{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T16:41:24Z","timestamp":1761324084613},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:00:00Z","timestamp":1696896000000},"content-version":"vor","delay-in-days":2414,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,3,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>We conducted a 6-year cohort study to evaluate the relationship between carbon disulfide (CS2) exposure and reductions in the motor and sensory nerve conduction velocity (MCV and SCV) of the median nerve.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Study subjects at baseline included 432 exposed workers and 402 unexposed workers. Among the exposed workers, 145 workers terminated CS2 exposure during the followup period (ex-exposed workers). MCV and SCV were measured at baseline and followed up. CS2 personal exposure concentration was measured two times a year during a 6-year follow-up period and mean (range) CS2 exposure concentrations (ppm) were 5.96 (0.8-16.0) and 3.93 (0.6-9.9) in the exposed and ex-exposed workers, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Reductions in MCV during the follow-up period did not differ among the exposed, ex-exposed, and unexposed workers. Reduction in SCV (m\/s) of the exposed workers (\u22124.47\u00b13.94) was significantly larger than that of the unexposed (\u22123.38\u00b13.97) and ex-exposed workers (\u22123.26\u00b13.79). For SCV reduction, a partial multiple regression coefficient of (exexposed workers)\/(unexposed workers) was significantly positive (+0.915, p &amp;lt; 0.01) after adjustment for confounding variables.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This cohort study showed that 6-year CS2 exposure around a mean level of 6 ppm did not affect MCV reduction but induced significant SCV reduction beyond the influence of aging. The effect of CS2 on SCV around a mean exposure level of 4 ppm may be reversible, since it disappeared in the ex-exposed workers after CS2 exposure cessation for a mean period of 4.1 years.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1539\/joh.16-0255-oa","type":"journal-article","created":{"date-parts":[[2017,1,20]],"date-time":"2017-01-20T22:11:10Z","timestamp":1484950270000},"page":"187-193","source":"Crossref","is-referenced-by-count":2,"title":["Changes of median nerve conduction velocity in rayon manufacturing workers: A 6-year cohort study"],"prefix":"10.1093","volume":"59","author":[{"given":"Noriyuki","family":"Yoshioka","sequence":"first","affiliation":[{"name":"Department of Preventive Medicine and Public Health, Keio University School of Medicine , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Takebayashi","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Public Health, Keio University School of Medicine , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Nishiwaki","sequence":"additional","affiliation":[{"name":"Department of Environmental and Occupational Health, Toho University , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuo","family":"Nomiyama","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Public Health, Shinshu University , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoko","family":"Iwasawa","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Public Health, Keio University School of Medicine , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruhiko","family":"Sakurai","sequence":"additional","affiliation":[{"name":"Occupational Health Research and Development Center, Japan Industrial Safety and Health Association , 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