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Matthews, SG, Gibb, W, Lye, SJ, Challis, JRG. Endocrine and paracrine regulation of birth at term and preterm. Endocr Rev. 2000; 21(5): 514\u201350."},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Norwitz, ER, Robinson, JN, Challis, JR. The control of labor. N Engl J Med. 1999; 341(9): 660\u20136.","DOI":"10.1056\/NEJM199908263410906"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Mesiano, S. Myometrial progesterone responsiveness and the control of human parturition. J Soc Gynecol Investig. 2004; 11(4): 193\u2013202.","DOI":"10.1016\/j.jsgi.2003.12.004"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Tulchinsky, D, Hobel, CJ, Yeager, E, Marshall, JR. Plasma estrone, estradiol, estriol, progesterone, and 17-hydroxyprogesterone in human pregnancy. I. Normal pregnancy. Am J Obstet Gynecol. 1972; 112(8): 1095\u2013100.","DOI":"10.1016\/0002-9378(72)90185-8"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Walsh, SW, Stanczyk, FZ, Novy, MJ. Daily hormonal changes in the maternal, fetal, and amniotic fluid compartments before parturition in a primate species. J Clin Endocrinol Metab. 1984; 58(4): 629\u201339.","DOI":"10.1210\/jcem-58-4-629"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Smith, R, Smith, JI, Shen, X, Engel, PJ, Bowman, ME, McGrath, SA, Bisits, AM, McElduff, P, Giles, WB, Smith, DW. Patterns of plasma corticotropin-releasing hormone, progesterone, estradiol, and estriol change and the onset of human labor. J Clin Endocrinol Metab. 2009; 94(6): 2066\u201374.","DOI":"10.1210\/jc.2008-2257"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. De Hertogh, R, Thomas, K, Bietlot, Y, Vanderheyden, I, Ferin, J. Plasma levels of unconjugated estrone, estradiol and estriol and of HCS throughout pregnancy in normal women. J Clin Endocrinol Metab. 1975; 40(1): 93\u2013101.","DOI":"10.1210\/jcem-40-1-93"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Mesiano, S, Chan, EC, Fitter, JT, Kwek, K, Yeo, G, Smith, R. Progesterone withdrawal and estrogen activation in human parturition are coordinated by progesterone receptor A expression in the myometrium. J Clin Endocrinol Metab. 2002; 87(6): 2924\u201330.","DOI":"10.1210\/jcem.87.6.8609"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Welsh, T, Johnson, M, Yi, L, Tan, H, Rahman, R, Merlino, A, Zakar, T, Mesiano, S. Estrogen receptor (ER) expression and function in the pregnant human myometrium: estradiol via ER\u03b1 activates ERK1\/2 signaling in term myometrium. J Endocrinol. 2012; 212(2): 227\u201338.","DOI":"10.1530\/JOE-11-0358"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Wathes, DC, Smith, HF, Leung, ST, Stevenson, KR, Meier, S, Jenkin, G. Oxytocin receptor development in ovine uterus and cervix throughout pregnancy and at parturition as determined by in situ hybridization analysis. J Reprod Fertil. 1996; 106(1): 23\u201331.","DOI":"10.1530\/jrf.0.1060023"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Fuchs, AR, Fuchs, F, Husslein, P, Soloff, MS. Oxytocin receptors in the human uterus during pregnancy and parturition. Am J Obstet Gynecol. 1984; 150(6): 734\u201341.","DOI":"10.1016\/0002-9378(84)90677-X"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Bossmar, T, Akerlund, M, Fantoni, G, Szamatowicz, J, Melin, P, Maggi, M. Receptors for and myometrial responses to oxytocin and vasopressin in preterm and term human pregnancy: effects of the oxytocin antagonist atosiban. Am J Obstet Gynecol. 1994; 171(6): 1634\u201342.","DOI":"10.1016\/0002-9378(94)90415-4"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Rivera, J, L\u00f3pez Bernal, A, Varney, M, Watson, SP. Inositol 1,4,5-trisphosphate and oxytocin binding in human myometrium. Endocrinology. 