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Am J Dig Dis. 1978; 23(10): 929&ndash;35.","DOI":"10.1007\/BF01072469"},{"key":"2","unstructured":"2. Itoh Z, Honda R, Hiwatashi K, Takeuchi S, Aizawa I, Takayanagi R, Couch EF. Motilin-induced mechanical activity in the canine alimentary tract. Scand J Gastroenterol Suppl. 1976; 39: 93&ndash;110."},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Hall KE, Greenberg GR, El-Sharkawy TY, Diamant NE. Vagal control of migrating motor complex-related peaks in canine plasma motilin, pancreatic polypeptide, and gastrin. Can J Physiol Pharmacol. 1983; 61(11): 1289&ndash;98.","DOI":"10.1139\/y83-186"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Vantrappen G, Janssens J, Peeters TL, Bloom SR, Christofides ND, Hellemans J. Motilin and the interdigestive migrating motor complex in man. Dig Dis Sci. 1979; 24(7): 497&ndash;500.","DOI":"10.1007\/BF01489315"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Janssens J, Vantrappen G, Peeters TL. The activity front of the migrating motor complex of the human stomach but not of the small intestine is motilin-dependent. Regul Pept. 1983; 6(4): 363&ndash;9.","DOI":"10.1016\/0167-0115(83)90265-3"},{"key":"6","unstructured":"6. Wingate DL, Ruppin H, Green WE, Thompson HH, Domschke W, Wunsch E, Demling L, Ritchie HD. Motilin-induced electrical activity in the canine gastrointestinal tract. Scand J Gastroenterol Suppl. 1976; 39: 111&ndash;8."},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Depoortere I, De Winter B, Thijs T, De Man J, Pelckmans P, Peeters T. Comparison of the gastroprokinetic effects of ghrelin, GHRP-6 and motilin in rats in vivo and in vitro. Eur J Pharmacol. 2005; 515(1&ndash;3): 160&ndash;8.","DOI":"10.1016\/j.ejphar.2005.04.008"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999; 402(6762): 656&ndash;60.","DOI":"10.1038\/45230"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Tomasetto C, Karam SM, Ribieras S, Masson R, Lefebvre O, Staub A, Alexander G, Chenard MP, Rio MC. Identification and characterization of a novel gastric peptide hormone: the motilin-related peptide. Gastroenterology. 2000; 119(2): 395&ndash;405.","DOI":"10.1053\/gast.2000.9371"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Asakawa A, Inui A, Kaga T, Yuzuriha H, Nagata T, Ueno N, Makino S, Fujimiya M, Niijima A, Fujino MA, Kasuga M. Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin. Gastroenterology. 2001; 120(2): 337&ndash;45.","DOI":"10.1053\/gast.2001.22158"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Fujino K, Inui A, Asakawa A, Kihara N, Fujimura M, Fujimiya M. Ghrelin induces fasted motor activity of the gastrointestinal tract in conscious fed rats. J Physiol. 2003; 550(Pt 1): 227&ndash;40.","DOI":"10.1113\/jphysiol.2003.040600"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Zheng J, Ariga H, Taniguchi H, Ludwig K, Takahashi T. Ghrelin regulates gastric phase III-like contractions in freely moving conscious mice. Neurogastroenterol Motil. 2009; 21(1): 78&ndash;84.","DOI":"10.1111\/j.1365-2982.2008.01179.x"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Ariga H, Tsukamoto K, Chen C, Mantyh C, Pappas TN, Takahashi T. Endogenous acyl ghrelin is involved in mediating spontaneous phase III-like contractions of the rat stomach. Neurogastroenterol Motil. 