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Busse, WW, Lemanske, RFJr . Asthma. N Engl J Med. 2001; 344(5): 350\u201362.","DOI":"10.1056\/NEJM200102013440507"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Girodet, PO, Ozier, A, Trian, T, Begueret, H, Ousova, O, Vernejoux, JM, Chanez, P, Marthan, R, Berger, P, Tunon de Lara, JM. Mast cell adhesion to bronchial smooth muscle in asthma specifically depends on CD51 and CD44 variant 6. Allergy. 2010; 65(8): 1004\u201312.","DOI":"10.1111\/j.1398-9995.2009.02308.x"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Denis, D, Fayon, MJ, Berger, P, Molimard, M, De Lara, MT, Roux, E, Marthan, R. Prolonged moderate hyperoxia induces hyperresponsiveness and airway inflammation in newborn rats. Pediatr Res. 2001; 50(4): 515\u20139.","DOI":"10.1203\/00006450-200110000-00015"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Cockcroft, DW, Killian, DN, Mellon, JJ, Hargreave, FE. Bronchial reactivity to inhaled histamine: a method and clinical survey. Clin Allergy. 1977; 7(3): 235\u201343.","DOI":"10.1111\/j.1365-2222.1977.tb01448.x"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Juniper, EF, Frith, PA, Hargreave, FE. Airway responsiveness to histamine and methacholine: relationship to minimum treatment to control symptoms of asthma. Thorax. 1981; 36(8): 575\u20139.","DOI":"10.1136\/thx.36.8.575"},{"key":"6","unstructured":"6. Peat, JK, Woolcock, AJ, Cullen, K. Rate of decline of lung function in subjects with asthma. Eur J Respir Dis. 1987; 70(3): 171\u20139."},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. James, AL, Par\u00e9, PD, Hogg, JC. The mechanics of airway narrowing in asthma. Am Rev Respir Dis. 1989; 139(1): 242\u20136.","DOI":"10.1164\/ajrccm\/139.1.242"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Misawa, M, Chiba, Y. Repeated antigenic challenge-induced airway hyperresponsiveness and airway inflammation in actively sensitized rats. Jpn J Pharmacol. 1993; 61(1): 41\u201350.","DOI":"10.1254\/jjp.61.41"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Chiba, Y, Ueno, A, Shinozaki, K, Takeyama, H, Nakazawa, S, Sakai, H, Misawa, M. Involvement of RhoA-mediated Ca2+ sensitization in antigen-induced bronchial smooth muscle hyperresponsiveness in mice. Respir Res. 2005; 6: 4.","DOI":"10.1186\/1465-9921-6-4"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Kato, Y, Manabe, T, Tanaka, Y, Mochizuki, H. Effect of an orally active Th1\/Th2 balance modulator, M50367, on IgE production, eosinophilia, and airway hyperresponsiveness in mice. J Immunol. 1999; 162(12): 7470\u20139.","DOI":"10.4049\/jimmunol.162.12.7470"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Seow, CY, Schellenberg, RR, Par\u00e9, PD. Structural and functional changes in the airway smooth muscle of asthmatic subjects. Am J Respir Crit Care Med. 1998; 158(5 Pt 3): S179\u201386.","DOI":"10.1164\/ajrccm.158.supplement_2.13tac160"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Chiba, Y, Misawa, M. Characteristics of muscarinic cholinoceptors in airways of antigen-induced airway hyperresponsive rats. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1995; 111(3): 351\u20137.","DOI":"10.1016\/0742-8413(95)00061-5"},{"key":"13","unstructured":"13. Chiba, Y, Sakai, H, Suenaga, H, Kamata, K, Misawa, M. Enhanced Ca2+ sensitization of the bronchial smooth muscle contraction in antigen-induced airway hyperresponsive rats. Res Commun Mol Pathol Pharmacol. 1999; 106(1-2): 77\u201385."