{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T09:46:23Z","timestamp":1784972783268,"version":"3.55.0"},"reference-count":20,"publisher":"Japan Society of Smooth Muscle Research","issue":"0","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Smooth Muscle Res","J. Smooth Muscle Res."],"published-print":{"date-parts":[[2014]]},"DOI":"10.1540\/jsmr.50.8","type":"journal-article","created":{"date-parts":[[2014,4,25]],"date-time":"2014-04-25T23:09:10Z","timestamp":1398467350000},"page":"8-17","source":"Crossref","is-referenced-by-count":24,"title":["Pathological function of Ca<sup>2+<\/sup>-sensing receptor in pulmonary arterial hypertension"],"prefix":"10.1540","volume":"50","author":[{"given":"Aya","family":"Yamamura","sequence":"first","affiliation":[{"name":"School of Pharmacy, Kinjo Gakuin University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"435","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Rich S, Dantzker DR, Ayres SM, Bergofsky EH, Brundage BH, Detre KM, Fishman AP, Goldring RM, Groves BM, Koerner SK, Levy PC, Reid LM, Vreim CE, Williams GW. Primary pulmonary hypertension. A national prospective study. Ann Intern Med. 1987; 107(2): 216–23.","DOI":"10.7326\/0003-4819-107-2-216"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Badesch DB, Raskob GE, Elliott CG, Krichman AM, Farber HW, Frost AE, Barst RJ, Benza RL, Liou TG, Turner M, Giles S, Feldkircher K, Miller DP, McGoon MD. Pulmonary arterial hypertension: baseline characteristics from the REVEAL Registry. Chest. 2010; 137(2): 376–87.","DOI":"10.1378\/chest.09-1140"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Simonneau G, Robbins IM, Beghetti M, Channick RN, Delcroix M, Denton CP, Elliott CG, Gaine SP, Gladwin MT, Jing ZC, Krowka MJ, Langleben D, Nakanishi N, Souza R. Updated clinical classification of pulmonary hypertension. J Am Coll Cardiol. 2009; 54(1 Suppl): S43–54.","DOI":"10.1016\/j.jacc.2009.04.012"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Montani D, Günther S, Dorfmüller P, Perros F, Girerd B, Garcia G, Jaïs X, Savale L, Artaud-Macari E, Price LC, Humbert M, Simonneau G, Sitbon O. Pulmonary arterial hypertension. Orphanet J Rare Dis. 2013; 8(1): 97.","DOI":"10.1186\/1750-1172-8-97"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Yu Y, Fantozzi I, Remillard CV, Landsberg JW, Kunichika N, Platoshyn O, Tigno DD, Thistlethwaite PA, Rubin LJ, Yuan JX. Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension. Proc Natl Acad Sci USA. 2004; 101(38): 13861–6.","DOI":"10.1073\/pnas.0405908101"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Zhang S, Patel HH, Murray F, Remillard CV, Schach C, Thistlethwaite PA, Insel PA, Yuan JX. Pulmonary artery smooth muscle cells from normal subjects and IPAH patients show divergent cAMP-mediated effects on TRPC expression and capacitative Ca2+<\/sup> entry. Am J Physiol Lung Cell Mol Physiol. 2007; 292(5): L1202–10.","DOI":"10.1152\/ajplung.00214.2006"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Song MY, Makino A, Yuan JX. STIM2 contributes to enhanced store-operated Ca2+<\/sup> entry in pulmonary artery smooth muscle cells from patients with idiopathic pulmonary arterial hypertension. Pulm Circ. 2011; 1(1): 84–94.","DOI":"10.4103\/2045-8932.78106"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Morrell NW, Adnot S, Archer SL, Dupuis J, Jones PL, MacLean MR, McMurtry IF, Stenmark KR, Thistlethwaite PA, Weissmann N, Yuan JX, Weir EK. Cellular and molecular basis of pulmonary arterial hypertension. J Am Coll Cardiol. 