2007; 19(8): 675&ndash;80.","DOI":"10.1111\/j.1365-2982.2007.00945.x"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Ohno T, Kamiyama Y, Aihara R, Nakabayashi T, Mochiki E, Asao T, Kuwano H. Ghrelin does not stimulate gastrointestinal motility and gastric emptying: an experimental study of conscious dogs. Neurogastroenterol Motil. 2006; 18(2): 129&ndash;35.","DOI":"10.1111\/j.1365-2982.2005.00747.x"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Kobayashi S, Iwanaga T, Fujita T, Yanaihara N. Do enterochromaffin (EC) cells contain motilin? Arch Histol Jpn. 1980; 43(2): 85&ndash;98.","DOI":"10.1679\/aohc1950.43.85"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Suzuki H, Mochiki E, Haga N, Shimura T, Itoh Z, Kuwano H. Effect of duodenectomy on gastric motility and gastric hormones in dogs. Ann Surg. 2001; 233(3): 353&ndash;9.","DOI":"10.1097\/00000658-200103000-00008"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Goll R, Nielsen SH, Holst JJ: Regulation of motilin release from isolated perfused pig duodenum. Digestion. 1996; 57(5): 341&ndash;8.","DOI":"10.1159\/000201355"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Poitras P, Dumont A, Cuber JC, Trudel L: Cholinergic regulation of motilin release from isolated canine intestinal cells. Peptides. 1993; 14(2): 207&ndash;13.","DOI":"10.1016\/0196-9781(93)90031-B"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Yamada T, Mizumoto A, Satoh M, Haga N, Itoh Z. Muscarinic control of phase III contractions and motilin release in dogs. Peptides. 1997; 18(5): 673&ndash;80.","DOI":"10.1016\/S0196-9781(97)00132-0"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Itoh Z. Motilin and clinical application. Peptides. 1997; 18(4):593&ndash;608.","DOI":"10.1016\/S0196-9781(96)00333-6"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Yoshiya K, Yamamura T, Ishikawa Y, Utsunomiya J, Mori K, Seino Y, Imura H, Yanaihara N. The failure of truncal vagotomy to affect motilin release in dogs. J Surg Res. 1985; 38(3): 263&ndash;6.","DOI":"10.1016\/0022-4804(85)90036-8"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Mochiki E, Satoh M, Tamura T, Haga N, Suzuki H, Mizumoto A, Sakai T, Itoh Z. Exogenous motilin stimulates endogenous release of motilin through cholinergic muscarinic pathways in the dog. Gastroenterology. 1996; 111(6): 1456&ndash;64.","DOI":"10.1016\/S0016-5085(96)70006-9"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Mochiki E, Inui A, Satoh M, Mizumoto A, Itoh Z. Motilin is a biosignal controlling cyclic release of pancreatic polypeptide via the vagus in fasted dogs. Am J Physiol. 1997; 272(2 Pt 1): G224&ndash;32.","DOI":"10.1152\/ajpgi.1997.272.2.G224"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Sarna S, Chey WY, Condon RE, Dodds WJ, Myers T, Chang TM. Cause-and-effect relationship between motilin and migrating myoelectric complexes. Am J Physiol. 1983; 245(2): G277&ndash;84.","DOI":"10.1152\/ajpgi.1983.245.2.G277"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Mizumoto A, Sano I, Matsunaga Y, Yamamoto O, Itoh Z, Ohshima K. Mechanism of motilin-induced contractions in isolated perfused canine stomach. Gastroenterology. 1993; 105(2): 425&ndash;32.","DOI":"10.1016\/0016-5085(93)90716-P"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Van Assche G, Depoortere I, Thijs T, Janssens JJ, Peeters TL. Concentration-dependent stimulation of cholinergic motor nerves or smooth muscle by [Nle13]motilin in the isolated rabbit gastric antrum. Eur J Pharmacol. 