{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T15:46:23Z","timestamp":1785599183682,"version":"3.56.0"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2015,12,25]],"date-time":"2015-12-25T00:00:00Z","timestamp":1451001600000},"content-version":"vor","delay-in-days":54,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Occupational Health"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec><jats:label\/><jats:p><jats:bold>Chemical exposure levels in printing and coating workers with cholangiocarcinoma (third report): Kenichi Y<jats:sc>amada<\/jats:sc>, <jats:italic>et al<\/jats:italic>. Occupational Health Research and Development Center, Japan Industrial Safety and Health Association<\/jats:bold><\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to identify the chemicals used by five printing workers and one coating worker who developed cholangiocarcinoma and estimate the workers\u2019 levels of chemical exposure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We obtained information on chemicals from the Ministry of Health, Labour and Welfare, Japan, and estimated working environment concentrations of the chemicals in printing and coating rooms and exposure concentrations during the ink and dirt removal processes. We also calculated shift time\u2010weighted averages of exposure concentrations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All five printing workers were exposed to both 1,2\u2010dichloropropane (1,2\u2010DCP) and dichloromethane (DCM). The estimated maximum exposure concentrations for each of the five workers were 190 to 560 ppm for 1,2\u2010DCP and 300 to 980 ppm for DCM, and the estimated shift average exposure concentrations were 0 to 230 ppm for 1,2\u2010DCP and 20 to 470 ppm for DCM. The coating worker was exposed to 1,2\u2010DCP, but not DCM. He did not use ink, and thus was subjected to different conditions than the printing workers. The estimated maximum exposure concentration of 1,2\u2010DCP was 150 ppm, and the estimated shift time\u2010weighted average exposure concentration was 5 to 19 ppm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings support the notion that 1,2\u2010DCP contributes to the development of cholangiocarcinoma in humans and the notion that DCM may also be a contributing factor. The finding that the coating worker was exposed to 1,2\u2010DCP at a lower exposure concentration is important for determining the occupational exposure limit. Furthermore, the subject did not use ink, which suggests that ink did not contribute to the development of cholangiocarcinoma.<\/jats:p><\/jats:sec>","DOI":"10.1539\/joh.15-0170-oa","type":"journal-article","created":{"date-parts":[[2015,10,6]],"date-time":"2015-10-06T22:03:26Z","timestamp":1444169006000},"page":"565-571","source":"Crossref","is-referenced-by-count":13,"title":["Chemical exposure levels in printing and coating workers with cholangiocarcinoma (third report)"],"prefix":"10.1093","volume":"57","author":[{"given":"Kenichi","family":"Yamada","sequence":"first","affiliation":[{"name":"Occupational Health Research and Development Center Japan Industrial Safety and Health Association Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Kumagai","sequence":"additional","affiliation":[{"name":"Department of Occupational Safety and Health Management University of Occupational and Environmental Health Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoji","family":"Kubo","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Biliary\u2010Pancreatic Surgery Osaka City University Graduate, School of Medicine Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ginji","family":"Endo","sequence":"additional","affiliation":[{"name":"The Institute for Science of Labour Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,12,25]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"297","volume-title":"Proceedings of the 85th Annual Meeting of the Japan Society for Occupational Health; 30 May to 2 June","author":"Kumagai S","year":"2012"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/oemed-2012-101246"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhbp.86"},{"key":"e_1_2_1_5_1","unstructured":"Japan Industrial Safety and Health Association.The number of claims filed and results on biliary tract cancer cases at printing plants. [Online].2015[cited 2015 Apr]: Available from: URL:http:\/\/www.jisha.or.jp\/english\/pdf\/The_Number_of_Claims_31_Jan_2015_Tokyo.pdf"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1539\/joh.14-0073-OA"},{"key":"e_1_2_1_7_1","article-title":"Chemical exposure levels in printing workers with cholangiocarcinoma","author":"Yamada K","journal-title":"J Occup Health"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/15428119691014756"},{"key":"e_1_2_1_9_1","first-page":"62","volume-title":"Handbook for risk assessment and risk management of chemical substances and other environment factors","author":"Yamada K","year":"2007"}],"container-title":["Journal of Occupational Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1539%2Fjoh.15-0170-OA","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1539\/joh.15-0170-OA","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1539\/joh.15-0170-OA","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T18:08:58Z","timestamp":1705082938000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/joh\/article\/57\/6\/565-571\/7250694"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":8,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1539\/joh.15-0170-OA"],"URL":"https:\/\/doi.org\/10.1539\/joh.15-0170-oa","archive":["Portico"],"relation":{},"ISSN":["1341-9145","1348-9585"],"issn-type":[{"value":"1341-9145","type":"print"},{"value":"1348-9585","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11]]}}}