2009; 54(1 Suppl): S20–31.","DOI":"10.1016\/j.jacc.2009.04.018"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Yamamura A, Yamamura H, Zeifman A, Yuan JX. Activity of Ca2+<\/sup>-activated Cl–<\/sup> channels contributes to regulating receptor- and store-operated Ca2+<\/sup> entry in human pulmonary artery smooth muscle cells. Pulm Circ. 2011; 1(2): 269–79.","DOI":"10.4103\/2045-8932.83447"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Ko EA, Wan J, Yamamura A, Zimnicka AM, Yamamura H, Yoo HY, Tang H, Smith KA, Sundivakkam PC, Zeifman A, Ayon RJ, Makino A, Yuan JX. Functional characterization of voltage-dependent Ca2+<\/sup> channels in mouse pulmonary arterial smooth muscle cells: divergent effect of ROS. Am J Physiol Cell Physiol. 2013; 304(11): C1042–52.","DOI":"10.1152\/ajpcell.00304.2012"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Wan J, Yamamura A, Zimnicka AM, Voiriot G, Smith KA, Tang H, Ayon RJ, Choudhury MS, Ko EA, Wang J, Wang C, Makino A, Yuan JX. Chronic hypoxia selectively enhances L- and T-type voltage-dependent Ca2+<\/sup> channel activity in pulmonary artery by upregulating Cav<\/sub>1.2 and Cav<\/sub>3.2. Am J Physiol Lung Cell Mol Physiol. 2013; 305(2): L154–64.","DOI":"10.1152\/ajplung.00313.2012"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Yamamura A, Guo Q, Yamamura H, Zimnicka AM, Pohl NM, Smith KA, Fernandez RA, Zeifman A, Makino A, Dong H, Yuan JX. Enhanced Ca2+<\/sup>-sensing receptor function in idiopathic pulmonary arterial hypertension. Circ Res. 2012; 111(4): 469–81.","DOI":"10.1161\/CIRCRESAHA.112.266361"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Brown EM, Gamba G, Riccardi D, Lombardi M, Butters R, Kifor O, Sun A, Hediger MA, Lytton J, Hebert SC. Cloning and characterization of an extracellular Ca2+<\/sup>-sensing receptor from bovine parathyroid. Nature. 1993; 366(6455): 575–80.","DOI":"10.1038\/366575a0"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Bräuner-Osborne H, Wellendorph P, Jensen AA. Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors. Curr Drug Targets. 2007; 8(1): 169–84.","DOI":"10.2174\/138945007779315614"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Urwyler S. Allosteric modulation of family C G-protein-coupled receptors: from molecular insights to therapeutic perspectives. Pharmacol Rev. 2011; 63(1): 59–126.","DOI":"10.1124\/pr.109.002501"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Brown EM. Clinical lessons from the calcium-sensing receptor. Nat Clin Pract Endocrinol Metab. 2007; 3(2): 122–33.","DOI":"10.1038\/ncpendmet0388"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Magno AL, Ward BK, Ratajczak T. The calcium-sensing receptor: a molecular perspective. Endocr Rev. 2011; 32(1): 3–30.","DOI":"10.1210\/er.2009-0043"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Hofer AM, Brown EM. Extracellular calcium sensing and signaling. Nat Rev Mol Cell Biol. 2003; 4(7): 530–8.","DOI":"10.1038\/nrm1154"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Yamamura A, Yamamura H, Guo Q, Zimnicka AM, Wan J, Ko EA, Smith KA, Pohl NM, Song S, Zeifman A, Makino A, Yuan JX. Dihydropyridine Ca2+<\/sup> channel blockers increase cytosolic [Ca2+<\/sup>] by activating Ca2+<\/sup>-sensing receptors in pulmonary arterial smooth muscle cells. Circ Res. 2013; 112(4): 640–50.","DOI":"10.1161\/CIRCRESAHA.113.300897"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Guo Q, Huang JA, Yamamura A, Yamamura H, Zimnicka AM, Fernandez R, Yuan JX. Inhibition of the Ca2+<\/sup>-sensing receptor rescues pulmonary hypertension in rats and mice. Hypertens Res. 2014; 37(2): 116–24.","DOI":"10.1038\/hr.2013.129"}],"container-title":["Journal of Smooth Muscle Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jsmr\/50\/0\/50_8\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T15:22:30Z","timestamp":1746199350000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jsmr\/50\/0\/50_8\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":20,"journal-issue":{"issue":"0","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.1540\/jsmr.50.8","relation":{},"ISSN":["0916-8737","1884-8796"],"issn-type":[{"value":"0916-8737","type":"print"},{"value":"1884-8796","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}