1997; 337(2&ndash;3): 267&ndash;74.","DOI":"10.1016\/S0014-2999(97)01317-4"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Takeshita E, Matsuura B, Dong M, Miller LJ, Matsui H, Onji M. Molecular characterization and distribution of motilin family receptors in the human gastrointestinal tract. J Gastroenterol. 2006; 41(3): 223&ndash;30.","DOI":"10.1007\/s00535-005-1739-0"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Chung SA, Valdez DT, Diamant NE. Adrenergic blockage does not restore the canine gastric migrating motor complex during vagal blockade. Gastroenterology. 1992; 103(5): 1491&ndash;7.","DOI":"10.1016\/0016-5085(92)91169-5"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Tanaka T, Kendrick ML, Zyromski NJ, Meile T, Sarr MG. Vagal innervation modulates motor pattern but not initiation of canine gastric migrating motor complex. Am J Physiol Gastrointest Liver Physiol. 2001; 281(1): G283&ndash;92.","DOI":"10.1152\/ajpgi.2001.281.1.G283"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Yoshida N, Mizumoto A, Iwanaga Y, Itoh Z: Effects of 5-hydroxytryptamine 3 receptor antagonists on gastrointestinal motor activity in conscious dogs. J Pharmacol Exp Ther. 1991; 256(1): 272&ndash;8.","DOI":"10.1016\/S0022-3565(25)23028-2"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Haga N, Mizumoto A, Satoh M, Mochiki E, Mizusawa F, Ohshima K, Itoh Z. Role of endogenous 5-hydroxytryptamine in the regulation of gastric contractions by motilin in dogs. Am J Physiol. 1996; 270(1 Pt 1): G20&ndash;8.","DOI":"10.1152\/ajpgi.1996.270.1.G20"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Wilmer A, Tack J, Coremans G, Janssens J, Peeters T, Vantrappen G. 5-hydroxytryptamine-3 receptors are involved in the initiation of gastric phase-3 motor activity in humans. Gastroenterology. 1993; 105(3): 773&ndash;80.","DOI":"10.1016\/0016-5085(93)90895-J"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Leslie RA. Comparative aspects of the area postrema: fine-structural considerations help to determine its function. Cell Mol Neurobiol. 1986; 6(2): 95&ndash;120.","DOI":"10.1007\/BF00711065"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Poitras P, Steinbach JH, VanDeventer G, Code CF, Walsh JH. Motilin-independent ectopic fronts of the interdigestive myoelectric complex in dogs. Am J Physiol. 1980; 239(3): G215&ndash;20.","DOI":"10.1152\/ajpgi.1980.239.3.G215"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Lee KY, Chang TM, Chey WY. Effect of rabbit antimotilin serum on myoelectric activity and plasma motilin concentration in fasting dog. Am J Physiol. 1983; 245(4):G547&ndash;53.","DOI":"10.1152\/ajpgi.1983.245.4.G547"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Itoh Z, Aizawa I, Honda R, Takeuchi S, Mori K. Regular and irregular cycles of interdigestive contractions in the stomach. Am J Physiol 1980; 238(2): G85&ndash;90.","DOI":"10.1152\/ajpgi.1980.238.2.G85"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Itoh Z, Honda R, Aizawa I. Diurnal pH changes in duodenum of conscious dogs. Am J Physiol 1980; 238(2): G91&ndash;6.","DOI":"10.1152\/ajpgi.1980.238.2.G91"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Itoh Z, Takahashi I. Periodic contractions of the canine gallbladder during the interdigestive state. Am J Physiol. 1981; 240(2): G183&ndash;9.","DOI":"10.1152\/ajpgi.1981.240.2.G183"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Nakajima H, Mochiki E, Zietlow A, Ludwig K, Takahashi T. Mechanism of interdigestive migrating motor complex in conscious dogs. J Gastroenterol. 