{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:45:50Z","timestamp":1773290750027,"version":"3.50.1"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2003,10,23]],"date-time":"2003-10-23T00:00:00Z","timestamp":1066867200000},"content-version":"vor","delay-in-days":52,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Occupational Health"],"published-print":{"date-parts":[[2003,9]]},"abstract":"<jats:p><jats:bold>Oxidative Stress, <jats:italic>hogg1<\/jats:italic> Expression and NF\u2010\u03baB Activity in Cells Exposed to Low Level Chromium: Yong\u2010Dae Kim, <jats:italic>et al.<\/jats:italic> Department of Preventive Medicine, College of Medicine, Chungbuk National University, South Korea<\/jats:bold>\u2014 Chromium compounds are carcinogenic to the human lung, although the detailed biochemical mechanism is still unclear. To understand the carcinogenic mechanism in cells exposed to low level hexavalent chromium, we measured the generation of reactive oxygen species (ROS) and 8\u2010hydroxydeoxyguanosine (8\u2010OH\u2010dG), the transcription of <jats:italic>hogg1<\/jats:italic>, which encodes an 8\u2010OH\u2010dG repair protein, and NF\u2010\u03baB activation levels in the A549 human lung epithelial cell line after exposure to Cr (VI) at concentrations of 12.5 to 800 \u00b5M. In A549 cells, ROS levels and DNA binding by NF\u2010\u03baB increased in proportion to the concentration of Cr (VI). These increases were diminished by pretreatment with catalase, superoxide dismutase, or D\u2010mannitol, but the levels of 8\u2010OH\u2010dG and expression of <jats:italic>hogg1<\/jats:italic> did not change significantly with Cr (VI) exposure. These results suggest that the induction of ROS and the activation of NF\u2010\u03baB are important in the carcinogenic mechanism of Cr (VI), but it is unlikely that Cr (VI) concentrations below 800 \u00b5M increase 8\u2010OH\u2010dG levels or the expression of <jats:italic>hogg1<\/jats:italic>.<\/jats:p>","DOI":"10.1539\/joh.45.271","type":"journal-article","created":{"date-parts":[[2004,3,23]],"date-time":"2004-03-23T06:02:36Z","timestamp":1080021756000},"page":"271-277","source":"Crossref","is-referenced-by-count":13,"title":["Oxidative Stress, <i>hogg1<\/i> Expression and NF\u2010\u03baB Activity in Cells Exposed to Low Level Chromium"],"prefix":"10.1093","volume":"45","author":[{"given":"Yong\u2010Dae","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Preventive Medicine College of Medicine, Chungbuk National University South 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