1990; 127(1): 155\u201362.","DOI":"10.1210\/endo-127-1-155"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Chan, YW, van den Berg, HA, Moore, JD, Quenby, S, Blanks, AM. Assessment of myometrial transcriptome changes associated with spontaneous human labour by high-throughput RNA-seq. Exp Physiol. 2014; 99(3): 510\u201324.","DOI":"10.1113\/expphysiol.2013.072868"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Kim, SH, MacIntyre, DA, Firmino Da Silva, M, Blanks, AM, Lee, YS, Thornton, S, Bennett, PR, Terzidou, V. Oxytocin activates NF-\u03baB-mediated inflammatory pathways in human gestational tissues. Mol Cell Endocrinol. 2015; 403: 64\u201377.","DOI":"10.1016\/j.mce.2014.11.008"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Pont, JN, McArdle, CA, L\u00f3pez Bernal, A. Oxytocin-stimulated NFAT transcriptional activation in human myometrial cells. Mol Endocrinol. 2012; 26(10): 1743\u201356.","DOI":"10.1210\/me.2012-1057"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Astle, S, Newton, R, Thornton, S, Vatish, M, Slater, DM. Expression and regulation of prostaglandin E synthase isoforms in human myometrium with labour. Mol Hum Reprod. 2007; 13(1): 69\u201375.","DOI":"10.1093\/molehr\/gal093"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Hayflick, L, Moorhead, PS. The serial cultivation of human diploid cell strains. Exp Cell Res. 1961; 25: 585\u2013621.","DOI":"10.1016\/0014-4827(61)90192-6"},{"key":"19","doi-asserted-by":"publisher","unstructured":"19. Bodnar, AG, Ouellette, M, Frolkis, M, Holt, SE, Chiu, CP, Morin, GB, Harley, CB, Shay, JW, Lichtsteiner, S, Wright, WE. Extension of life-span by introduction of telomerase into normal human cells. Science. 1998; 279(5349): 349\u201352.","DOI":"10.1126\/science.279.5349.349"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Perez-Reyes, N, Halbert, CL, Smith, PP, Benditt, EP, McDougall, JK. Immortalization of primary human smooth muscle cells. Proc Natl Acad Sci USA. 1992; 89(4): 1224\u20138.","DOI":"10.1073\/pnas.89.4.1224"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Qian, J, Hendrix, M, Larsen, WJ, Dorn, GW2nd , Lessard, JL. Establishment and characterization of a conditionally immortalized smooth muscle\/myometrial-like cell line. Mol Reprod Dev. 1997; 47(3): 284\u201394.","DOI":"10.1002\/(SICI)1098-2795(199707)47:3<284::AID-MRD7>3.0.CO;2-H"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Chapdelaine, P, Kang, J, Boucher-Kovalik, S, Caron, N, Tremblay, JP, Fortier, MA. Decidualization and maintenance of a functional prostaglandin system in human endometrial cell lines following transformation with SV40 large T antigen. Mol Hum Reprod. 2006; 12(5): 309\u201319.","DOI":"10.1093\/molehr\/gal034"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Anderson, L, Martin, W, Higgins, C, Nelson, SM, Norman, JE. The effect of progesterone on myometrial contractility, potassium channels, and tocolytic efficacy. Reprod Sci. 2009; 16(11): 1052\u201361.","DOI":"10.1177\/1933719109340926"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Baumbach, J, Shi, SQ, Shi, L, Balducci, J, Coonrod, DV, Garfield, RE. Inhibition of uterine contractility with various tocolytics with and without progesterone: in vitro studies. Am J Obstet Gynecol. 2012; 206(3): 254.e1\u20135 .","DOI":"10.1016\/j.ajog.2011.12.011"},{"key":"25","doi-asserted-by":"publisher","unstructured":"25. Tyson, EK, Smith, R, Read, M. Evidence that corticotropin-releasing hormone modulates myometrial contractility during human pregnancy. Endocrinology. 2009; 150(12): 5617\u201325.","DOI":"10.1210\/en.2009-0348"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Paul, J, Maiti, K, Read, M, Hure, A, Smith, J, Chan, EC, Smith, R. Phasic phosphorylation of caldesmon and ERK 1\/2 during contractions in human myometrium. PLoS One. 2011; 6(6): e21542.","DOI":"10.1371\/journal.pone.0021542"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Hudson, CA, Heesom, KJ, L\u00f3pez Bernal, A. Phasic contractions of isolated human myometrium are associated with Rho-kinase (ROCK)-dependent phosphorylation of myosin phosphatase-targeting subunit (MYPT1). Mol Hum Reprod. 