{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:14:39Z","timestamp":1787022879040,"version":"build-2736575974"},"reference-count":82,"publisher":"Japan Society of Smooth Muscle Research","issue":"0","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Smooth Muscle Res","J. Smooth Muscle Res."],"published-print":{"date-parts":[[2022]]},"DOI":"10.1540\/jsmr.58.11","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T18:23:34Z","timestamp":1648578214000},"page":"11-21","source":"Crossref","is-referenced-by-count":7,"title":["The TRPM8 channel as a potential therapeutic target for bladder          hypersensitive disorders"],"prefix":"10.1540","volume":"58","author":[{"given":"Naoki","family":"Aizawa","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, Dokkyo Medical University, 880            Kitakobayashi, Mibu, Tochigi 321-0293, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoe","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Dokkyo Medical University, 880            Kitakobayashi, Mibu, Tochigi 321-0293, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"435","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Abrams,              P,                Cardozo,              L,                Fall,              M,                Griffiths,                D,                Rosier,              P,                Ulmsten,              U, et al.          Standardisation Sub-committee of the International Continence            Society          The standardisation of terminology of lower urinary tract function: report            from the Standardisation Sub-committee of the International Continence            Society. Neurourol Urodyn. 2002;            21(2): 167\u201378.","DOI":"10.1002\/nau.10052"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Irwin,              DE,                Milsom,              I,                Kopp,              Z,                Abrams,              P,                Artibani,              W,                Herschorn,                S.            Prevalence, severity, and symptom bother of lower urinary tract symptoms            among men in the EPIC study: impact of overactive bladder. Eur            Urol. 2009; 56(1):            14\u201320.","DOI":"10.1016\/j.eururo.2009.02.026"},{"issue":"6966","key":"3","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nature02196","volume":"426","year":"2003","unstructured":"3. Clapham,                DE. TRP            channels as cellular sensors. Nature.          2003; 426(6966):            517\u201324.","journal-title":"?Nature","ISSN":"https:\/\/id.crossref.org\/issn\/0028-0836","issn-type":"print"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Gees,              M,                Owsianik,              G,                Nilius,              B,                Voets,              T. TRP            channels. Compr Physiol. 2012;            2(1): 563\u2013608.","DOI":"10.1002\/cphy.c110026"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Ramsey,              IS,                Delling,              M,                Clapham,              DE. An            introduction to TRP channels. Annu Rev Physiol.            2006; 68: 619\u201347.","DOI":"10.1146\/annurev.physiol.68.040204.100431"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Nilius,              B,                Owsianik,              G,                Voets,              T,                Peters,              JA. Transient            receptor potential cation channels in disease. Physiol            Rev. 2007; 87(1):            165\u2013217.","DOI":"10.1152\/physrev.00021.2006"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Nilius,              B,                Szallasi,              A. Transient            receptor potential channels as drug targets: from the science of basic research to the            art of medicine. Pharmacol Rev. 2014;            66(3): 676\u2013814.","DOI":"10.1124\/pr.113.008268"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Moran,              MM. TRP            channels as potential drug targets. Annu Rev Pharmacol            Toxicol. 2018; 58:            309\u201330.","DOI":"10.1146\/annurev-pharmtox-010617-052832"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. de                Groat, WC,                Kawatani,              M,                Hisamitsu,                T,                Cheng,              CL,                Ma,              CP,                Thor,              K, et al.          Mechanisms underlying the recovery of urinary bladder function following            spinal cord injury. J Auton Nerv Syst.            1990; 30(Suppl):            S71\u20137.","DOI":"10.1016\/0165-1838(90)90105-R"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Cruz,              F,                Guimar\u00e4es,                M,                Silva,              C,                Reis,              M. Suppression            of bladder hyperreflexia by intravesical resiniferatoxin.            