{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T22:51:14Z","timestamp":1784242274509,"version":"3.55.0"},"reference-count":33,"publisher":"Japan Society of Smooth Muscle Research","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Smooth Muscle Res","J. Smooth Muscle Res."],"published-print":{"date-parts":[[2009]]},"DOI":"10.1540\/jsmr.45.15","type":"journal-article","created":{"date-parts":[[2009,4,20]],"date-time":"2009-04-20T05:55:49Z","timestamp":1240206949000},"page":"15-23","source":"Crossref","is-referenced-by-count":72,"title":["Pathophysiology underlying irritable bowel syndrome -From the viewpoint of dysfunction of autonomic nervous system activity-"],"prefix":"10.1540","volume":"45","author":[{"given":"Noriaki","family":"Manabe","sequence":"first","affiliation":[{"name":"Division of Endoscopy and Ultrasonography, Department of Clinical Pathology and Laboratory Medicine; Kawasaki Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine; Kawasaki Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiro","family":"Hata","sequence":"additional","affiliation":[{"name":"Division of Endoscopy and Ultrasonography, Department of Clinical Pathology and Laboratory Medicine; Kawasaki Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Kusunoki","sequence":"additional","affiliation":[{"name":"Department of Health Care Medicine; Kawasaki Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Haruma","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine; Kawasaki Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"435","reference":[{"key":"1","unstructured":"Abe, M., Ando, Y., Higashi, K. and Kano, T. (1996). Non-neurogenic periodic fluctuations in heart rate and vasomotion appearing in familial amyloid polyneuropath (FAP) type 1 (Met30). J. Auton. Nerv. Syst. 60: 71-75."},{"key":"2","unstructured":"Adeyemi, E.O.A., Desai, K.D., Towsey, M. and Ghista, D. (1999). Characterization of autonomic dysfunction in patients with irritable bowel syndrome by means of heart rate variability studies. Am. J. Gastroenterol. 94: 816-823."},{"key":"3","unstructured":"Aggarawal, A., Cutts, T.F., Abell, T.L., Cardoso, S., Familoni, B., Bremer, J. and Karas, J. (1994). Predominant symptoms in irritable bowel syndrome correlate with specific autonomic nervous abnormalities. Gastroenterol. 106: 945-950."},{"key":"4","unstructured":"Bockus, H.L., Bank, J. and Wilkinson, S.A. (1928). Neurogenic mucous colitis. Am. J. Med. Sci. 176: 813-829."},{"key":"5","unstructured":"Bharucha, A.E., Camilleri, M., Low, P.A. and Zinsmeister, A.R. (1993). Autonomic dysfunction in gastrointestinal motility disorders. Gut 34: 397-401."},{"key":"6","unstructured":"Buysschaert, M., Donckier, J., Dive, A., Ketelslegers, J.M. and Kambert, A.E. (1985). Gastric acid and pancreatic polypeptide responses to sham feeding are impaired in diabetic subjects with autonomic neuropathy. Diabetes 34: 1181-1185."},{"key":"7","unstructured":"Chang, L., Mayer, E.A., Labus, J.S., Schmulson, M., Lee, O.Y., Olivas, T.I., Stains, J. and Naliboff, B.D. (2006). Effect of sex on perception of rectosigmoid stimuli in irritable bowel syndrome. Am. J. Physiol. 291: R277-R284."},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.36603"},{"key":"9","unstructured":"Drossman, D.A., Powel, D.W. and Sessions, J.T. (1977). The irritable bowel syndrome. Gastroenterol. 73: 811-822."},{"key":"10","unstructured":"Drossman, D.A., Camilleri, M., Mayer, E.A. and Whitehead, W.E. (2002). AGA technical review on irritable bowel syndrome. Gastroenterol. 123: 2108-2131."},{"key":"11","unstructured":"Elenkov, U., Wilder, R.L. and Chrousos, G.P. (2000). The sympathetic nerve-an integrative interface between two supersystems: the brain and immune system. Pharmacol. Rev. 52: 585-638."},{"key":"12","unstructured":"Elsenbruch, S. and Orr, W.C. (2001). Diarrhea- and constipation-predominant IBS patients differ in postprandial autonomic and cortisol responses. Am. J. Gastroenterol. 96: 460-466."},{"key":"13","unstructured":"Emmanuel, A.V. and Kamm, M.A. (2000). Laser Doppler flowmetry as a measure of extrinsic colonic innervation in functional bowel disease. Gut 46: 212-217."},{"key":"14","unstructured":"Esler, M.D. and Goulston, K.J. (1973). Levels of anxiety in colonic disorders. N. Engl. J. Med. 288: 12-16."},{"key":"15","unstructured":"Everhart, J.E. and Renault, P.F. (1991). Irritable bowel syndrome in office based practice in the United States. Gastroenterol. 100: 998-1005."},{"key":"16","unstructured":"Hansen, M.B. (2003). The enteric nervous system I: organization and classification. Pharmacol. Toxicol. 