2012; 18(5): 265\u201379.","DOI":"10.1093\/molehr\/gar078"},{"key":"28","doi-asserted-by":"publisher","unstructured":"28. Livak, KJ, Schmittgen, TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001; 25(4): 402\u20138.","DOI":"10.1006\/meth.2001.1262"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Mosher, AA, Rainey, KJ, Bolstad, SS, Lye, SJ, Mitchell, BF, Olson, DM, Wood, SL, Slater, DM. Development and validation of primary human myometrial cell culture models to study pregnancy and labour. BMC Pregnancy Childbirth. 2013; 13(Suppl 1): S7.","DOI":"10.1186\/1471-2393-13-S1-S7"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Taggart, MJ, Arthur, P, Zielnik, B, Mitchell, BF. Molecular pathways regulating contractility in rat uterus through late gestation and parturition. Am J Obstet Gynecol. 2012; 207(1): 76.e15\u201324.","DOI":"10.1016\/j.ajog.2012.04.036"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Li, JJ, Biggin, MD. Gene expression. Statistics requantitates the central dogma. Science. 2015; 347(6226): 1066\u20137.","DOI":"10.1126\/science.aaa8332"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Jovanovic, M, Rooney, MS, Mertins, P, Przybylski, D, Chevrier, N, Satija, R, Rodriguez, EH, Fields, AP, Schwartz, S, Raychowdhury, R, Mumbach, MR, Eisenhaure, T, Rabani, M, Gennert, D, Lu, D, Delorey, T, Weissman, JS, Carr, SA, Hacohen, N, Regev, A. Immunogenetics. Dynamic profiling of the protein life cycle in response to pathogens. Science. 2015; 347(6226): 1259038.","DOI":"10.1126\/science.1259038"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Csapo, A. Progesterone block. Am J Anat. 1956; 98(2): 273\u201391.","DOI":"10.1002\/aja.1000980206"},{"key":"34","unstructured":"34. Boroditsky, RS, Reyes, FI, Winter, JS, Faiman, C. Maternal serum estrogen and progesterone concentrations preceding normal labor. Obstet Gynecol. 1978; 51(6): 686\u201391."},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Mesiano, S, Welsh, TN. Steroid hormone control of myometrial contractility and parturition. Semin Cell Dev Biol. 2007; 18(3): 321\u201331.","DOI":"10.1016\/j.semcdb.2007.05.003"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Haluska, GJ, West, NB, Novy, MJ, Brenner, RM. Uterine estrogen receptors are increased by RU486 in late pregnant rhesus macaques but not after spontaneous labor. J Clin Endocrinol Metab. 1990; 70(1): 181\u20136.","DOI":"10.1210\/jcem-70-1-181"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Leavitt, WW, Cobb, AD, Takeda, A. Progesterone-modulation of estrogen action: rapid down regulation of nuclear acceptor sites for the estrogen receptor. Adv Exp Med Biol. 1987; 230: 49\u201378.","DOI":"10.1007\/978-1-4684-1297-0_4"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Kalkhoven, E, Wissink, S, van der Saag, PT, van der Burg, B. Negative interaction between the RelA(p65) subunit of NF-kappaB and the progesterone receptor. J Biol Chem. 1996; 271(11): 6217\u201324.","DOI":"10.1074\/jbc.271.11.6217"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Hardy, DB, Janowski, BA, Corey, DR, Mendelson, CR. Progesterone receptor plays a major antiinflammatory role in human myometrial cells by antagonism of nuclear factor-kappaB activation of cyclooxygenase 2 expression. Mol Endocrinol. 2006; 20(11): 2724\u201333.","DOI":"10.1210\/me.2006-0112"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Renthal, NE, Chen, CC, Williams, KC, Gerard, RD, Prange-Kiel, J, Mendelson, CR. miR-200 family and targets, ZEB1 and ZEB2, modulate uterine quiescence and contractility during pregnancy and labor. Proc Natl Acad Sci USA. 2010; 107(48): 20828\u201333.","DOI":"10.1073\/pnas.1008301107"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Loudon, JA, Sooranna, SR, Bennett, PR, Johnson, MR. Mechanical stretch of human uterine smooth muscle cells increases IL-8 mRNA expression and peptide synthesis. Mol Hum Reprod. 