2010; 45(5): 506&ndash;14.","DOI":"10.1007\/s00535-009-0190-z"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Ormsbee HS, 3rd, Silber DA, Hardy FE, Jr. Serotonin regulation of the canine migrating motor complex. J Pharmacol Exp Ther. 1984; 231(2): 436&ndash;40.","DOI":"10.1016\/S0022-3565(25)21692-5"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Gorard DA, Libby GW, Farthing MJ. 5-Hydroxytryptamine and human small intestinal motility: effect of inhibiting 5-hydroxytryptamine reuptake. Gut. 1994; 35(4): 496&ndash;500.","DOI":"10.1136\/gut.35.4.496"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Gershon MD, Drakontides AB, Ross LL. Serotonin: Synthesis and Release from the Myenteric Plexus of the Mouse Intestine. Science. 1965; 149(3680): 197&ndash;9.","DOI":"10.1126\/science.149.3680.197"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Gershon MD. Nerves, reflexes, and the enteric nervous system: pathogenesis of the irritable bowel syndrome. J Clin Gastroenterol. 2005; 39(5 Suppl): S184&ndash;93.","DOI":"10.1097\/01.mcg.0000156403.37240.30"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44. Ahlman H, DeMagistris L, Zinner M, Jaffe BM. Release of immunoreactive serotonin into the lumen of the feline gut in response to vagal nerve stimulation. Science. 1981; 213(4513): 1254&ndash;5.","DOI":"10.1126\/science.6168020"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45. Gronstad K, Dahlstrom A, Florence L, Zinner MJ, Ahlman J, Jaffe BM. Regulatory mechanisms in endoluminal release of serotonin and substance P from feline jejunum. Dig Dis Sci. 1987; 32(4): 393&ndash;400.","DOI":"10.1007\/BF01296293"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46. Kellum J, McCabe M, Schneier J, Donowitz M. Neural control of acid-induced serotonin release from rabbit duodenum. Am J Physiol. 1983; 245(6): G824&ndash;31.","DOI":"10.1152\/ajpgi.1983.245.6.G824"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47. Ferrara A, Zinner MJ, Jaffe BM. Intraluminal release of serotonin, substance P, and gastrin in the canine small intestine. Dig Dis Sci. 1987; 32(3): 289&ndash;94.","DOI":"10.1007\/BF01297056"},{"key":"48","unstructured":"48. Larsson I. Studies on the extrinsic neural control of serotonin release from the small intestine. Acta Physiol Scand Suppl. 1981; 499: 1&ndash;43."},{"key":"49","doi-asserted-by":"crossref","unstructured":"49. Zinner MJ, Jaffe BM, DeMagistris L, Dahlstrom A, Ahlman H. Effect of cervical and thoracic vagal stimulation on luminal serotonin release and regional blood flow in cats. Gastroenterology. 1982; 82(6): 1403&ndash;8.","DOI":"10.1016\/0016-5085(82)90076-2"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50. Tsukamoto K, Ariga H, Mantyh C, Pappas TN, Yanagi H, Yamamura T, Takahashi T. Luminally released serotonin stimulates colonic motility and accelerates colonic transit in rats. Am J Physiol Regul Integr Comp Physiol. 2007; 293(1): R64&ndash;9.","DOI":"10.1152\/ajpregu.00856.2006"},{"key":"51","doi-asserted-by":"crossref","unstructured":"51. Fujimiya M, Okumiya K, Kuwahara A. Immunoelectron microscopic study of the luminal release of serotonin from rat enterochromaffin cells induced by high intraluminal pressure. Histochem Cell Biol. 1997; 108(2): 105&ndash;13.","DOI":"10.1007\/s004180050151"},{"key":"52","doi-asserted-by":"crossref","unstructured":"52. Cooke HJ, Montakhab M, Wade PR, Wood JD. Transmural fluxes of 5-hydroxytryptamine in guinea pig ileum. Am J Physiol. 