{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T15:45:31Z","timestamp":1770479131467,"version":"3.49.0"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2008,8,7]],"date-time":"2008-08-07T00:00:00Z","timestamp":1218067200000},"content-version":"vor","delay-in-days":37,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Occupational Health"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:p><jats:bold>Abnormalities in Cadmium Fluoride Kinetics in Serum, Bile, and Urine after Single Intravenous Administration of Toxic Doses to Rats: Tomotaro D<jats:sc>ote<\/jats:sc>, <jats:italic>et al<\/jats:italic>. Department of Hygiene and Public Health, Osaka Medical College<\/jats:bold>\u2014Cadmium fluoride (CdF<jats:sub>2<\/jats:sub>, CdF for short) is the most lethal and hepatotoxic of all Cd\u2010containing compounds. The toxic effects of CdF appear to depend on its detoxification and elimination. This study was designed to determine the early dynamics of the absorption, systemic distribution, and metabolism of CdF. The kinetics of cadmium and fluoride were investigated in the blood, bile, and urine of rats as a model of accidental occupational exposure to CdF. The serum concentration\u2010time profiles measured after intravenous CdF (1.34, 2.67 or 4.01 mg\/ per kg body weight) administration were analyzed by compartmental modeling using the WinNonlin program. Bile and urine were collected for 300 min after the administration. The kinetic profiles indicate that the clearance of Cd was diminished in the 2.67 and 4.01 mg\/kg groups, leading to a persistently high serum Cd level. The mean total biliary excretions of Cd in the 2.67 and 4.01 mg\/kg groups were significantly higher than that in the 1.34 mg\/kg group. The abnormal kinetics of Cd was attributable to severe hepatic injury that diminished the capacity for Cd accumulation. The elimination of serum F was delayed in the 4.01 mg\/kg group. The mean urinary F excretion amount was not significantly higher in the 4.01 mg\/kg group than in the 2.67 mg\/kg group. The abnormal kinetics of F was attributable to nephrotoxicity that diminished its elimination from the kidney.<\/jats:p>","DOI":"10.1539\/joh.l8016","type":"journal-article","created":{"date-parts":[[2008,8,7]],"date-time":"2008-08-07T05:53:15Z","timestamp":1218088395000},"page":"339-347","source":"Crossref","is-referenced-by-count":3,"title":["Abnormalities in Cadmium Fluoride Kinetics in Serum, Bile, and Urine after Single Intravenous Administration of Toxic Doses to Rats"],"prefix":"10.1093","volume":"50","author":[{"given":"Tomotaro","family":"Dote","sequence":"first","affiliation":[{"name":"Department of Hygiene and Public Health Osaka Medical College Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuya","family":"Adachi","sequence":"additional","affiliation":[{"name":"Department of Hygiene and Public Health Osaka Medical College Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emi","family":"Yamadori","sequence":"additional","affiliation":[{"name":"Department of Hygiene and Public Health Osaka Medical College Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Imanishi","sequence":"additional","affiliation":[{"name":"Department of Hygiene and Public Health Osaka Medical College Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Tsuji","sequence":"additional","affiliation":[{"name":"Department of Hygiene and Public Health Osaka Medical College Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eri","family":"Tanida","sequence":"additional","affiliation":[{"name":"Department of Hygiene and Public Health Osaka Medical College Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Kono","sequence":"additional","affiliation":[{"name":"Department of Hygiene and Public Health Osaka Medical College Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2008,8,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1539\/joh.49.235"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1539\/joh.49.17"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(82)90013-8"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/15287397709529493"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00014633"},{"key":"e_1_2_1_7_1","first-page":"210","article-title":"Acute renal damage dose response in rats to intravenous infusion of sodium fluoride","volume":"33","author":"Dote T","year":"2000","journal-title":"Fluoride"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748233707076420"},{"key":"e_1_2_1_9_1","volume-title":"Clinical Toxicology of Commercial Products","author":"Gibaldi M","year":"1982"},{"key":"e_1_2_1_10_1","first-page":"253","article-title":"Bile secretion and bile composition in the freely moving, unanaesthetized rat with a permanent biliary drainage: influence of food intake on bile flow","volume":"55","author":"Vonk RJ","year":"1978","journal-title":"Clin Sci Mol Med"},{"key":"e_1_2_1_11_1","first-page":"79","article-title":"Kinetics of cadmium nitrate in serum, bile, and urine after single intravenous administration of toxic doses","volume":"18","author":"Dote E","year":"2007","journal-title":"Biom Res Trace Elem"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(86)90139-6"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-008X(78)80005-2"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(89)90124-0"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.15.8428"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.06.085"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0461(2000)14:2<110::AID-JBT7>3.0.CO;2-J"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-007-0044-6"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1385\/BTER:104:3:223"},{"key":"e_1_2_1_20_1","first-page":"822","volume-title":"Casarett & Doull's Toxicology: The Basic Science of Poisons","author":"Curtis DK","year":"2001"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(94)02875-U"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(85)90181-4"}],"container-title":["Journal of Occupational Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1539%2Fjoh.L8016","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1539\/joh.L8016","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1539\/joh.L8016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T18:17:53Z","timestamp":1705083473000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/joh\/article\/50\/4\/339-347\/7270045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["10.1539\/joh.L8016"],"URL":"https:\/\/doi.org\/10.1539\/joh.l8016","archive":["Portico"],"relation":{},"ISSN":["1341-9145","1348-9585"],"issn-type":[{"value":"1341-9145","type":"print"},{"value":"1348-9585","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,7]]}}}