2004; 10(12): 895\u20139.","DOI":"10.1093\/molehr\/gah112"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Sooranna, SR, Lee, Y, Kim, LU, Mohan, AR, Bennett, PR, Johnson, MR. Mechanical stretch activates type 2 cyclooxygenase via activator protein-1 transcription factor in human myometrial cells. Mol Hum Reprod. 2004; 10(2): 109\u201313.","DOI":"10.1093\/molehr\/gah021"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Ou, CW, Chen, ZQ, Qi, S, Lye, SJ. Expression and regulation of the messenger ribonucleic acid encoding the prostaglandin F(2alpha) receptor in the rat myometrium during pregnancy and labor. Am J Obstet Gynecol. 2000; 182(4): 919\u201325.","DOI":"10.1016\/S0002-9378(00)70347-4"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44. Parry, LJ, Bathgate, RA. The role of oxytocin and regulation of uterine oxytocin receptors in pregnant marsupials. Exp Physiol. 2000; 85(Spec No): 91S\u20139S.","DOI":"10.1111\/j.1469-445X.2000.tb00012.x"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45. Wu, WX, Ma, XH, Yoshizato, T, Shinozuka, N, Nathanielsz, PW. Differential expression of myometrial oxytocin receptor and prostaglandin H synthase 2, but not estrogen receptor alpha and heat shock protein 90 messenger ribonucleic acid in the gravid horn and nongravid horn in sheep during betamethasone-induced labor. Endocrinology. 1999; 140(12): 5712\u20138.","DOI":"10.1210\/endo.140.12.7201"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46. Sokolowski, P, Saison, F, Giles, W, McGrath, S, Smith, D, Smith, J, Smith, R. Human uterine wall tension trajectories and the onset of parturition. PLoS One. 2010; 5(6): e11037.","DOI":"10.1371\/journal.pone.0011037"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47. Europe-Finner, GN, Phaneuf, S, Watson, SP, L\u00f3pez Bernal, A. Identification and expression of G-proteins in human myometrium: up-regulation of G alpha s in pregnancy. Endocrinology. 1993; 132(6): 2484\u201390.","DOI":"10.1210\/endo.132.6.8504751"},{"key":"48","unstructured":"48. Europe-Finner, GN, Phaneuf, S, Tolkovsky, AM, Watson, SP, L\u00f3pez Bernal, A. Down-regulation of G alpha s in human myometrium in term and preterm labor: a mechanism for parturition. J Clin Endocrinol Metab. 1994; 79(6): 1835\u20139."},{"key":"49","doi-asserted-by":"crossref","unstructured":"49. L\u00f3pez Bernal, A, Europe-Finner, GN, Phaneuf, S, Watson, SP. Preterm labour: a pharmacological challenge. Trends Pharmacol Sci. 1995; 16(4): 129\u201333.","DOI":"10.1016\/S0165-6147(00)89000-8"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50. Moln\u00e1r, M, Rig\u00f3, JJr. , Romero, R, Hertelendy, F. Oxytocin activates mitogen-activated protein kinase and up-regulates cyclooxygenase-2 and prostaglandin production in human myometrial cells. Am J Obstet Gynecol. 1999; 181(1): 42\u20139.","DOI":"10.1016\/S0002-9378(99)70434-5"},{"key":"51","doi-asserted-by":"crossref","unstructured":"51. Choi, SJ, Oh, S, Kim, JH, Roh, CR. Changes of nuclear factor kappa B (NF-kappaB), cyclooxygenase-2 (COX-2) and matrix metalloproteinase-9 (MMP-9) in human myometrium before and during term labor. Eur J Obstet Gynecol Reprod Biol. 2007; 132(2): 182\u20138.","DOI":"10.1016\/j.ejogrb.2006.07.024"},{"key":"52","doi-asserted-by":"crossref","unstructured":"52. Morrison, JJ, Dearn, SR, Smith, SK, Ahmed, A. Activation of protein kinase C is required for oxytocin-induced contractility in human pregnant myometrium. Hum Reprod. 1996; 11(10): 2285\u201390.","DOI":"10.1093\/oxfordjournals.humrep.a019090"},{"key":"53","doi-asserted-by":"crossref","unstructured":"53. 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