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OECD guideline for testing of chemicals. Carcinogenicity studies. Original adopted 12 May, 1981. Last adopted 7 September, 2009 Paris (France) [Online]. 2009 [cited 2014 Nov 11]; Available from: URL: http:\/\/www.oecd-ilibrary.org\/environment\/test-no-451-carcinogenicity-studies_9789264071186-en"},{"key":"13","doi-asserted-by":"crossref","unstructured":"16) Haseman JK, Hailey JR, Morris RW. Spontaneous neoplasm incidences in Fischer 344 rats and B6C3F<sub>1<\/sub> mice in two-year carcinogenicity studies: a National Toxicology Program update. Toxicol Pathol 1998; 26: 428\u201341.","DOI":"10.1177\/019262339802600318"},{"key":"14","doi-asserted-by":"crossref","unstructured":"18) Ando R, Nakamura A, Nagatani M, et al. Comparison of past and recent historical control data in relation to spontaneous tumors during carcinogenicity testing in Fischer 344 rats. 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