},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Chiba, Y, Misawa, M. Alteration in Ca2+ availability involved in antigen-induced airway hyperresponsiveness in rats. Eur J Pharmacol. 1995; 278(1): 79\u201382.","DOI":"10.1016\/0014-2999(95)00132-5"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Chiba, Y, Takada, Y, Miyamoto, S, MitsuiSaito, M, Karaki, H, Misawa, M. Augmented acetylcholine-induced, Rho-mediated Ca2+ sensitization of bronchial smooth muscle contraction in antigen-induced airway hyperresponsive rats. Br J Pharmacol. 1999; 127(3): 597\u2013600.","DOI":"10.1038\/sj.bjp.0702585"},{"key":"16","doi-asserted-by":"publisher","unstructured":"16. Somlyo, AP, Somlyo, AV. Signal transduction and regulation in smooth muscle. Nature. 1994; 372(6503): 231\u20136.","DOI":"10.1038\/372231a0"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Hartshorne, DJ, Ito, M, Erd\u00f6di, F. Role of protein phosphatase type 1 in contractile functions: myosin phosphatase. J Biol Chem. 2004; 279(36): 37211\u20134.","DOI":"10.1074\/jbc.R400018200"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Somlyo, AP, Somlyo, AV. Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase. Physiol Rev. 2003; 83(4): 1325\u201358.","DOI":"10.1152\/physrev.00023.2003"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Noda, M, Yasuda-Fukazawa, C, Moriishi, K, Kato, T, Okuda, T, Kurokawa, K, Takuwa, Y. Involvement of rho in GTP gamma S-induced enhancement of phosphorylation of 20 kDa myosin light chain in vascular smooth muscle cells: inhibition of phosphatase activity. FEBS Lett. 1995; 367(3): 246\u201350.","DOI":"10.1016\/0014-5793(95)00573-R"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Matsui, T, Amano, M, Yamamoto, T, Chihara, K, Nakafuku, M, Ito, M, Nakano, T, Okawa, K, Iwamatsu, A, Kaibuchi, K. Rho-associated kinase, a novel serine\/threonine kinase, as a putative target for small GTP binding protein Rho. EMBO J. 1996; 15(9): 2208\u201316.","DOI":"10.1002\/j.1460-2075.1996.tb00574.x"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Ishizaki, T, Naito, M, Fujisawa, K, Maekawa, M, Watanabe, N, Saito, Y, Narumiya, S. p160ROCK, a Rho-associated coiled-coil forming protein kinase, works downstream of Rho and induces focal adhesions. FEBS Lett. 1997; 404(2-3): 118\u201324.","DOI":"10.1016\/S0014-5793(97)00107-5"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Leung, T, Manser, E, Tan, L, Lim, L. A novel serine\/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranes. J Biol Chem. 1995; 270(49): 29051\u20134.","DOI":"10.1074\/jbc.270.49.29051"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Mur\u00e1nyi, A, Derkach, D, Erdodi, F, Kiss, A, Ito, M, Hartshorne, DJ. Phosphorylation of Thr695 and Thr850 on the myosin phosphatase target subunit: inhibitory effects and occurrence in A7r5 cells. FEBS Lett. 2005; 579(29): 6611\u20135.","DOI":"10.1016\/j.febslet.2005.10.055"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Chiba, Y, Takeyama, H, Sakai, H, Misawa, M. Effects of Y-27632 on acetylcholine-induced contraction of intact and permeabilized intrapulmonary bronchial smooth muscles in rats. Eur J Pharmacol. 2001; 427(1): 77\u201382.","DOI":"10.1016\/S0014-2999(01)01225-0"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Chiba, Y, Sakai, H, Misawa, M. Augmented acetylcholine-induced translocation of RhoA in bronchial smooth muscle from antigen-induced airway hyperresponsive rats. Br J Pharmacol. 