{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:03:57Z","timestamp":1790827437687,"version":"4.1.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2006,12,18]],"date-time":"2006-12-18T00:00:00Z","timestamp":1166400000000},"content-version":"vor","delay-in-days":47,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Occupational Health"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:p><jats:bold>Human Herpesvirus 6 Reactivation in Trichloroethylene\u2010exposed Workers Suffering from Generalized Skin Disorders Accompanied by Hepatic Dysfunction: Hanlin H<jats:sc>uang<\/jats:sc>, <jats:italic>et al<\/jats:italic>. Hospital for Occupational Diseases Control of Guangdong Province, P. R. of China<\/jats:bold>\u2014Idiosyncratic generalized skin disorders resembling serious drug hypersensitivities have reportedly occurred after occupational exposure to trichloroethylene. However, factors associated with the disorders remain unknown except for trichloroethylene exposure. This study aimed at clarifying whether infectious diseases contributed to the development of rash or hepatitis in patients with trichloroethylene\u2010related generalized skin disorders. Fifty\u2010nine patients consecutively hospitalized between March 2002 and December 2003 and 59 healthy exposed workers selected on an age\u2010matched basis in the patients' factories were enrolled in the study. Information on possible risk factors for rash and hepatitis was collected with structured checklists. Antibody titers were measured for hepatitis A, B and C viruses, Mycoplasma pneumoniae, herpes simplex viruses 1 and 2, Epstein\u2010Barr virus, cytomegalovirus, human herpesvirus 6, measles and rubella virus. Thirty\u2010six cases (59%) showed exfoliative dermatitis, 17 (28%) erythema multiforme, 4 (7%) Stevens\u2010Johnson syndrome, and 4 (7%) toxic epidermal necrolysis. Before the onset of rash, 16 (27%) cases had received medication prescribed for the preceding fever, a main first symptom of the disorders. Marked increases in anti\u2010human herpesvirus 6 IgG titer (\u2265256), which indicated viral reactivation, were noted in 14 (25%) patients, while no abnormal increase was detected in the controls (<jats:italic>p<\/jats:italic>&lt;0.001). Anti\u2010measles IgM titer was positive in 2 (7%) cases but not in the controls (<jats:italic>p<\/jats:italic>=0.49). The involvement of other known risk factors of rash or hepatitis was ruled out. These results suggest that part of trichloroethylene\u2010related generalized cutaneous disorders occurring in China and drug\u2010induced hypersensitivity syndrome overlap in terms of human herpesvirus 6 reactivation.<\/jats:p>","DOI":"10.1539\/joh.48.417","type":"journal-article","created":{"date-parts":[[2006,12,18]],"date-time":"2006-12-18T05:45:35Z","timestamp":1166420735000},"page":"417-423","source":"Crossref","is-referenced-by-count":55,"title":["Human Herpesvirus 6 Reactivation in Trichloroethylene\u2010exposed Workers Suffering from Generalized Skin Disorders Accompanied by Hepatic Dysfunction"],"prefix":"10.1093","volume":"48","author":[{"given":"Hanlin","family":"Huang","sequence":"first","affiliation":[{"name":"Hospital for Occupational Diseases Control of Guangdong Province P. 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