Lancet. 1997; 350(9078):            640\u20131.","DOI":"10.1016\/S0140-6736(05)63330-2"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. de                S\u00e8ze, M,                Wiart,              L,                de S\u00e8ze,              MP,                Soyeur,              L,                Dosque,              JP,                Blajezewski,                S, et al.          Intravesical capsaicin versus resiniferatoxin for the treatment of detrusor            hyperreflexia in spinal cord injured patients: a double-blind, randomized, controlled            study. J Urol. 2004;            171(1): 251\u20135.","DOI":"10.1097\/01.ju.0000100385.93801.d4"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Fowler,              CJ,                Jewkes,              D,                McDonald,                WI,                Lynn,              B,                de Groat,                WC.            Intravesical capsaicin for neurogenic bladder          dysfunction. Lancet. 1992;            339(8803): 1239.","DOI":"10.1016\/0140-6736(92)91186-C"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Kitagawa,                Y,                Wada,              M,                Kanehisa,              T,                Miyai,              A,                Usui,              K,                Maekawa,              M, et al.          JTS-653 blocks afferent nerve firing and attenuates bladder overactivity            without affecting normal voiding function. J Urol.            2013; 189(3):            1137\u201346.","DOI":"10.1016\/j.juro.2012.09.055"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Andrade,                EL,                Ferreira,              J,                Andr\u00e9,              E,                Calixto,              JB. Contractile            mechanisms coupled to TRPA1 receptor activation in rat urinary bladder.            Biochem Pharmacol. 2006;            72(1): 104\u201314.","DOI":"10.1016\/j.bcp.2006.04.003"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Minagawa,                T,                Aizawa,              N,                Igawa,              Y,                Wyndaele,                JJ. The role            of transient receptor potential ankyrin 1 (TRPA1) channel in activation of single unit            mechanosensitive bladder afferent activities in the rat.            Neurourol Urodyn. 2014;            33(5): 544\u20139.","DOI":"10.1002\/nau.22449"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Koivisto,                A,                Jalava,              N,                Bratty,              R,                Pertovaara,                A. TRPA1            antagonists for pain relief. Pharmaceuticals (Basel).            2018; 11(4): E117.","DOI":"10.3390\/ph11040117"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Takaoka,                EI,                Kurobe,              M,                Okada,              H,                Takai,              S,                Suzuki,              T,                Shimizu,              N, et al.          Effect of TRPV4 activation in a rat model of detrusor underactivity induced            by bilateral pelvic nerve crush injury. Neurourol            Urodyn. 2018; 37(8):            2527\u201334.","DOI":"10.1002\/nau.23790"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Deruyver,                Y,                Weyne,              E,                Dewulf,              K,                Rietjens,              R,                Pinto,              S,                Van Ranst,                N, et al.          Intravesical activation of the cation channel TRPV4 improves bladder            function in a rat model for detrusor underactivity. Eur            Urol. 2018; 74(3):            336\u201345.","DOI":"10.1016\/j.eururo.2018.05.020"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Chapple,                CR,                Osman,              NI,                Birder,              L,                Dmochowski,                R,                Drake,              MJ,                van Koeveringe,                G, et al.          Terminology report from the International Continence Society (ICS) Working            Group on Underactive Bladder (UAB). Neurourol Urodyn.            2018; 37(8):            2928\u201331.","DOI":"10.1002\/nau.23701"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Landour\u00e9,                G,                Zdebik,              AA,                Martinez,                TL,                Burnett,              BG,                Stanescu,                HC,                Inada,              H, et al.          Mutations in TRPV4 cause Charcot-Marie-Tooth disease type            2C. Nat Genet. 2010;            42(2): 170\u20134.","DOI":"10.1038\/ng.512"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Aizawa,              N,                Wyndaele,                JJ,                Homma,              Y,                Igawa,              Y. Effects of            TRPV4 cation channel activation on the primary bladder afferent activities of the            rat. Neurourol Urodyn. 