{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T12:48:15Z","timestamp":1788439695859,"version":"build-2803163510"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2003,5,30]],"date-time":"2003-05-30T00:00:00Z","timestamp":1054252800000},"content-version":"vor","delay-in-days":90,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Occupational Health"],"published-print":{"date-parts":[[2003,3]]},"abstract":"<jats:p><jats:bold>Neuropsychiatric Effects in Workers with Occupational Exposure to Carbon Disulfide: Srmena Krstev, <jats:italic>et al.<\/jats:italic> Clinical Center of Serbia, Institute of Occupational and Radiological Health, Yugoslavia<\/jats:bold>\u2014In a cross\u2010sectional study, prevalence of dysfunctions of the central nervous system was assessed in 134 male workers exposed to different levels of carbon disulfide (CS<jats:sub>2<\/jats:sub>) in a rayon viscose plant and compared to 38 non\u2010exposed workers. In three groups of workers from the same plant with different levels of CS<jats:sub>2<\/jats:sub> (heavy, intermediate, none) estimated by personal samplers, disorders in the central nervous system were examined by means of psychiatric examination and questionnaire 16 (Q16). Unconditional logistic regression was calculated adjusted for age, alcohol consumption and education. Psychoorganic syndrome was diagnosed significantly more often in workers with heavy CS<jats:sub>2<\/jats:sub> exposure, with adjusted OR of 17.9 (95% CI 2.18\u2013146.73), and insignificantly in workers with intermediate exposure. Prevalence of workers with more than 6 positive answers on the Q16 was higher in the heavily exposed workers (OR=4.76; 95% CI 1.80\u201312.60). A similar result was found for almost all the questions in the Q16, and the most pronounced psychological symptom was of less interest in sex (adjusted OR=8.14; 95% CI 2.19\u2013 30.22). High correlation was found between symptoms recorded on neuropsychiatric examination and on Q16. Both neuropsychiatric exams and Q16 indicated disturbances in the central nervous system due to the long\u2010term heavy exposure to CS<jats:sub>2<\/jats:sub>. Disorders of the central nervous system were found more often in workers with heavy exposure to CS<jats:sub>2<\/jats:sub>. Questionnaire Q16 is a valuable means for selecting workers for further neuropsychiatric testing.<\/jats:p>","DOI":"10.1539\/joh.45.81","type":"journal-article","created":{"date-parts":[[2004,3,23]],"date-time":"2004-03-23T06:02:36Z","timestamp":1080021756000},"page":"81-87","source":"Crossref","is-referenced-by-count":15,"title":["Neuropsychiatric Effects in Workers with Occupational Exposure to Carbon Disulfide"],"prefix":"10.1093","volume":"45","author":[{"given":"Srmena","family":"Krstev","sequence":"first","affiliation":[{"name":"Clinical Center of Serbia Institute of Occupational and Radiological Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogoljub","family":"Peruni\u010di\u0107","sequence":"additional","affiliation":[{"name":"Clinical Center of Serbia Institute of Occupational and Radiological Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Farki\u0107","sequence":"additional","affiliation":[{"name":"Department of Occupational Health \u201cViskoza\u201d Loznica Yugoslavia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radmila","family":"Bani\u0107evi\u0107","sequence":"additional","affiliation":[{"name":"Clinical Center of Serbia Institute of Occupational and Radiological Health"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2003,5,30]]},"reference":[{"key":"e_1_2_1_2_1","volume-title":"Carbon disulfide, Environmental Health Criteria 10","author":"World Health Organization","year":"1979"},{"key":"e_1_2_1_3_1","first-page":"189","article-title":"Delpech and the origins of occupational psychiatry","volume":"47","author":"O'Flynn RR","year":"1990","journal-title":"Br J Ind Med"},{"key":"e_1_2_1_4_1","first-page":"764","volume-title":"Occupational Medicine","author":"Axelson O","year":"1994"},{"key":"e_1_2_1_5_1","first-page":"144","article-title":"Subjective and objective behavioral alterations in carbon disulfide workers","volume":"69","author":"Cassitto MG","year":"1978","journal-title":"Med Lav"},{"key":"e_1_2_1_6_1","first-page":"374","article-title":"Psychological picture of manifest and latent carbon disulfide poisoning","volume":"28","author":"H\u00e4nninen H","year":"1971","journal-title":"Brit J Industr Med"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00381035"},{"key":"e_1_2_1_8_1","first-page":"139","article-title":"Neuropsychological effects of occupational exposure to carbon disulfide and hydrogen sulfide","volume":"4","author":"De Fruyt F","year":"1998","journal-title":"Int J Environ Health"},{"key":"e_1_2_1_9_1","first-page":"473","article-title":"Environmental and biological monitoring in carbon disulfide exposure assessment","volume":"84","author":"Krstev S","year":"1993","journal-title":"Med Lav"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8260.1967.tb00530.x"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1973.00490290039003"},{"key":"e_1_2_1_12_1","volume-title":"Application cliniques et exp\u00e9rimentales. 2\u2010\u00e8me \u00e9dition fran\u00e7aise","author":"Benton AL","year":"1965"},{"key":"e_1_2_1_13_1","first-page":"249","volume-title":"Developments in Occupational Medicine","author":"Hogstedt C","year":"1980"},{"key":"e_1_2_1_14_1","first-page":"275","volume-title":"The Biological Monitoring of Exposure to Industrial Chemicals","author":"Hogstedt C","year":"1984"},{"key":"e_1_2_1_15_1","first-page":"197","volume-title":"Toxicology of Carbon Disulfide","author":"Toyama T","year":"1967"},{"key":"e_1_2_1_16_1","first-page":"219","volume-title":"Toxicology of Carbon Disulfide","author":"Goto S","year":"1967"},{"key":"e_1_2_1_17_1","first-page":"130","article-title":"Study of neurological and neurophysiological impairment in carbon disulfide workers","volume":"69","author":"Gilioli R","year":"1978","journal-title":"Med Lav"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.4700180104"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1992.tb04042.x"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1006\/enrs.1993.1145"},{"key":"e_1_2_1_21_1","first-page":"252","article-title":"The evaluation of the health state of the workers occupationally exposed to low concentration of carbon disulfide (CS2). 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