2001; 133(6): 886\u201390.","DOI":"10.1038\/sj.bjp.0704137"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Martin, JG, Duguet, A, Eidelman, DH. The contribution of airway smooth muscle to airway narrowing and airway hyperresponsiveness in disease. Eur Respir J. 2000; 16(2): 349\u201354.","DOI":"10.1034\/j.1399-3003.2000.16b25.x"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Schembri, F, Sridhar, S, Perdomo, C, Gustafson, AM, Zhang, X, Ergun, A, Lu, J, Liu, G, Zhang, X, Bowers, J, Vaziri, C, Ott, K, Sensinger, K, Collins, JJ, Brody, JS, Getts, R, Lenburg, ME, Spira, A. MicroRNAs as modulators of smoking-induced gene expression changes in human airway epithelium. Proc Natl Acad Sci USA. 2009; 106(7): 2319\u201324.","DOI":"10.1073\/pnas.0806383106"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Gosens, R, Schaafsma, D, Nelemans, SA, Halayko, AJ. Rho-kinase as a drug target for the treatment of airway hyperrespon-siveness in asthma. Mini Rev Med Chem. 2006; 6(3): 339\u201348.","DOI":"10.2174\/138955706776073402"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Schaafsma, D, Gosens, R, Zaagsma, J, Halayko, AJ, Meurs, H. Rho kinase inhibitors: a novel therapeutical intervention in asthma? Eur J Pharmacol. 2008; 585(2-3): 398\u2013406.","DOI":"10.1016\/j.ejphar.2008.01.056"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Schaafsma, D, Roscioni, SS, Meurs, H, Schmidt, M. Monomeric G-proteins as signal transducers in airway physiology and pathophysiology. Cell Signal. 2008; 20(10): 1705\u201314.","DOI":"10.1016\/j.cellsig.2008.04.012"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Kume, H. RhoA\/Rho-kinase as a therapeutic target in asthma. Curr Med Chem. 2008; 15(27): 2876\u201385.","DOI":"10.2174\/092986708786242831"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Broide, DH, Lotz, M, Cuomo, AJ, Coburn, DA, Federman, EC, Wasserman, SI. Cytokines in symptomatic asthma airways. J Allergy Clin Immunol. 1992; 89(5): 958\u201367.","DOI":"10.1016\/0091-6749(92)90218-Q"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Ying, S, Robinson, DS, Varney, V, Meng, Q, Tsicopoulos, A, Moqbel, R, Durham, SR, Kay, AB, Hamid, Q. TNF alpha mRNA expression in allergic inflammation. Clin Exp Allergy. 1991; 21(6): 745\u201350.","DOI":"10.1111\/j.1365-2222.1991.tb03205.x"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Gosset, P, Tsicopoulos, A, Wallaert, B, Vannimenus, C, Joseph, M, Tonnel, AB, Capron, A. Increased secretion of tumor necrosis factor alpha and interleukin-6 by alveolar macrophages consecutive to the development of the late asthmatic reaction. J Allergy Clin Immunol. 1991; 88(4): 561\u201371.","DOI":"10.1016\/0091-6749(91)90149-I"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Azevedo, I, de Blic, J, Dumarey, CH, Scheinmann, P, Vargaftig, BB, Bachelet, M. Increased spontaneous release of tumour necrosis factor-alpha by alveolar macrophages from wheezy infants. Eur Respir J. 1997; 10(8): 1767\u201373.","DOI":"10.1183\/09031936.97.10081767"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Thomas, PS, Yates, DH, Barnes, PJ. Tumor necrosis factor-alpha increases airway responsiveness and sputum neutrophilia in normal human subjects. Am J Respir Crit Care Med. 1995; 152(1): 76\u201380.","DOI":"10.1164\/ajrccm.152.1.7599866"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Sakai, H, Otogoto, S, Chiba, Y, Abe, K, Misawa, M. Involvement of p42\/44 MAPK and RhoA protein in augmentation of ACh-induced bronchial smooth muscle contraction by TNF-alpha in rats. J Appl Physiol 1985. 