2012;            31(1): 148\u201355.","DOI":"10.1002\/nau.21212"},{"key":"22","doi-asserted-by":"publisher","unstructured":"22. McKemy,              DD,                Neuhausser,                WM,                Julius,              D.            Identification of a cold receptor reveals a general role for TRP channels            in thermosensation. Nature. 2002;            416(6876): 52\u20138.","DOI":"10.1038\/nature719"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Peier,              AM,                Moqrich,              A,                Hergarden,                AC,                Reeve,              AJ,                Andersson,                DA,                Story,              GM, et al.          A TRP channel that senses cold stimuli and menthol.            Cell. 2002; 108(5):            705\u201315.","DOI":"10.1016\/S0092-8674(02)00652-9"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Kobayashi,                K,                Fukuoka,              T,                Obata,              K,                Yamanaka,              H,                Dai,              Y,                Tokunaga,              A, et al.          Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary            afferent neurons with adelta\/c-fibers and colocalization with trk            receptors. J Comp Neurol. 2005;            493(4): 596\u2013606.","DOI":"10.1002\/cne.20794"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Stein,              RJ,                Santos,              S,                Nagatomi,              J,                Hayashi,              Y,                Minnery,              BS,                Xavier,              M, et al.          Cool (TRPM8) and hot (TRPV1) receptors in the bladder and male genital            tract. J Urol. 2004;            172(3): 1175\u20138.","DOI":"10.1097\/01.ju.0000134880.55119.cf"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Gardiner,                JC,                Kirkup,              AJ,                Curry,              J,                Humphreys,                S,                O\u2019Regan,              P,                Postlethwaite,                M, et al.          The role of TRPM8 in the Guinea-pig bladder-cooling reflex investigated            using a novel TRPM8 antagonist. Eur J Pharmacol.            2014; 740: 398\u2013409.","DOI":"10.1016\/j.ejphar.2014.07.022"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Mukerji,              G,                Yiangou,              Y,                Corcoran,                SL,                Selmer,              IS,                Smith,              GD,                Benham,              CD, et al.          Cool and menthol receptor TRPM8 in human urinary bladder disorders and            clinical correlations. BMC Urol. 2006;            6: 6.","DOI":"10.1186\/1471-2490-6-6"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Drake,              MJ. Do we need            a new definition of the overactive bladder syndrome? ICI-RS 2013.            Neurourol Urodyn. 2014;            33(5): 622\u20134.","DOI":"10.1002\/nau.22609"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Brading,                AF. A            myogenic basis for the overactive bladder. Urology.            1997; 50(6A          Suppl): 57\u201367 discussion 68\u201373.","DOI":"10.1016\/S0090-4295(97)00591-8"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Drake,              MJ,                Harvey,              IJ,                Gillespie,                JI,                Van Duyl,                WA. Localized            contractions in the normal human bladder and in urinary urgency.            BJU Int. 2005; 95(7):            1002\u20135.","DOI":"10.1111\/j.1464-410X.2005.05455.x"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Andersson,                KE,                Soler,              R,                F\u00fcllhase,              C. Rodent            models for urodynamic investigation. Neurourol Urodyn.            2011; 30(5):            636\u201346.","DOI":"10.1002\/nau.21108"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Igawa,              Y,                Mattiasson,                A,                Andersson,                KE.            Micturition and premicturition contractions in unanesthetized rats with            bladder outlet obstruction. J Urol. 1994;            151(1): 244\u20139.","DOI":"10.1016\/S0022-5347(17)34925-X"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Homma,              Y,                Akiyama,              Y,                Tomoe,              H,                Furuta,              A,                Ueda,              T,                Maeda,              D, et al.          