{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T03:41:22Z","timestamp":1783741282881,"version":"3.55.0"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2007,6,13]],"date-time":"2007-06-13T00:00:00Z","timestamp":1181692800000},"content-version":"vor","delay-in-days":43,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Occupational Health"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:p><jats:bold>Strong Acute Toxicity, Severe Hepatic Damage, Renal Injury and Abnormal Serum Electrolytes after Intravenous Administration of Cadmium Fluoride in Rats: Kazuya A<jats:sc>dachi<\/jats:sc>, <jats:italic>et al<\/jats:italic>. Department of Hygiene and Public Health, Osaka Medical College<\/jats:bold>\u2014Cadmium fluoride (CdF) is commonly used as an insulator for ulta high speed mass telecommunications equipment, and there is a considerable risk that industrial workers will inhale CdF particles. Despite the possibility that acute exposure can cause harmful systemic effects, there are no studies to date that address the health consequences of acute CdF exposure. This study therefore aimed to determine the acute lethal dose of CdF and its effects on various target organs, including the liver and kidney. We also determined the effect of CdF on serum electrolytes and acid\u2010base balance. The effective lethal dose was determined and dose\u2010response study was conducted after intravenous administration of CdF in rats. The 24 h LD<jats:sub>50<\/jats:sub> of CdF was determined to be 3.29 mg\/kg. The dose\u2010response study used doses of 1.34, 2.67, 4.01 mg\/kg CdF. Saline or sodium fluoride solution were used for controles. Severe hepatocellular injury was induced at doses greater than 2.67 mg\/kg, as demonstrated by AST and ALT activities greater than 1,500 IU\/l in rats injected with a dose of 4.01 mg\/kg. Acute renal failure was induced at doses greater than 2.67 mg\/kg. Decreased serum Ca, increased serum K and metabolic acidosis were induced at a dose of 4.01 mg\/kg. Decreased serum Ca was caused by exposure to ionized F. CdF has the strongest lethal and hepatic toxicity among all Cd containing compounds.<\/jats:p>","DOI":"10.1539\/joh.49.235","type":"journal-article","created":{"date-parts":[[2007,6,14]],"date-time":"2007-06-14T04:07:38Z","timestamp":1181794058000},"page":"235-241","source":"Crossref","is-referenced-by-count":18,"title":["Strong Acute Toxicity, Severe Hepatic Damage, Renal Injury and Abnormal Serum Electrolytes after Intravenous Administration of Cadmium Fluoride in Rats"],"prefix":"10.1093","volume":"49","author":[{"given":"Kazuya","family":"Adachi","sequence":"first","affiliation":[{"name":"Department of Hygiene and Public Health Osaka Medical College Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomotaro","family":"Dote","sequence":"additional","affiliation":[{"name":"Department of Hygiene and Public Health Osaka Medical College Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emi","family":"Dote","sequence":"additional","affiliation":[{"name":"Department of Hygiene and Public Health Osaka Medical College Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Go","family":"Mitsui","sequence":"additional","affiliation":[{"name":"Department of Hygiene and Public Health Osaka Medical College Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Kono","sequence":"additional","affiliation":[{"name":"Department of Hygiene and Public Health Osaka Medical College Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,6,13]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"1012","volume-title":"Toxicology","author":"Patty FA","year":"1962"},{"key":"e_1_2_1_3_1","volume-title":"Cadmium Markets and Trends","author":"Morrow H","year":"2005"},{"key":"e_1_2_1_4_1","first-page":"655","article-title":"The effects of acute cadmium administration in the liver and kidney of the rat. Light and electron microscopic studies","volume":"32","author":"Hoffmann EO","year":"1975","journal-title":"Lab Invest"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(90)90256-L"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00014633"},{"key":"e_1_2_1_7_1","first-page":"67","volume-title":"Evaluation of the impact of cadmium on the health of man","author":"National Library of Medicine","year":"1978"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1539\/joh.49.17"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(82)90013-8"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/000456329903600216"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0461(2000)14:2<110::AID-JBT7>3.0.CO;2-J"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1385\/BTER:104:3:223"},{"key":"e_1_2_1_13_1","first-page":"325","volume-title":"Emergency toxicology","author":"Barsky C","year":"1998"},{"key":"e_1_2_1_14_1","first-page":"210","article-title":"Acute renal damage dose response in rats to intravenous infusion of sodium fluoride","volume":"33","author":"Dote T","year":"2000","journal-title":"Fluoride"},{"key":"e_1_2_1_15_1","first-page":"25","volume-title":"A Toxicological and Epidemiological Appraisal, Vol. 2, Effects and Response","author":"Friberg L","year":"1986"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(05)81476-3"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.78.4.660"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(85)90181-4"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(89)90124-0"}],"container-title":["Journal of Occupational Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1539%2Fjoh.49.235","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1539\/joh.49.235","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1539\/joh.49.235","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T18:16:44Z","timestamp":1705083404000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/joh\/article\/49\/3\/235-241\/7269480"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["10.1539\/joh.49.235"],"URL":"https:\/\/doi.org\/10.1539\/joh.49.235","archive":["Portico"],"relation":{},"ISSN":["1341-9145","1348-9585"],"issn-type":[{"value":"1341-9145","type":"print"},{"value":"1348-9585","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,5]]}}}