2004; 97(6): 2154\u20139.","DOI":"10.1152\/japplphysiol.00752.2003"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Chiba, Y, Arima, J, Sakai, H, Misawa, M. Lovastatin inhibits bronchial hyperresponsiveness by reducing RhoA signaling in rat allergic asthma. Am J Physiol Lung Cell Mol Physiol. 2008; 294(4): L705\u201313.","DOI":"10.1152\/ajplung.00531.2007"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Batra, V, Musani, AI, Hastie, AT, Khurana, S, Carpenter, KA, Zangrilli, JG, Peters, SP. Bronchoalveolar lavage fluid concentrations of transforming growth factor (TGF)-beta1, TGF-beta2, interleukin (IL)-4 and IL-13 after segmental allergen challenge and their effects on alpha-smooth muscle actin and collagen III synthesis by primary human lung fibroblasts. Clin Exp Allergy. 2004; 34(3): 437\u201344.","DOI":"10.1111\/j.1365-2222.2004.01885.x"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Steinke, JW, Borish, L. Th2 cytokines and asthma. Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists. Respir Res. 2001; 2(2): 66\u201370.","DOI":"10.1186\/rr40"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Dabbagh, K, Takeyama, K, Lee, HM, Ueki, IF, Lausier, JA, Nadel, JA. IL-4 induces mucin gene expression and goblet cell metaplasia in vitro and in vivo. J Immunol. 1999; 162(10): 6233\u20137.","DOI":"10.4049\/jimmunol.162.10.6233"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Bryborn, M, Adner, M, Cardell, LO. Interleukin-4 increases murine airway response to kinins, via up-regulation of bradykinin B1-receptors and altered signalling along mitogen-activated protein kinase pathways. Clin Exp Allergy. 2004; 34(8): 1291\u20138.","DOI":"10.1111\/j.1365-2222.2004.02031.x"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Chiba, Y, Sakai, H, Wachi, H, Sugitani, H, Seyama, Y, Misawa, M. Upregulation of rhoA mRNA in bronchial smooth muscle of antigen-induced airway hyperresponsive rats. J Smooth Muscle Res. 2003; 39(6): 221\u20138.","DOI":"10.1540\/jsmr.39.221"},{"key":"44","doi-asserted-by":"publisher","unstructured":"44. Wills-Karp, M, Luyimbazi, J, Xu, X, Schofield, B, Neben, TY, Karp, CL, Donaldson, DD. Interleukin-13: central mediator of allergic asthma. Science. 1998; 282(5397): 2258\u201361.","DOI":"10.1126\/science.282.5397.2258"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45. Gr\u00fcnig, G, Warnock, M, Wakil, AE, Venkayya, R, Brombacher, F, Rennick, DM, Sheppard, D, Mohrs, M, Donaldson, DD, Locksley, RM, Corry, DB. Requirement for IL-13 independently of IL-4 in experimental asthma. Science. 1998; 282(5397): 2261\u20133.","DOI":"10.1126\/science.282.5397.2261"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46. Walter, DM, McIntire, JJ, Berry, G, McKenzie, AN, Donaldson, DD, DeKruyff, RH, Umetsu, DT. Critical role for IL-13 in the development of allergen-induced airway hyperreactivity. J Immunol. 2001; 167(8): 4668\u201375.","DOI":"10.4049\/jimmunol.167.8.4668"},{"key":"47","doi-asserted-by":"publisher","unstructured":"47. Zhu, Z, Zheng, T, Homer, RJ, Kim, YK, Chen, NY, Cohn, L, Hamid, Q, Elias, JA. Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation. Science. 