92: 105-113."},{"key":"17","unstructured":"Heitkemper, M., Jarrett, M., Cain, K., Shaver, J., Bond, E., Woods, N.F. and Walker, E. (1996). Increased urine catecholamines and cortisol in women with irritable bowel syndrome. Am. J. Gastroenterol. 5: 906-913."},{"key":"18","unstructured":"Iovino, P., Azpiroz, F., Domingo, E. and Malagelada, J.R. (1995). The symptomatic nervous system modulates perception and reflex responses to gut distension in human. Gastroenterol. 108: 680-686."},{"key":"19","unstructured":"Karling, P., Nyhlin, H., Wiklund, U., Sj&ouml;berg, M., Olofsson, B.O. and Bjerle, P. (1998). Spectral analysis of heart rate variability in patients with irritable bowel syndrome. Scand. J. Gastroenterol. 33: 572-576."},{"key":"20","unstructured":"Longstreth, G.F. and Wolde-Tsadik, G. (1993). Irritable bowel-type symptoms in HMO examinees. Prevalence, demographics, and clinical correlates. Dig. Dis. Sci. 38: 1581-1589."},{"key":"21","doi-asserted-by":"crossref","unstructured":"Malagelada, J.-R. and Azpiroz, F. (1989). Determinants of gastric emptying and transit in the small intestine. In: Handbook of Physiology, Section 6: Tthe Gastrointestinal System. Volume 1: Motility and Circulation, 2nd ed., eds. by S.G. Schultz, J.D. Wood, B.B. Rauner, American Physiological Society, Bethesda, MD, pp. 909-937.","DOI":"10.1002\/cphy.cp060123"},{"key":"22","unstructured":"Mayer, E.A. and Gebhart, G.F. (1994). Basic and clinical aspects of visceral hyperalgia. Gastroenterol. 107: 271-293."},{"key":"23","unstructured":"Mayer, E.A., Berman, S., Chang, L. and Naliboff, B.D. (2004). Sex-based differences in gastrointestinal pain. Eur. J. Pain 8: 451-463."},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00400-1"},{"key":"25","unstructured":"Pan, G., Lu, S., Ke, M., Han, S., Guo, H. and Fang, X. (2000). Epidemiologic study of the irritable bowel syndrome in Beijing: stratified randomized study by cluster sampling. Chin. Med. J. 113: 35-39."},{"key":"26","unstructured":"Raamat, R., Jagomagi, K. and Kingisepp, P.-H. (2002). Simultaneous recording of fingertip skin blood flow changes by multiprobe laser Doppler flowmetry and frequency-corrected thermal clearance. Microvasc. Res. 64: 214-219."},{"key":"27","unstructured":"Robert, J.J.T., Elsenbruch, S. and Whitehead, W.C. (2006). Sleep-related autonomic disturbances in symptom subgroups of women with irritable bowel syndrome. Dig. Dis. Sci. 51: 2121-2127."},{"key":"28","unstructured":"Shiihara, Y., Hirota, A. and Kibayashi, Y. (1999). Skin blood flow responses during sleep by laser Doppler flowmetry. Psychiat. Clin. Neurosci. 53: 117-119."},{"key":"29","unstructured":"Spanziani, R., Bayati, A., Redmond, K., Bajaj, H., Bienenstock, J., Collins, S.M. and Kamath, M.V. (2008). Vagal dysfunction in irritable bowel syndrome assessed by rectal distension and baroreceptor sensitivity. Neurogastroenterol. Motil. 20: 336-342."},{"key":"30","unstructured":"Tanaka, T., Manabe, N., Hata, J., Kusunoki, H., Ishii, M., Sato, M., Kamada, T., Shiotani, A. and Haruma, K. (2007). Characterization of autonomic dysfunction in patients with irritable bowel syndrome using fingertip blood flow. Neurogastroenterol. Motil. 20: 498-504."},{"key":"31","unstructured":"Tillish, K., Mayer, E.A., Labus, J.S., Stains, J., Chang, L. and Naliboff, B.D. (2005). Sex specific alterations in autonomic function among patients with irritable bowel syndrome. Gut 54: 1396-1401."},{"key":"32","unstructured":"van Orshoven, N.P., Andriesse, G.I., van Schelven, L.J., Smout, A.J., Akkermans, L.M. and Oey, P.L. (2006). Subtle involvement of the parasympathetic nervous system in patients with irritable bowel syndrome. Clin. Auton. Res. 16: 33-39."},{"key":"33","unstructured":"Viramontes, B., Camilleri, M., McKinzie, S., Pardi, D.S., Burton, D. and Thomforde, G.M. (2001). Gender-related differences in slowing colonic transit by a 5-HT3 antagonist in subjects with diarrhea-predominant irritable syndrome. Am. J. Gastroenterol. 96: 2671-2679."}],"container-title":["Journal of Smooth Muscle Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/jsmr\/45\/1\/45_1_15\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T21:45:41Z","timestamp":1684964741000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/jsmr\/45\/1\/45_1_15\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.1540\/jsmr.45.15","relation":{},"ISSN":["0916-8737","1884-8796"],"issn-type":[{"value":"0916-8737","type":"print"},{"value":"1884-8796","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}