Clinical guidelines for interstitial cystitis\/bladder pain            syndrome. Int J Urol. 2020;            27(7): 578\u201389.","DOI":"10.1111\/iju.14234"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. de                Groat, WC.            The urothelium in overactive bladder: passive bystander or active            participant?          Urology. 2004; 64(6          Suppl 1): 7\u201311.","DOI":"10.1016\/j.urology.2004.08.063"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Jiang,              W,                Morrison,              J.            Sensitisation of pelvic nerve afferent neurones from the rat            bladder. J Auton Nerv Syst. 1996;            58: 181\u2013231.","DOI":"10.1016\/0165-1838(96)84704-7"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Gabella,              G,                Davis,              C. Distribution            of afferent axons in the bladder of rats. J Neurocytol.            1998; 27(3):            141\u201355.","DOI":"10.1023\/A:1006903507321"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Ouslander,                JG.            Management of overactive bladder. N Engl J            Med. 2004; 350(8):            786\u201399.","DOI":"10.1056\/NEJMra032662"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Vera,              PL,                Nadelhaft,                I. Anatomical            evidence for two spinal \u2018afferent-interneuron-efferent\u2019 reflex pathways involved in            micturition in the rat: a \u2018pelvic nerve\u2019 reflex pathway and a \u2018sacrolumbar            intersegmental\u2019 reflex pathway. Brain Res.            2000; 883(1):            107\u201318.","DOI":"10.1016\/S0006-8993(00)02732-3"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. H\u00e4bler,              HJ,                J\u00e4nig,              W,                Koltzenburg,                M. Activation            of unmyelinated afferent fibres by mechanical stimuli and inflammation of the urinary            bladder in the cat. J Physiol. 1990;            425: 545\u201362.","DOI":"10.1113\/jphysiol.1990.sp018117"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. H\u00e4bler,              HJ,                J\u00e4nig,              W,                Koltzenburg,                M. Myelinated            primary afferents of the sacral spinal cord responding to slow filling and distension of            the cat urinary bladder. J Physiol. 1993;            463: 449\u201360.","DOI":"10.1113\/jphysiol.1993.sp019604"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Morrison,                J,                Wen,              J,                Kibble,              A. Activation            of pelvic afferent nerves from the rat bladder during filling.            Scand J Urol Nephrol Suppl. 1999; 201:            73\u20135.","DOI":"10.1080\/003655999750016348-1"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Shea,              VK,                Cai,              R,                Crepps,              B,                Mason,              JL,                Perl,              ER. Sensory            fibers of the pelvic nerve innervating the Rat\u2019s urinary bladder.            J Neurophysiol. 2000;          84(4): 1924\u201333.","DOI":"10.1152\/jn.2000.84.4.1924"},{"key":"43","doi-asserted-by":"publisher","unstructured":"43. Bautista,                DM,                Siemens,              J,                Glazer,              JM,                Tsuruda,              PR,                Basbaum,              AI,                Stucky,              CL, et al.          The menthol receptor TRPM8 is the principal detector of environmental            cold. Nature. 2007;            448(7150): 204\u20138.","DOI":"10.1038\/nature05910"},{"key":"44","doi-asserted-by":"publisher","unstructured":"44. Colburn,                RW,                Lubin,              ML,                Stone,                DJJr ,                Wang,              Y,                Lawrence,              D,                D\u2019Andrea,                MR, et al.          Attenuated cold sensitivity in TRPM8 null mice.            Neuron. 2007; 54(3):            379\u201386.","DOI":"10.1016\/j.neuron.2007.04.017"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45. Xing,              H,                Chen,              M,                Ling,              J,                Tan,              W,                Gu,              JG. TRPM8            mechanism of cold allodynia after chronic nerve injury. J            Neurosci. 2007; 27(50):            13680\u201390.","DOI":"10.1523\/JNEUROSCI.2203-07.2007"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46. Knowlton,                WM,                Daniels,              RL,                Palkar,              R,                McCoy,              DD,                McKemy,              DD.            