{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:02:48Z","timestamp":1790827368571,"version":"4.1.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2003,5,21]],"date-time":"2003-05-21T00:00:00Z","timestamp":1053475200000},"content-version":"vor","delay-in-days":140,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Occupational Health"],"published-print":{"date-parts":[[2003,1]]},"abstract":"<jats:p><jats:bold>Generalized Skin Reactions in Relation to Trichloroethylene Exposure: A Review from the Viewpoint of Drug\u2010metabolizing Enzymes: Tamie Nakajima, <jats:italic>et al.<\/jats:italic> Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine<\/jats:bold>\u2014The literature was reviewed to study cases of intoxication with systemic dermatitis associated with exposure to trichloroethylene. The average age of patients in the reports reviewed to date was twenty\u2010nine; these diseases were found in relatively young persons and no difference was found according to gender. Many cases occurred within one month after the onset of exposure to trichloroethylene, and were accompanied by hepatitis, jaundice, hepatomegaly or hepatosplenomegaly. Most of the patients had no history of drug abuse or herpes infection. The level of exposure to trichloroethylene was not recorded in many cases, but ranged from less than 9 ppm to 800 ppm. In the severest cases, the lesions involved mucous membranes such as the conjunctiva and oral cavity, and the patients were diagnosed with Stevens\u2010Johnson syndrome, but the etiology of the disease after trichloroethylene exposure remains unclear. Since several drugs have also been shown to cause systemic dermatitis with hepatitis, susceptibility factors are discussed. Many patients were found to have the slow acetylator genotype of Nacetyltransferase (NAT) 2, suggesting that the NAT2 genotype is a susceptibility factor. This hypothesis may also be applicable to trichloroethylene because NAT is involved in the glutathione\u2010mediated metabolism.<\/jats:p>","DOI":"10.1539\/joh.45.8","type":"journal-article","created":{"date-parts":[[2004,3,23]],"date-time":"2004-03-23T06:02:36Z","timestamp":1080021756000},"page":"8-14","source":"Crossref","is-referenced-by-count":39,"title":["Generalized Skin Reactions in Relation to Trichloroethylene Exposure: A Review from the Viewpoint of Drug\u2010Metabolizing Enzymes"],"prefix":"10.1093","volume":"45","author":[{"given":"Tamie","family":"Nakajima","sequence":"first","affiliation":[{"name":"Department of Occupational and Environmental Health Nagoya University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Yamanoshita","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health Nagoya University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michihiro","family":"Kamijima","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health Nagoya University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiko","family":"Kishi","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences Hokkaido University Graduate School of Medicine Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaku","family":"Ichihara","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health Nagoya University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2003,5,21]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"75","volume-title":"Dry Cleaning, Some Chlorinated Solvents and other Industrial Chemicals","author":"International Agency for Research on Cancer","year":"1995"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.2486\/indhealth.35.301"},{"key":"e_1_2_1_4_1","first-page":"33","article-title":"Stevens\u2010Johnson Syndrome accompanied by acute hepatitis in workers exposed to trichloroethylene or tetrachloroethylene","volume":"44","author":"Hisanaga N","year":"2002","journal-title":"San Ei Shi"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1984.tb00145.x"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.66.779.730"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1974.01630120036007"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1988.tb02867.x"},{"key":"e_1_2_1_9_1","first-page":"461","article-title":"Hepatitis, rash and eosinophilia following trichloroethylene exposure: a case report and speculation on mechanistic similarity to halothane induced hepatitis","volume":"34","author":"Bond GR","year":"1996","journal-title":"Clin Toxicol"},{"key":"e_1_2_1_10_1","first-page":"144","article-title":"Fever, skin rash, jaundice and lymphadenopathy after trichloroethylene exposure: a case report","volume":"80","author":"Chittasobhaktra T","year":"1997","journal-title":"J Med Assoc Thai"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1982.tb04237.x"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(68)90110-1"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1978.01640140059014"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6096.1189"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)92919-7"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1963.tb23529.x"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1977.01640050146034"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1966.01600290019004"},{"key":"e_1_2_1_19_1","first-page":"30","article-title":"New problems caused by occupational trichloroethylene exposure","volume":"15","author":"Huang HL","year":"2002","journal-title":"Int J Immunnpathol Pharmacol"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1539\/joh.39.83"},{"key":"e_1_2_1_21_1","first-page":"779","article-title":"Species\u2010 and sex\u2010related differences in metabolism of trichloroethylene to yield chloral and trichloroethanol in mouse, rat, and human liver microsomes","volume":"26","author":"Elfarra AA","year":"1998","journal-title":"Drug Met Dis"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1996.8040"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(88)90264-5"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(91)90084-R"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.00108s2177"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(98)00132-2"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(95)02009-8"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.3109\/03602539409029783"},{"key":"e_1_2_1_29_1","first-page":"5230","article-title":"Role of aromatic amine acetyltransferasea, NAT1 and NAT2, in carcinogen\u2010DNA adducts formation in the human urinary bladder","volume":"55","author":"Badawi AF","year":"1995","journal-title":"Cancer Res"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1089\/dna.1990.9.193"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-199508000-00011"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.1995.tb00211.x"}],"container-title":["Journal of Occupational Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1539%2Fjoh.45.8","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1539\/joh.45.8","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1539\/joh.45.8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T18:14:50Z","timestamp":1705083290000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/joh\/article\/45\/1\/8-14\/7270960"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,1]]}},"alternative-id":["10.1539\/joh.45.8"],"URL":"https:\/\/doi.org\/10.1539\/joh.45.8","archive":["Portico"],"relation":{},"ISSN":["1341-9145","1348-9585"],"issn-type":[{"value":"1341-9145","type":"print"},{"value":"1348-9585","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,1]]}}}