{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T04:22:31Z","timestamp":1748406151644,"version":"3.41.0"},"reference-count":33,"publisher":"Japan Society of Smooth Muscle Research","issue":"0","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Smooth Muscle Res.","J Smooth Muscle Res"],"published-print":{"date-parts":[[2015]]},"DOI":"10.1540\/jsmr.51.10","type":"journal-article","created":{"date-parts":[[2015,5,21]],"date-time":"2015-05-21T22:08:22Z","timestamp":1432246102000},"page":"10-21","source":"Crossref","is-referenced-by-count":2,"title":["Force-inhibiting effect of Ser\/Thr protein phosphatase 2A inhibitors on bovine ciliary muscle"],"prefix":"10.1540","volume":"51","author":[{"given":"Minori","family":"Ishida","sequence":"first","affiliation":[{"name":"Department of Physiology, Asahikawa Medical University, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosuke","family":"Takeya","sequence":"additional","affiliation":[{"name":"Department of Physiology, Asahikawa Medical University, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoi","family":"Miyazu","sequence":"additional","affiliation":[{"name":"Department of Physiology, Asahikawa Medical University, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akitoshi","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Physiology, Asahikawa Medical University, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Takai","sequence":"additional","affiliation":[{"name":"Department of Physiology, Asahikawa Medical University, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"435","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Suzuki R. Neuronal influence on the mechanical activity of the ciliary muscle. Br J Pharmacol. 1983 Mar; 78(3): 591&ndash;7. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2044737\/.","DOI":"10.1111\/j.1476-5381.1983.tb08819.x"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Kamikawatoko S, Tokoro T, Ishida A, Masuda H, Hamasaki H, Sato J, Azuma H. Nitric oxide relaxes bovine ciliary muscle contracted by carbachol through elevation of cyclic GMP. Exp Eye Res. 1998 Jan; 66(1): 1&ndash;7. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9533825.","DOI":"10.1006\/exer.1997.0408"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Yasui F, Miyazu M, Yoshida A, Naruse K, Takai A. Examination of signalling pathways involved in muscarinic responses in bovine ciliary muscle using YM-254890, an inhibitor of the G<sub>q\/11<\/sub> protein. Br J Pharmacol. 2008 Jun; 154(4): 890&ndash;900. Available from: http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=2439854&amp;tool=pmcentrez&amp;rendertype=abstract.","DOI":"10.1038\/bjp.2008.140"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Masuda H, Goto M, Tamaoki S, Kamikawatoko S, Tokoro T, Azuma H. M<sub>3<\/sub>-type muscarinic receptors predominantly mediate neurogenic quick contraction of bovine ciliary muscle. Gen Pharmacol. 1998 Apr; 30(4): 579&ndash;84. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9522179.","DOI":"10.1016\/S0306-3623(97)00312-1"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Takai Y, Awaya S, Takai A. Activation of non-selective cation conductance by carbachol in freshly isolated bovine ciliary muscle cells. Pfl&uuml;gers Arch. 1997 Apr; 433(6): 705&ndash;12. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9049160","DOI":"10.1007\/s004240050335"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Takai Y, Sugawara R, Ohinata H, Takai A. Two types of non-selective cation channel opened by muscarinic stimulation with carbachol in bovine ciliary muscle cells. J Physiol. 2004 Sep 15; 559(Pt 3): 899&ndash;922. Available from: http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=1665188&amp;tool=pmcentrez&amp;rendertype=abstract","DOI":"10.1113\/jphysiol.2004.065607"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Sugawara R, Takai Y, Miyazu M, Ohinata H, Yoshida A, Takai A. Agonist and antagonist sensitivity of non-selective cation channel currents evoked by muscarinic receptor stimulation in bovine ciliary muscle cells. Auton Autacoid Pharmacol. 2006 Jul; 26(3): 285&ndash;92. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16879494.","DOI":"10.1111\/j.1474-8673.2006.00347.x"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Kageyama M, Shirasawa E. L-type voltage-dependent Ca<sup>2+<\/sup> and ATP-sensitive K<sup>+<\/sup> channels are not involved in the regulation of bovine ciliary muscle contractility. J Ocul Pharmacol Ther. 1995 Jan; 11(4): 553&ndash;63. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8574819.","DOI":"10.1089\/jop.1995.11.553"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Shibata S, Ishida Y, Kitano H, Ohizumi Y, Habon J, Tsukitani Y, Kikuchi H. Contractile effects of okadaic acid, a novel ionophore-like substance from black sponge, on isolated smooth muscles under the condition of Ca deficiency. J Pharmacol Exp Ther. 1982 Oct; 223(1): 135&ndash;43. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/6214623.","DOI":"10.1016\/S0022-3565(25)33303-3"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Ozaki H, Ishihara H, Kohama K, Nonomura Y, Shibata S, Karaki H. Calcium-independent phosphorylation of smooth muscle myosin light chain by okadaic acid isolated from black sponge (<i>Halichondria okadai<\/i>). J Pharmacol Exp Ther. 1987 Dec; 243(3): 1167&ndash;73. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/2826758.","DOI":"10.1016\/S0022-3565(25)39284-0"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Ozaki H, Kohama K, Nonomura Y, Shibata S, Karaki H. Direct activation by okadaic acid of the contractile elements in the smooth muscle of guinea-pig taenia coli. Naunyn-Schmiedeberg&rsquo;s Arch Pharmacol. 1987 Mar; 335(3): 356&ndash;8. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/3035385.","DOI":"10.1007\/BF00172811"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Takai A, Bialojan C, Troschka M, R&uuml;egg JC. Smooth muscle myosin phosphatase inhibition and force enhancement by black sponge toxin. FEBS Lett. 1987 Jun 8; 217(1): 81&ndash;4. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/3036577.","DOI":"10.1016\/0014-5793(87)81247-4"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Bialojan C, R&uuml;egg JC, Takai A. Effects of okadaic acid on isometric tension and myosin phosphorylation of chemically skinned guinea-pig taenia coli. J Physiol. 1988 Apr; 398: 81&ndash;95. Available from: http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=1191760&amp;tool=pmcentrez&amp;rendertype=abstract.","DOI":"10.1113\/jphysiol.1988.sp017030"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Hirano K, Kanaide H, Nakamura M. Effects of okadaic acid on cytosolic calcium concentrations and on contractions of the porcine coronary artery. Br J Pharmacol. 1989 Dec; 98(4): 1261&ndash;6. Available from: http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=1854834&amp;tool=pmcentrez&amp;rendertype=abstract.","DOI":"10.1111\/j.1476-5381.1989.tb12672.x"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Karaki H, Mitsui M, Nagase H, Ozaki H, Shibata S, Uemura D. Inhibitory effect of a toxin okadaic acid, isolated from the black sponge on smooth muscle and platelets. Br J Pharmacol. 1989 Oct; 98(2): 590&ndash;6. Available from: http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=1854712&amp;tool=pmcentrez&amp;rendertype=abstract.","DOI":"10.1111\/j.1476-5381.1989.tb12633.x"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Ashizawa N, Kobayashi F, Tanaka Y, Nakayama K. Relaxing action of okadaic acid, a black sponge toxin on the arterial smooth muscle. Biochem Biophys Res Commun. 1989 Aug 15; 162(3): 971&ndash;6. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/2764949.","DOI":"10.1016\/0006-291X(89)90768-7"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Shibata S, Satake N, Morikawa M, Kown SC, Karaki H, Kurahashi K, Sawada T, Kodama I. The inhibitory action of okadaic acid on mechanical responses in guinea-pig vas deferens. Eur J Pharmacol. 1991 Jan 25; 193(1): 1&ndash;7. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/1710986.","DOI":"10.1016\/0014-2999(91)90192-S"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Wang XL, Akhtar RA, Abdel-Latif AA. Studies on the properties of myo-inositol-1,4,5-trisphosphate 5-phosphatase and myo-inositol monophosphatase in bovine iris sphincter smooth muscle: effects of okadaic acid and protein phosphorylation. Biochim Biophys Acta. 1994 May 26; 1222(1): 27&ndash;36. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8186262.","DOI":"10.1016\/0167-4889(94)90021-3"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Takai A, Sasaki K, Nagai H, Mieskes G, Isobe M, Isono K, Yasumoto T. Inhibition of specific binding of okadaic acid to protein phosphatase 2A by microcystin-LR, calyculin-A and tautomycin: method of analysis of interactions of tight-binding ligands with target protein. Biochem J. 1995 Mar 15; 306 (Pt 3): 657&ndash;65. Available from: http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=1136572&amp;tool=pmcentrez&amp;rendertype=abstract.","DOI":"10.1042\/bj3060657"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Watanabe M, Nakano M. Force-inhibiting effect of okadaic acid on skinned rat uterus permeabilized with &alpha;-toxin. Pfl&uuml;gers Arch. 1995 Sep; 430(5): 754&ndash;6. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/7478929.","DOI":"10.1007\/BF00386172"},{"key":"21","unstructured":"21. Uehata M, Ishizaki T, Satoh H, Ono T, Kawahara T, Morishita T, Tamakawa H, Yamagami K, Inui J, Maekawa M, Narumiya S. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature. 1997 Oct 30; 389(6654): 990&ndash;4. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9353125."},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Somlyo AP, Somlyo AV. Ca<sup>2+<\/sup> sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase. Physiol Rev. 2003 Oct; 83(4): 1325&ndash;58. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/14506307.","DOI":"10.1152\/physrev.00023.2003"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Gunst SJ, Zhang W. Actin cytoskeletal dynamics in smooth muscle: a new paradigm for the regulation of smooth muscle contraction. Am J Physiol Cell Physiol. 2008 Sep; 295(3): C576&ndash;87. Available from: http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=2544441&amp;tool=pmcentrez&amp;rendertype=abstract.","DOI":"10.1152\/ajpcell.00253.2008"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Walsh AH, Cheng A, Honkanen RE. Fostriecin, an antitumor antibiotic with inhibitory activity against serine\/threonine protein phosphatases types 1 (PP1) and 2A (PP2A), is highly selective for PP2A. FEBS Lett. 1997 Oct; 416(3): 230&ndash;4. Available from: http:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014579397012106.","DOI":"10.1016\/S0014-5793(97)01210-6"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Wada S, Usami I, Umezawa Y, Inoue H, Ohba S, Someno T, Kawada M, Ikeda D. Rubratoxin A specifically and potently inhibits protein phosphatase 2A and suppresses cancer metastasis. Cancer Sci. 2010 Mar; 101(3): 743&ndash;50. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20028386.","DOI":"10.1111\/j.1349-7006.2009.01438.x"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Obara K, Ito Y, Shimada H, Nakayama K. The relaxant effect of okadaic acid on canine basilar artery involves activation of PKC&alpha; and phosphorylation of the myosin light chain at Thr-9. Eur J Pharmacol. 2008 Nov 19; 598(1&ndash;3): 87&ndash;93. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18835557.","DOI":"10.1016\/j.ejphar.2008.09.023"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Obara K, Mitate A, Nozawa K, Watanabe M, Ito Y, Nakayama K. Interactive role of protein phosphatase 2A and protein kinase C&alpha; in the stretch-induced triphosphorylation of myosin light chain in canine cerebral artery. J Vasc Res. 2010 Jan; 47(2): 115&ndash;27. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19729958.","DOI":"10.1159\/000235966"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Ishihara H, Ozaki H, Sato K, Hori M, Karaki H, Watabe S, Kato Y, Fusetani N, Hashimoto K, Uemura D. Calcium-independent activation of contractile apparatus in smooth muscle by calyculin-A. J Pharmacol Exp Ther. 1989 Jul; 250(1): 388&ndash;96. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/2545866.","DOI":"10.1016\/S0022-3565(25)21393-3"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Hori M, Magae J, Han YG, Hartshorne DJ, Karaki H. A novel protein phosphatase inhibitor, tautomycin. Effect on smooth muscle. FEBS Lett. 1991 Jul 8; 285(1): 145&ndash;8. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/1648511.","DOI":"10.1016\/0014-5793(91)80745-O"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Fukiage C, Mizutani K, Kawamoto Y, Azuma M, Shearer TR. Involvement of phosphorylation of myosin phosphatase by ROCK in trabecular meshwork and ciliary muscle contraction. Biochem Biophys Res Commun. 2001 Oct 26; 288(2): 296&ndash;300. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11606042.","DOI":"10.1006\/bbrc.2001.5751"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Watanabe M, Takano-Ohmuro H. Extensive skinning of cell membrane diminishes the force-inhibiting effect of okadaic acid on smooth muscles of guinea pig hepatic portal vein. Jpn J Physiol. 2002 Apr; 52(2): 141&ndash;7. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12139772.","DOI":"10.2170\/jjphysiol.52.141"},{"key":"32","unstructured":"32. Thieme H, Nass JU, Nuskovski M, Bechrakis NE, Stumpff F, Strauss O, Wiederholt M. The effects of protein kinase C on trabecular meshwork and ciliary muscle contractility. Invest Ophthalmol Vis Sci. 1999 Dec; 40(13): 3254&ndash;61. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10586950."},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Harrison S, Spina D, Page CP. The effect of okadaic acid on non-adrenergic non-cholinergic contraction in guinea-pig isolated bronchus. Br J Pharmacol. 1997 May; 121(2): 181&ndash;6. Available from: http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=1564673&amp;tool=pmcentrez&amp;rendertype=abstract.","DOI":"10.1038\/sj.bjp.0701114"}],"container-title":["Journal of Smooth Muscle Research"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T02:09:16Z","timestamp":1748398156000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jsmr\/51\/0\/51_10\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":33,"journal-issue":{"issue":"0","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.1540\/jsmr.51.10","relation":{},"ISSN":["0916-8737","1884-8796"],"issn-type":[{"type":"print","value":"0916-8737"},{"type":"electronic","value":"1884-8796"}],"subject":[],"published":{"date-parts":[[2015]]}}}