1983; 244(4): G421&ndash;5.","DOI":"10.1152\/ajpgi.1983.244.4.G421"},{"key":"53","doi-asserted-by":"crossref","unstructured":"53. Martel F, Monteiro R, Lemos C, Vieira-Coelho MA. In vitro and in vivo effect of fluoxetine on the permeability of 3H-serotonin across rat intestine. Can J Physiol Pharmacol. 2004; 82(11): 940&ndash;50.","DOI":"10.1139\/y04-083"},{"key":"54","doi-asserted-by":"crossref","unstructured":"54. Fukumoto S, Tatewaki M, Yamada T, Fujimiya M, Mantyh C, Voss M, Eubanks S, Harris M, Pappas TN, Takahashi T. Short-chain fatty acids stimulate colonic transit via intraluminal 5-HT release in rats. Am J Physiol Regul Integr Comp Physiol. 2003; 284(5): R1269&ndash;76.","DOI":"10.1152\/ajpregu.00442.2002"},{"key":"55","doi-asserted-by":"crossref","unstructured":"55. Foxx-Orenstein AE, Kuemmerle JF, Grider JR. Distinct 5-HT receptors mediate the peristaltic reflex induced by mucosal stimuli in human and guinea pig intestine. Gastroenterology. 1996; 111(5): 1281&ndash;90.","DOI":"10.1053\/gast.1996.v111.pm8898642"},{"key":"56","doi-asserted-by":"crossref","unstructured":"56. Bertrand PP, Kunze WA, Furness JB, Bornstein JC. The terminals of myenteric intrinsic primary afferent neurons of the guinea-pig ileum are excited by 5-hydroxytryptamine acting at 5-hydroxytryptamine-3 receptors. Neuroscience. 2000; 101(2): 459&ndash;69.","DOI":"10.1016\/S0306-4522(00)00363-8"},{"key":"57","doi-asserted-by":"crossref","unstructured":"57. Hicks GA, Coldwell JR, Schindler M, Ward PA, Jenkins D, Lynn PA, Humphrey PP, Blackshaw LA. Excitation of rat colonic afferent fibres by 5-HT(3) receptors. J Physiol. 2002; 544(Pt 3): 861&ndash;9.","DOI":"10.1113\/jphysiol.2002.025452"},{"key":"58","doi-asserted-by":"crossref","unstructured":"58. Glatzle J, Sternini C, Robin C, Zittel TT, Wong H, Reeve JR, Jr., Raybould HE. Expression of 5-HT<sub>3<\/sub> receptors in the rat gastrointestinal tract. Gastroenterology. 2002; 123(1): 217&ndash;26.","DOI":"10.1053\/gast.2002.34245"},{"key":"59","doi-asserted-by":"crossref","unstructured":"59. Berthoud HR, Kressel M, Raybould HE, Neuhuber WL. Vagal sensors in the rat duodenal mucosa: distribution and structure as revealed by in vivo DiI-tracing. Anat Embryol (Berl). 1995; 191(3): 203&ndash;12.","DOI":"10.1007\/BF00187819"},{"key":"60","doi-asserted-by":"crossref","unstructured":"60. Tanaka T, Mizumoto A, Mochiki E, Haga N, Suzuki H, Itoh Z. Relationship between intraduodenal 5-hydroxytryptamine release and interdigestive contractions in dogs. J Smooth Muscle Res. 2004; 40(3): 75&ndash;84.","DOI":"10.1540\/jsmr.40.75"},{"key":"61","unstructured":"61. Kellum JM, Maxwell RJ, Potter J, Kummerle JF: Motilin&rsquo;s induction of phasic contractility in canine jejunum is mediated by the luminal release of serotonin. Surgery. 1986; 100(2): 445&ndash;53."},{"key":"62","doi-asserted-by":"crossref","unstructured":"62. Tougas G, Allescher HD, Dent J, Daniel EE. Sensory nerves of the intestines: role in control of pyloric region of dogs. Adv Exp Med Biol. 1991; 298: 199&ndash;211.","DOI":"10.1007\/978-1-4899-0744-8_18"},{"key":"63","doi-asserted-by":"crossref","unstructured":"63. Chen MH, Joffe SN, Magee DF, Murphy RF, Naruse S. Cyclic changes of plasma pancreatic polypeptide and pancreatic secretion in fasting dogs. J Physiol. 1983; 341: 453&ndash;61.","DOI":"10.1113\/jphysiol.1983.sp014816"},{"key":"64","doi-asserted-by":"crossref","unstructured":"64. DiMagno EP, Hendricks JC, Go VL, Dozois RR. Relationships among canine fasting pancreatic and biliary secretions, pancreatic duct pressure, and duodenal phase III motor activity&mdash;Boldyreff revisited. Dig Dis Sci 1979; 24(9): 689&ndash;93.","DOI":"10.1007\/BF01314466"},{"key":"65","doi-asserted-by":"crossref","unstructured":"65. Takahashi T: Mechanism of interdigestive migrating motor complex. J Neurogastroenterol Motil. 