2004; 304(5677): 1678\u201382.","DOI":"10.1126\/science.1095336"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48. Postma, DS, Bleecker, ER, Amelung, PJ, Holroyd, KJ, Xu, J, Panhuysen, CI, Meyers, DA, Levitt, RC. Genetic susceptibility to asthma--bronchial hyperresponsiveness coinherited with a major gene for atopy. N Engl J Med. 1995; 333(14): 894\u2013900.","DOI":"10.1056\/NEJM199510053331402"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49. Palmer, LJ, Daniels, SE, Rye, PJ, Gibson, NA, Tay, GK, Cookson, WO, Goldblatt, J, Burton, PR, LeS\u00f6uef, PN. Linkage of chromosome 5q and 11q gene markers to asthma-associated quantitative traits in Australian children. Am J Respir Crit Care Med. 1998; 158(6): 1825\u201330.","DOI":"10.1164\/ajrccm.158.6.9804037"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50. Bodey, KJ, Semper, AE, Redington, AE, Madden, J, Teran, LM, Holgate, ST, Frew, AJ. Cytokine profiles of BAL T cells and T-cell clones obtained from human asthmatic airways after local allergen challenge. Allergy. 1999; 54(10): 1083\u201393.","DOI":"10.1034\/j.1398-9995.1999.00889.x"},{"key":"51","doi-asserted-by":"crossref","unstructured":"51. Prieto, J, Lensmar, C, Roquet, A, van der Ploeg, I, Gigliotti, D, Eklund, A, Grunewald, J. Increased interleukin-13 mRNA expression in bronchoalveolar lavage cells of atopic patients with mild asthma after repeated low-dose allergen provocations. Respir Med. 2000; 94(8): 806\u201314.","DOI":"10.1053\/rmed.2000.0826"},{"key":"52","doi-asserted-by":"crossref","unstructured":"52. Zhu, Z, Homer, RJ, Wang, Z, Chen, Q, Geba, GP, Wang, J, Zhang, Y, Elias, JA. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest. 1999; 103(6): 779\u201388.","DOI":"10.1172\/JCI5909"},{"key":"53","doi-asserted-by":"crossref","unstructured":"53. Yang, M, Hogan, SP, Henry, PJ, Matthaei, KI, McKenzie, AN, Young, IG, Rothenberg, ME, Foster, PS. Interleukin-13 mediates airways hyperreactivity through the IL-4 receptor-alpha chain and STAT-6 independently of IL-5 and eotaxin. Am J Respir Cell Mol Biol. 2001; 25(4): 522\u201330.","DOI":"10.1165\/ajrcmb.25.4.4620"},{"key":"54","doi-asserted-by":"crossref","unstructured":"54. Chiba, Y, Nakazawa, S, Todoroki, M, Shinozaki, K, Sakai, H, Misawa, M. Interleukin-13 augments bronchial smooth muscle contractility with an up-regulation of RhoA protein. Am J Respir Cell Mol Biol. 2009; 40(2): 159\u201367.","DOI":"10.1165\/rcmb.2008-0162OC"},{"key":"55","doi-asserted-by":"crossref","unstructured":"55. Xu, P, Guo, M, Hay, BA. MicroRNAs and the regulation of cell death. Trends Genet. 2004; 20(12): 617\u201324.","DOI":"10.1016\/j.tig.2004.09.010"},{"key":"56","doi-asserted-by":"crossref","unstructured":"56. Cheng, AM, Byrom, MW, Shelton, J, Ford, LP. Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis. Nucleic Acids Res. 2005; 33(4): 1290\u20137.","DOI":"10.1093\/nar\/gki200"},{"key":"57","doi-asserted-by":"crossref","unstructured":"57. Felli, N, Fontana, L, Pelosi, E, Botta, R, Bonci, D, Facchiano, F, Liuzzi, F, Lulli, V, Morsilli, O, Santoro, S, Valtieri, M, Calin, GA, Liu, CG, Sorrentino, A, Croce, CM, Peschle, C. MicroRNAs 221 and 222 inhibit normal erythropoiesis and erythroleukemic cell growth via kit receptor down-modulation. Proc Natl Acad Sci USA. 2005; 102(50): 18081\u20136.","DOI":"10.1073\/pnas.0506216102"},{"key":"58","doi-asserted-by":"crossref","unstructured":"58. Dresios, J, Aschrafi, A, Owens, GC, Vanderklish, PW, Edelman, GM, Mauro, VP. Cold stress-induced protein Rbm3 binds 60S ribosomal subunits, alters microRNA levels, and enhances global protein synthesis. Proc Natl Acad Sci USA. 2005; 102(6): 1865\u201370.","DOI":"10.1073\/pnas.0409764102"},{"key":"59","doi-asserted-by":"crossref","unstructured":"59. Guo, H, Ingolia, NT, Weissman, JS, Bartel, DP. Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature. 2010; 466(7308): 835\u201340.","DOI":"10.1038\/nature09267"},{"key":"60","doi-asserted-by":"crossref","unstructured":"60. Kang, H, Davis-Dusenbery, BN, Nguyen, PH, Lal, A, Lieberman, J, Van Aelst, L, Lagna, G, Hata, A. Bone morphogenetic protein 4 promotes vascular smooth muscle contractility by activating microRNA-21 (miR-21), which down-regulates expression of family of dedicator of cytokinesis (DOCK) proteins. J Biol Chem. 2012; 287(6): 3976\u201386.","DOI":"10.1074\/jbc.M111.303156"},{"key":"61","doi-asserted-by":"crossref","unstructured":"61. Williams, KC, Renthal, NE, Gerard, RD, Mendelson, CR. The microRNA (miR)-199a\/214 cluster mediates opposing effects of progesterone and estrogen on uterine contractility during pregnancy and labor. Mol Endocrinol. 2012; 26(11): 1857\u201367.","DOI":"10.1210\/me.2012-1199"},{"key":"62","doi-asserted-by":"crossref","unstructured":"62. Car\u00e8, A, Catalucci, D, Felicetti, F, Bonci, D, Addario, A, Gallo, P, Bang, ML, Segnalini, P, Gu, Y, Dalton, ND, Elia, L, Latronico, MV, H\u00f8ydal, M, Autore, C, Russo, MA, Dorn, GW2nd , Ellingsen, O, Ruiz-Lozano, P, Peterson, KL, Croce, CM, Peschle, C, Condorelli, G. MicroRNA-133 controls cardiac hypertrophy. Nat Med. 2007; 13(5): 613\u20138.","DOI":"10.1038\/nm1582"},{"key":"63","doi-asserted-by":"crossref","unstructured":"63. Rehmsmeier, M, Steffen, P, Hochsmann, M, Giegerich, R. Fast and effective prediction of microRNA\/target duplexes. RNA. 2004; 10(10): 1507\u201317.","DOI":"10.1261\/rna.5248604"},{"key":"64","doi-asserted-by":"crossref","unstructured":"64. Chiba, Y, Tanabe, M, Goto, K, Sakai, H, Misawa, M. Down-regulation of miR-133a contributes to up-regulation of Rhoa in bronchial smooth muscle cells. Am J Respir Crit Care Med. 2009; 180(8): 713\u20139.","DOI":"10.1164\/rccm.200903-0325OC"},{"key":"65","doi-asserted-by":"crossref","unstructured":"65. Chiba, Y, Todoroki, M, Nishida, Y, Tanabe, M, Misawa, M. A novel STAT6 inhibitor AS1517499 ameliorates antigen-induced bronchial hypercontractility in mice. Am J Respir Cell Mol Biol. 2009; 41(5): 516\u201324.","DOI":"10.1165\/rcmb.2008-0163OC"},{"key":"66","doi-asserted-by":"crossref","unstructured":"66. Eto, M, Ohmori, T, Suzuki, M, Furuya, K, Morita, F. A novel protein phosphatase-1 inhibitory protein potentiated by protein kinase C. Isolation from porcine aorta media and characterization. J Biochem. 1995; 118(6): 1104\u20137.","DOI":"10.1093\/oxfordjournals.jbchem.a124993"},{"key":"67","doi-asserted-by":"crossref","unstructured":"67. Woodsome, TP, Eto, M, Everett, A, Brautigan, DL, Kitazawa, T. Expression of CPI-17 and myosin phosphatase correlates with Ca(2+) sensitivity of protein kinase C-induced contraction in rabbit smooth muscle. J Physiol. 2001; 535(Pt 2): 553\u201364.","DOI":"10.1111\/j.1469-7793.2001.t01-1-00553.x"},{"key":"68","doi-asserted-by":"crossref","unstructured":"68. Kitazawa, T, Eto, M, Woodsome, TP, Khalequzzaman, M. Phosphorylation of the myosin phosphatase targeting subunit and CPI-17 during Ca2+ sensitization in rabbit smooth muscle. J Physiol. 