{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:16:51Z","timestamp":1790860611435,"version":"4.1.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2005,4,12]],"date-time":"2005-04-12T00:00:00Z","timestamp":1113264000000},"content-version":"vor","delay-in-days":42,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Occupational Health"],"published-print":{"date-parts":[[2005,3]]},"abstract":"<jats:p><jats:bold>Cancer Incidence among Workers Potentially Exposed to Chlorinated Solvents in an Electronics Factory: Yung\u2010Ming Chang, <jats:italic>et al.<\/jats:italic> Graduate Institute of Life Sciences, National Defense Medical Center, National Defense University, Taiwan, R.O.C.<\/jats:bold>\u2014A retrospective cohort morbidity study based on standardized incidence ratios (SIRs) was conducted to investigate the possible association between exposure to chlorinated organic solvents and various types of cancers in an electronics factory. The cohort of the exposed group was retrieved from the Bureau of Labor Insurance (BLI) computer database records dating from 1978 through December 31, 1997. Person\u2010year accumulation began on the date of entry to the cohort, or January 1, 1979 (whichever came later), and ended on the closing date of the study (December 31, 1997), if alive without contracting any type of cancers, or the date of death, or the date of the cancer diagnosis. Vital status and cases of cancer of study subjects were determined from January 1, 1979 to December 31, 1997 by linking cohort data with the National Cancer Registry Database. The cancer incidence of the general population was used for comparison. After adjustment for age and calendar year, only SIR for breast cancer in the exposed female employees were significantly elevated when compared with the Taiwanese general population, based on the entire cohort without exclusion. The SIR of female breast cancer also showed a significant trend of period effect, but no significant dose\u2010response relationship on duration of employment. Although the total cancer as well as the cancer for trachea, bronchus and lung for the entire female cohort was not significantly elevated, trend analysis by calendar\u2010year interval suggested an upward trend. However, when duration of employment or latency was taken into consideration, no significantly elevated SIR was found for any type of cancer in either male or female exposed workers. In particular, the risk of female breast cancer was not indicated to be increased. No significant dose\u2010response relationship on duration of employment and secular trend was found for the above\u2010mentioned cancers. This study provides no evidence that exposure to chlorinated organic solvents at the electronics factory was associated with elevated human cancers. Dominant short\u2010term employees may bias the cancer risk toward false positive.<\/jats:p>","DOI":"10.1539\/joh.47.171","type":"journal-article","created":{"date-parts":[[2005,4,12]],"date-time":"2005-04-12T11:18:50Z","timestamp":1113304730000},"page":"171-180","source":"Crossref","is-referenced-by-count":20,"title":["Cancer Incidence among Workers Potentially Exposed to Chlorinated Solvents in an Electronics Factory"],"prefix":"10.1093","volume":"47","author":[{"given":"Yung\u2010Ming","family":"Chang","sequence":"first","affiliation":[{"name":"Graduate Institute of Life Sciences, National Defense Medical Center, National Defense University"},{"name":"North District Branch Office, Center for Disease Control, Department of Health Executive Yuan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi\u2010Fu","family":"Tai","sequence":"additional","affiliation":[{"name":"Institute of Occupational Safety and Health Council of Labor Affairs Executive Yuan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sweo\u2010Chung","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Occupational Safety and Health Council of Labor Affairs Executive Yuan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruey S.","family":"Lin","sequence":"additional","affiliation":[{"name":"College of Public Health, National Taiwan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fung\u2010Chang","family":"Sung","sequence":"additional","affiliation":[{"name":"College of Public Health, National Taiwan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tung\u2010Sheng","family":"Shih","sequence":"additional","affiliation":[{"name":"Institute of Occupational Safety and Health Council of Labor Affairs Executive Yuan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saou\u2010Hsing","family":"Liou","sequence":"additional","affiliation":[{"name":"Graduate Institute of Life Sciences, National Defense Medical Center, National Defense University"},{"name":"School of Public Health, National Defense Medical Center National Defense University"},{"name":"Division of Environmental Health and Occupational Medicine National Health Research Institutes"},{"name":"Institute of Occupational Safety and Health, Kaoshiung Medical University Taiwan R.O.C."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,4,12]]},"reference":[{"key":"e_1_2_1_2_1","volume-title":"Toxicological Profile for Tetrachloroethylene","author":"ATSDR","year":"1995"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.69.5.508"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a113562"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00378517"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.71.3.305"},{"key":"e_1_2_1_7_1","first-page":"162","article-title":"Cancer and other causes of death among a cohort of dry cleaners","volume":"47","author":"Blair A","year":"1990","journal-title":"Br J Ind Med"},{"key":"e_1_2_1_8_1","first-page":"818","article-title":"The mortality experience of army world war II chemical processing companies","volume":"23","author":"Norman JE","year":"1981","journal-title":"J Occup Med"},{"key":"e_1_2_1_9_1","first-page":"535","article-title":"Retrospective cohort mortality study of dry cleaning worker using perchloroethylene","volume":"29","author":"Brown DP","year":"1987","journal-title":"J Occup Med"},{"key":"e_1_2_1_10_1","first-page":"867","article-title":"Cancer mortality in female and male dry\u2010cleaning workers","volume":"36","author":"Ruder AM","year":"1994","journal-title":"JOM"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.74.11.1278"},{"key":"e_1_2_1_12_1","volume-title":"IARC Monographs on the Evaluation of Carcinogenic Risks to Human. 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