2012; 18(3): 246&ndash;57.","DOI":"10.5056\/jnm.2012.18.3.246"},{"key":"66","doi-asserted-by":"crossref","unstructured":"66. Monnikes H, Tebbe JJ, Hildebrandt M, Arck P, Osmanoglou E, Rose M, Klapp B, Wiedenmann B, Heymann-Monnikes I. Role of stress in functional gastrointestinal disorders. Evidence for stress-induced alterations in gastrointestinal motility and sensitivity. Dig Dis. 2001; 19(3): 201&ndash;11.","DOI":"10.1159\/000050681"},{"key":"67","doi-asserted-by":"crossref","unstructured":"67. Feinle-Bisset C, Andrews JM. Treatment of Functional Dyspepsia. 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Conditioned emotional response in rats enhances colonic motility through the central release of corticotropin-releasing factor. Gastroenterology. 1991; 100(4): 964&ndash;70.","DOI":"10.1016\/0016-5085(91)90270-U"},{"key":"71","doi-asserted-by":"crossref","unstructured":"71. Tache Y, Martinez V, Wang L, Million M. CRF1 receptor signaling pathways are involved in stress-related alterations of colonic function and viscerosensitivity: implications for irritable bowel syndrome. Br J Pharmacol. 2004; 141(8): 1321&ndash;30.","DOI":"10.1038\/sj.bjp.0705760"},{"key":"72","doi-asserted-by":"crossref","unstructured":"72. Martinez V, Wang L, Rivier J, Grigoriadis D, Tache Y. Central CRF, urocortins and stress increase colonic transit via CRF1 receptors while activation of CRF2 receptors delays gastric transit in mice. J Physiol. 2004; 556(Pt 1): 221&ndash;34.","DOI":"10.1113\/jphysiol.2003.059659"},{"key":"73","doi-asserted-by":"crossref","unstructured":"73. Nakade Y, Tsuchida D, Fukuda H, Iwa M, Pappas TN, Takahashi T. Restraint stress delays solid gastric emptying via a central CRF and peripheral sympathetic neuron in rats. Am J Physiol Regul Integr Comp Physiol. 2005; 288(2): R427&ndash;32.","DOI":"10.1152\/ajpregu.00499.2004"},{"key":"74","doi-asserted-by":"crossref","unstructured":"74. Tache Y, Maeda-Hagiwara M, Turkelson CM. Central nervous system action of corticotropin-releasing factor to inhibit gastric emptying in rats. Am J Physiol. 1987; 253(2 Pt 1): G241&ndash;5.","DOI":"10.1152\/ajpgi.1987.253.2.G241"},{"key":"75","doi-asserted-by":"crossref","unstructured":"75. Broccardo M, Improta G. Pituitary-adrenal and vagus modulation of sauvagine- and CRF-induced inhibition of gastric emptying in rats. Eur J Pharmacol. 1990; 182(3): 357&ndash;62.","DOI":"10.1016\/0014-2999(90)90294-G"},{"key":"76","doi-asserted-by":"crossref","unstructured":"76. Lenz HJ, Burlage M, Raedler A, Greten H. Central nervous system effects of corticotropin-releasing factor on gastrointestinal transit in the rat. Gastroenterology. 1988; 94(3): 598&ndash;602.","DOI":"10.1016\/0016-5085(88)90229-6"},{"key":"77","doi-asserted-by":"crossref","unstructured":"77. Gue M, Bueno L. Diazepam and muscimol blockade of the gastrointestinal motor disturbances induced by acoustic stress in dogs. Eur J Pharmacol. 1986; 131(1): 123&ndash;7.","DOI":"10.1016\/0014-2999(86)90525-X"},{"key":"78","doi-asserted-by":"crossref","unstructured":"78. Gue M, Fioramonti J, Frexinos J, Alvinerie M, Bueno L. Influence of acoustic stress by noise on gastrointestinal motility in dogs. Dig Dis Sci. 1987; 32(12): 1411&ndash;7.","DOI":"10.1007\/BF01296668"},{"key":"79","doi-asserted-by":"crossref","unstructured":"79. Gue M, Honde C, Pascaud X, Junien JL, Alvinerie M, Bueno L. CNS blockade of acoustic stress-induced gastric motor inhibition by kappa-opiate agonists in dogs. Am J Physiol. 