2003; 546(Pt 3): 879\u201389.","DOI":"10.1113\/jphysiol.2002.029306"},{"key":"69","doi-asserted-by":"crossref","unstructured":"69. Dimopoulos, GJ, Semba, S, Kitazawa, K, Eto, M, Kitazawa, T. Ca2+-dependent rapid Ca2+ sensitization of contraction in arterial smooth muscle. Circ Res. 2007; 100(1): 121\u20139.","DOI":"10.1161\/01.RES.0000253902.90489.df"},{"key":"70","doi-asserted-by":"crossref","unstructured":"70. Takahashi, R, Nishimura, J, Hirano, K, Seki, N, Naito, S, Kanaide, H. Ca2+ sensitization in contraction of human bladder smooth muscle. J Urol. 2004; 172(2): 748\u201352.","DOI":"10.1097\/01.ju.0000130419.32165.6b"},{"key":"71","doi-asserted-by":"crossref","unstructured":"71. Ohama, T, Hori, M, Sato, K, Ozaki, H, Karaki, H. Chronic treatment with interleukin-1beta attenuates contractions by decreasing the activities of CPI-17 and MYPT-1 in intestinal smooth muscle. J Biol Chem. 2003; 278(49): 48794\u2013804.","DOI":"10.1074\/jbc.M310166200"},{"key":"72","doi-asserted-by":"crossref","unstructured":"72. Ihara, E, Chappellaz, M, Turner, SR, MacDonald, JA. The contribution of protein kinase C and CPI-17 signaling pathways to hypercontractility in murine experimental colitis. Neurogastroenterol Motil. 2012; 24(1): e15\u201326.","DOI":"10.1111\/j.1365-2982.2011.01821.x"},{"key":"73","doi-asserted-by":"crossref","unstructured":"73. Ozaki, H, Yasuda, K, Kim, YS, Egawa, M, Kanzaki, H, Nakazawa, H, Hori, M, Seto, M, Karaki, H. Possible role of the protein kinase C\/CPI-17 pathway in the augmented contraction of human myometrium after gestation. Br J Pharmacol. 2003; 140(7): 1303\u201312.","DOI":"10.1038\/sj.bjp.0705552"},{"key":"74","doi-asserted-by":"crossref","unstructured":"74. Sakai, H, Hirano, T, Takeyama, H, Chiba, Y, Misawa, M. Acetylcholine-induced phosphorylation of CPI-17 in rat bronchial smooth muscle: the roles of Rho-kinase and protein kinase C. Can J Physiol Pharmacol. 2005; 83(4): 375\u201381.","DOI":"10.1139\/y05-022"},{"key":"75","doi-asserted-by":"crossref","unstructured":"75. Sakai, H, Hirano, T, Chiba, Y, Misawa, M. Acetylcholine-induced phosphorylation and membrane translocation of CPI-17 in bronchial smooth muscle of rats. Am J Physiol Lung Cell Mol Physiol. 2005; 289(6): L925\u201330.","DOI":"10.1152\/ajplung.00054.2005"},{"key":"76","doi-asserted-by":"crossref","unstructured":"76. Sakai, H, Chiba, Y, Misawa, M. Role of Rho kinase in endothelin-1-induced phosphorylation of CPI-17 in rat bronchial smooth muscle. Pulm Pharmacol Ther. 2007; 20(6): 734\u20139.","DOI":"10.1016\/j.pupt.2006.08.011"},{"key":"77","doi-asserted-by":"crossref","unstructured":"77. Sakai, H, Chiba, Y, Hirano, T, Misawa, M. Possible involvement of CPI-17 in augmented bronchial smooth muscle contraction in antigen-induced airway hyper-responsive rats. Mol Pharmacol. 2005; 68(1): 145\u201351.","DOI":"10.1124\/mol.104.004325"},{"key":"78","doi-asserted-by":"crossref","unstructured":"78. Sakai, H, Kurihara, Y, Hashimoto, Y, Chiba, Y, Misawa, M. Augmented PDBu-mediated contraction of bronchial smooth muscle of mice with antigen-induced airway hyperresponsiveness. J Smooth Muscle Res. 2010; 46(5): 259\u201366.","DOI":"10.1540\/jsmr.46.259"},{"key":"79","doi-asserted-by":"crossref","unstructured":"79. Kitazawa, T, Eto, M, Woodsome, TP, Brautigan, DL. Agonists trigger G protein-mediated activation of the CPI-17 inhibitor phosphoprotein of myosin light chain phosphatase to enhance vascular smooth muscle contractility. J Biol Chem. 2000; 275(14): 9897\u2013900.","DOI":"10.1074\/jbc.275.14.9897"},{"key":"80","doi-asserted-by":"crossref","unstructured":"80. Goto, K, Chiba, Y, Sakai, H, Misawa, M. Glucocorticoids inhibited airway hyperresponsiveness through downregulation of CPI-17 in bronchial smooth muscle. 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