{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T01:20:53Z","timestamp":1771550453402,"version":"3.50.1"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2009,2,11]],"date-time":"2009-02-11T00:00:00Z","timestamp":1234310400000},"content-version":"vor","delay-in-days":41,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Occupational Health"],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:sec><jats:label\/><jats:p><jats:bold>Di\u2010(2\u2010ethylhexyl) Phthalate Upregulates ATF3 Expression and Suppresses Apoptosis in Mouse Genital Tubercle: Xing L<jats:sc>iu<\/jats:sc>, <jats:italic>et al<\/jats:italic>. Department of Pediatric Urology, Chongqing Children's Hospital, Chongqing Medical University, China<\/jats:bold><\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the effect of di\u2010(2\u2010ethylhexyl) phthalate (DEHP) on the expression of activating transcription factor 3 (ATF3) and apoptosis of fetal mouse genital tubercle (GT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this developmental toxicity study, pregnant C57BL\/6 mice were exposed to corn oil or DEHP (100 or 500 mg\/kg\/ day) from embryonic day 12 (ED12) to ED16. Apoptosis was characterized by Terminal transferase dUTP nick end labeling (TUNEL) assay. Using RT\u2010PCR and western blot, the expressions of ATF3 and apoptosis\u2010related genes (P53, Bcl\u20102 and Bax) were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Apoptosis of fetal mouse GT cells notably decreased after DEHP treatment. DEHP activated ATF3 both at the mRNA and protein levels in GT. Furthermore, pro\u2010apoptotic P53 was down\u2010regulated and the ratio of anti\u2010apoptotic (Bcl\u20102)\/pro\u2010apoptotic (Bax) was not significantly changed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results suggest that DEHP may induce external genital defects via a mechanism involving apoptosis, which might correlate with the regulation of ATF3 and P53 expressions.<\/jats:p><\/jats:sec>","DOI":"10.1539\/joh.l8091","type":"journal-article","created":{"date-parts":[[2009,2,18]],"date-time":"2009-02-18T06:06:40Z","timestamp":1234937200000},"page":"57-63","source":"Crossref","is-referenced-by-count":15,"title":["Di\u2010(2\u2010ethylhexyl) Phthalate Upregulates ATF3 Expression and Suppresses Apoptosis in Mouse Genital Tubercle"],"prefix":"10.1093","volume":"51","author":[{"given":"Xing","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Pediatric Urology Chongqing Children's Hospital 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