{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:06:11Z","timestamp":1791137171176,"version":"4.1.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2004,8,12]],"date-time":"2004-08-12T00:00:00Z","timestamp":1092268800000},"content-version":"vor","delay-in-days":42,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Occupational Health"],"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:p><jats:bold>Long\u2010Term Persistence of Chromosome Aberrations in Uranium Miners: Gabriella M\u00e9sz\u00e1ros, <jats:italic>et al.<\/jats:italic> \u201cFodor J\u00f3zsef\u201d National Public Health Center, \u201cFr\u00e9d\u00e9ric Joliot\u2010Curie\u201d National Research Institute for Radiobiology and Radiohygiene, Hungary<\/jats:bold>\u2014 Chromosome aberration analyses were performed on blood samples from 165 active underground uranium miners between 1981 and 1985. After decommissioning the mine in 1997 chromosome aberration analyses were also included in the medical laboratory investigations of health conditions of 141 subjects between 1998 and 2002 within the framework of a follow\u2010up\u2010study. The numerical data are presented as functions of the exposure categories expressed in working level month up to 600. In the active groups the dicentric level was 7 to 12 times higher than in the unexposed population, the acentrics also higher with more than an order of magnitude, the frequency of total aberrations\u2014including dicentrics, acentrics, rings, deletions, minits and numerical aberrations, i.e. both chromatid and chromosome type of aberrations were also well above the control level. In the group of former uranium miners although there were slight decreases in the dicentrics after 8 to 25 yr, the values were not significantly different from the values of active miners. The frequency of deletions was also maintained in the post\u2010mining period. The frequency of acentrics, however, decreased significantly, but even the lowest values remained 2\u20133 times higher than the values in the unexposed population. The possibility is suggested that for the long\u2010term persistence of cytogenetic alterations the permanent production and presence of clastogenic factors might be responsible. The comparison of the two datasets suggest a long\u2010term persistence of cytogenetic alterations above the population average values in a large fraction of persons investigated.<\/jats:p>","DOI":"10.1539\/joh.46.310","type":"journal-article","created":{"date-parts":[[2004,8,12]],"date-time":"2004-08-12T06:03:02Z","timestamp":1092290582000},"page":"310-315","source":"Crossref","is-referenced-by-count":27,"title":["Long\u2010Term Persistence of Chromosome Aberrations in Uranium Miners"],"prefix":"10.1093","volume":"46","author":[{"given":"Gabriella","family":"M\u00e9sz\u00e1ros","sequence":"first","affiliation":[{"name":"\u201cFodor J\u00f3zsef\u201d National Public Health Center \u201cFr\u00e9d\u00e9ric Joliot\u2010Curie\u201d National Research Institute for Radiobiology and Radiohygiene Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Bogn\u00e1r","sequence":"additional","affiliation":[{"name":"\u201cFodor J\u00f3zsef\u201d National Public Health Center \u201cFr\u00e9d\u00e9ric Joliot\u2010Curie\u201d National Research Institute for Radiobiology and Radiohygiene Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. J.","family":"K\u00f6teles","sequence":"additional","affiliation":[{"name":"\u201cFodor J\u00f3zsef\u201d National Public Health Center \u201cFr\u00e9d\u00e9ric Joliot\u2010Curie\u201d National Research Institute for Radiobiology and Radiohygiene Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,8,12]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"543","article-title":"Human cytogenetic damage as a predictor of cancer risk","author":"Sorsa M","year":"1992","journal-title":"IARC Sci Publ"},{"key":"e_1_2_1_3_1","first-page":"1619","article-title":"Chromosomal aberrations in lymphocytes predict human cancer independently of exposure to carcinogens","volume":"60","author":"Bonassi S","year":"2000","journal-title":"Cancer Res"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.2307\/3573600"},{"key":"e_1_2_1_5_1","volume-title":"IAEA, SM\u2010224\/310","author":"Brandom WF","year":"1978"},{"key":"e_1_2_1_6_1","first-page":"75","volume-title":"Workshop on Radiol","author":"K\u00f6teles GJ","year":"1988"},{"key":"e_1_2_1_7_1","first-page":"12","volume-title":"Annals of the ICRP","author":"Smith H","year":"1993"},{"key":"e_1_2_1_8_1","first-page":"32","volume-title":"Cytogenetic Analysis for Radiation Dose Assessment\u2014A Manual","author":"IAEA","year":"2001"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-7992(83)90162-8"},{"key":"e_1_2_1_10_1","first-page":"605","volume-title":"Radiation\u2010Induced Chromosome Damage in Man","author":"Tonomura A","year":"1983"},{"key":"e_1_2_1_11_1","first-page":"87","volume-title":"Abstract of 2nd Special Symposium on Natural Radiation Environment","author":"George KP","year":"1981"},{"key":"e_1_2_1_12_1","first-page":"73","volume-title":"Routine Use of Chromosome Analysis in Radiation Protection\u2014A Technical Document","author":"Lloyd DC","year":"1979"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01221035"},{"key":"e_1_2_1_14_1","first-page":"3","article-title":"Detection of clastogenic factors in oxidative stress associated diseases","volume":"4","author":"Emerit I","year":"1998","journal-title":"Centr Europ J Occup Environ Med"},{"key":"e_1_2_1_15_1","first-page":"433","volume-title":"Radiation\u2010Induced Chromosome Damage in Man","author":"Awa AA","year":"1983"},{"key":"e_1_2_1_16_1","first-page":"475","volume-title":"Radiation\u2010Induced Chromosome Damage in Man","author":"Ishihara T","year":"1983"},{"key":"e_1_2_1_17_1","first-page":"491","volume-title":"Radiation\u2010Induced Chromosome Aberrations in Man","author":"Buckton KE","year":"1983"},{"key":"e_1_2_1_18_1","first-page":"11","volume-title":"Sources and Effects of Ionizing Radiation","year":"1994"},{"key":"e_1_2_1_19_1","first-page":"156","article-title":"Lung cancer occurrence among uranium miners in P\u00e9cs","volume":"43","author":"S\u00e1ndor J","year":"1999","journal-title":"(in Hungarian) Eg\u00e9szs\u00e9gtudom\u00e1ny (Health Science)"},{"key":"e_1_2_1_20_1","first-page":"191","article-title":"Dose\u2010response relationship for radon exposure and lung cancer occurrence among Hungarian uranium miners","volume":"47","author":"S\u00e1ndor J","year":"2003","journal-title":"(in Hungarian) Eg\u00e9szs\u00e9gtudom\u00e1ny (Health Science)"},{"key":"e_1_2_1_21_1","volume-title":"European Commission R&D Project Cancer Risk Biomarkers, 5th Framework Program Quality of Life and Management of Living Resources, Key Action 4\u2014Environment and Health, Coordinated by H. Norppa"}],"container-title":["Journal of Occupational Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1539%2Fjoh.46.310","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1539\/joh.46.310","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1539\/joh.46.310","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T18:15:22Z","timestamp":1705083322000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/joh\/article\/46\/4\/310-315\/7271016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,7]]}},"alternative-id":["10.1539\/joh.46.310"],"URL":"https:\/\/doi.org\/10.1539\/joh.46.310","archive":["Portico"],"relation":{},"ISSN":["1341-9145","1348-9585"],"issn-type":[{"value":"1341-9145","type":"print"},{"value":"1348-9585","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,7]]}}}