens in dust.<\/jats:p><\/jats:sec>","DOI":"10.1539\/joh.15-0045-oa","type":"journal-article","created":{"date-parts":[[2015,10,19]],"date-time":"2015-10-19T22:09:39Z","timestamp":1445292579000},"page":"7-15","source":"Crossref","is-referenced-by-count":13,"title":["Study of risk factors for atopic sensitization, asthma, and bronchial hyperresponsiveness in animal laboratory workers"],"prefix":"10.1093","volume":"58","author":[{"given":"Christian Silva","family":"Simoneti","sequence":"first","affiliation":[{"name":"Department of Medicine Medical School of Ribeir\u00e3o Preto, University of S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda Souza","family":"Freitas","sequence":"additional","affiliation":[{"name":"Department of Social Medicine Medical School of Ribeir\u00e3o Preto, University of S\u00e3o Paulo 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