{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T14:58:21Z","timestamp":1726757901511},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2004,2,9]],"date-time":"2004-02-09T00:00:00Z","timestamp":1076284800000},"content-version":"vor","delay-in-days":39,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Occupational Health"],"published-print":{"date-parts":[[2004,1]]},"abstract":"<jats:p><jats:bold>A 3\u2010Year Follow\u2010Up Study of Anti\u2010Legionella Antibodies in Users of Japanese 24\u2010Hour Hot Water Baths: Masahiro Irie, <jats:italic>et al.<\/jats:italic> Institute of Health Science, Kyushu University<\/jats:bold>\u2014Although it has been found that legionellae can exist in a 24\u2010h hot water bath (24HHWB), which has been used recently in Japan, whether longer use of the 24HHWB causes legionellosis is unclear. The present longitudinal study was conducted in 2000 to investigate the 3\u2010yr change in antibody titers in association with the continuous use, non\u2010use, or canceling the use of the 24HHWB, and possible factors relating to the antibody changes. Ninety\u2010two subjects (85 males and 7 females), who had had their anti\u2010Legionella pneumophila (Lp) serum antibody titers measured in our initial study in 1997 and consented to blood sampling 3 yr later, were selected as subjects. There were no clinical cases who had experienced Legionnaires\u2019 disease or Pontiac fever during the 3 yr. The continuous users showed no significant changes in antibody titers within 3 yr, whereas the continuous non\u2010users had a significant increase in antibody titers against the Lp serogroup (SG) 5 and 6. Eleven ex\u2010users of the 24HHWB showed a significant decrease in antibody titers against Lp SG 6. The changes in the 24HHWB use, job sector, stress coping strategies, and alcohol\u2010drinking habit were associated with the changes in antibody titers against Lp SG 1, 5 or 6. The anti\u2010Lp antibodies were considered to be IgM dominant. In conclusion, this study indicates that 24HHWB use by healthy subjects does not tend to result in a higher onset risk of legionellosis, even if it is continuously used for 3 yr, although 24HHWB use is likely to induce production of antibodies against legionellae.<\/jats:p>","DOI":"10.1539\/joh.46.68","type":"journal-article","created":{"date-parts":[[2004,3,23]],"date-time":"2004-03-23T06:02:36Z","timestamp":1080021756000},"page":"68-77","source":"Crossref","is-referenced-by-count":3,"title":["A 3\u2010Year Follow\u2010Up Study of Anti\u2010<i>Legionella<\/i> Antibodies in Users of Japanese 24\u2010Hour Hot Water Baths"],"prefix":"10.1093","volume":"46","author":[{"given":"Masahiro","family":"Irie","sequence":"first","affiliation":[{"name":"Institute of Health Science, Kyushu University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Microbiology School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Occupational Health Economics Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin\u2010ichi","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Bacteriology Graduate School of Medical Sciences, Kyushu University Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2004,2,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1202\/0002-8894(2000)061<0738:ROLD>2.0.CO;2"},{"key":"e_1_2_1_3_1","first-page":"84","article-title":"Legionnaires' disease: clinical, epidemiological, and public health perspectives","volume":"13","author":"Breiman RF","year":"1998","journal-title":"Semin Respir Infect"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1369-5274(99)80005-8"},{"key":"e_1_2_1_5_1","first-page":"100","article-title":"Immunologic response and pathophysiology of Legionella infection","volume":"13","author":"Friedman H","year":"1998","journal-title":"Semin Respir Infect"},{"key":"e_1_2_1_6_1","first-page":"221","article-title":"Contamination of 24 hr\u2010home bath water due to Legionella pneumophila and other bacteria. 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