1988; 254(6 Pt 1): G802&ndash;7.","DOI":"10.1152\/ajpgi.1988.254.6.G802"},{"key":"80","doi-asserted-by":"crossref","unstructured":"80. Taniguchi H, Imai K, Ludwig K, Takahashi T. Effects of acupuncture on stress-induced gastrointestinal dysmotility in conscious dogs. Medical Acupuncture. 2012; 24(1): 43&ndash;9.","DOI":"10.1089\/acu.2011.0832"},{"key":"81","doi-asserted-by":"crossref","unstructured":"81. Vantrappen G, Janssens J, Hellemans J, Ghoos Y. The interdigestive motor complex of normal subjects and patients with bacterial overgrowth of the small intestine. J Clin Invest. 1977; 59(6): 1158&ndash;66.","DOI":"10.1172\/JCI108740"},{"key":"82","doi-asserted-by":"crossref","unstructured":"82. Testoni PA, Bagnolo F, Bologna P, Colombo E, Bonassi U, Lella F, Buizza M. Higher prevalence of Helicobacter pylori infection in dyspeptic patients who do not have gastric phase III of the migrating motor complex. Scand J Gastroenterol. 1996; 31(11): 1063&ndash;8.","DOI":"10.3109\/00365529609036888"},{"key":"83","doi-asserted-by":"crossref","unstructured":"83. Testoni PA, Bagnolo F. In dyspeptic patients without gastric phase III of the migrating motor complex, Helicobacter pylori eradication produces no short-term changes in interdigestive motility pattern. Scand J Gastroenterol. 2000; 35(8): 808&ndash;13.","DOI":"10.1080\/003655200750023165"},{"key":"84","doi-asserted-by":"crossref","unstructured":"84. Tack J, Bisschops R, Sarnelli G. Pathophysiology and Treatment of Functional Dyspepsia. Gastroenterology. 2004; 127: 1239&ndash;55.","DOI":"10.1053\/j.gastro.2004.05.030"},{"key":"85","doi-asserted-by":"crossref","unstructured":"85. Quigley EM, Donovan JP, Lane MJ, Gallagher TF. Antroduodenal manometry. Usefulness and limitations as an outpatient study. Dig Dis Sci. 1992; 37(1): 20&ndash;8.","DOI":"10.1007\/BF01308337"},{"key":"86","unstructured":"86. Gu C, Ke M, Wang Z. Temporal and spatial relationship of pylorus to antroduodenal motility in functional dyspepsia. Chin Med J (Engl) 1998; 111(10): 906&ndash;9."},{"key":"87","unstructured":"87. Kusano M, Sekiguchi T, Kawamura O, Kikuchi K, Miyazaki M, Tsunoda T, Horikoshi T, Mori M. Further classification of dysmotility-like dyspepsia by interdigestive gastroduodenal manometry and plasma motilin level. Am J Gastroenterol. 1997; 92(3): 481&ndash;4."},{"key":"88","doi-asserted-by":"crossref","unstructured":"88. Kusano M, Sekiguchi T, Kawamura O, Kikuchi K, Nakamura K, Mori M. Disturbed initiation of gastric interdigestive migrating complexes despite high plasma motilin levels in patients with low gastric pH. Dig Dis Sci. 1998; 43(8): 1697&ndash;700.","DOI":"10.1023\/A:1018815215724"},{"key":"89","doi-asserted-by":"crossref","unstructured":"89. Greydanus MP, Vassallo M, Camilleri M, Nelson DK, Hanson RB, Thomforde GM. Neurohormonal factors in functional dyspepsia: insights on pathophysiological mechanisms. Gastroenterology. 1991; 100(5 Pt 1): 1311&ndash;8.","DOI":"10.1016\/0016-5085(91)70018-S"},{"key":"90","doi-asserted-by":"crossref","unstructured":"90. Holtmann G, Goebell H, Jockenhoevel F, Talley NJ. Altered vagal and intestinal mechanosensory function in chronic unexplained dyspepsia. 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