Pharmacological blockade of TRPM8 ion channels alters cold and cold pain            responses in mice. PLoS One. 2011;            6(9): e25894.","DOI":"10.1371\/journal.pone.0025894"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47. Gauchan,              P,                Andoh,              T,                Kato,              A,                Kuraishi,              Y. Involvement            of increased expression of transient receptor potential melastatin 8 in            oxaliplatin-induced cold allodynia in mice. Neurosci            Lett. 2009; 458(2):            93\u20135.","DOI":"10.1016\/j.neulet.2009.04.029"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48. Descoeur,                J,                Pereira,              V,                Pizzoccaro,                A,                Francois,              A,                Ling,              B,                Maffre,              V, et al.          Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion            channel expression in nociceptors. EMBO Mol Med.            2011; 3(5):            266\u201378.","DOI":"10.1002\/emmm.201100134"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49. Ito,              H,                Aizawa,              N,                Sugiyama,              R,                Watanabe,              S,                Takahashi,                N,                Tajimi,              M, et al.          Functional role of the transient receptor potential melastatin 8 (TRPM8)            ion channel in the urinary bladder assessed by conscious cystometry and ex vivo            measurements of single-unit mechanosensitive bladder afferent activities in the            rat. BJU Int. 2016;            117(3): 484\u201394.","DOI":"10.1111\/bju.13225"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50. Aizawa,              N,                Fujimori,              Y,                Kobayashi,                JI,                Nakanishi,                O,                Hirasawa,              H,                Kume,              H, et al.          KPR-2579, a novel TRPM8 antagonist, inhibits acetic acid-induced bladder            afferent hyperactivity in rats. Neurourol Urodyn.            2018; 37(5):            1633\u201340.","DOI":"10.1002\/nau.23532"},{"key":"51","doi-asserted-by":"crossref","unstructured":"51. Aizawa,              N,                Ohshiro,              H,                Watanabe,              S,                Kume,              H,                Homma,              Y,                Igawa,              Y. RQ-00434739,            a novel TRPM8 antagonist, inhibits prostaglandin E2-induced hyperactivity of the primary            bladder afferent nerves in rats. Life Sci.            2019; 218: 89\u201395.","DOI":"10.1016\/j.lfs.2018.12.031"},{"key":"52","doi-asserted-by":"crossref","unstructured":"52. Nakanishi,                O,                Fujimori,              Y,                Aizawa,              N,                Hayashi,              T,                Matsuzawa,                A,                Kobayashi,                JI, et al.          KPR-5714, a novel transient receptor potential melastatin 8 antagonist,            improves overactive bladder via inhibition of bladder afferent hyperactivity in            rats. J Pharmacol Exp Ther. 2020;            373(2): 239\u201347.","DOI":"10.1124\/jpet.119.263616"},{"key":"53","doi-asserted-by":"crossref","unstructured":"53. Aizawa,              N,                Fujimori,              Y,                Nakanishi,                O,                Hayashi,              T,                Goi,              Y,                Kobayashi,                JI, et al.          Efficacy of the combination of KPR-5714, a novel transient receptor            potential melastatin 8 (TRPM8) antagonist, and \u03b2<sub>3<\/sub>-adrenoceptor agonist or            anticholinergic agent on bladder dysfunction in rats with bladder            overactivity. Eur J Pharmacol. 2021;            899: 173995.","DOI":"10.1016\/j.ejphar.2021.173995"},{"key":"54","doi-asserted-by":"crossref","unstructured":"54. Hayashi,              T,                Kondo,              T,                Ishimatsu,                M,                Takeya,              M,                Igata,              S,                Nakamura,              K, et al.          Function and expression pattern of TRPM8 in bladder afferent neurons            associated with bladder outlet obstruction in rats. Auton            Neurosci. 2011; 164(1-2):            27\u201333.","DOI":"10.1016\/j.autneu.2011.05.006"},{"key":"55","doi-asserted-by":"crossref","unstructured":"55. Jun,              JH,                Kang,              HJ,                Jin,              MH,                Lee,              HY,                Im,              YJ,                Jung,              HJ, et al.          Function of the cold receptor (TRPM8) associated with voiding dysfunction            in bladder outlet obstruction in rats. Int Neurourol J.            2012; 16(2):            69\u201376.","DOI":"10.5213\/inj.2012.16.2.69"},{"key":"56","doi-asserted-by":"crossref","unstructured":"56. Mukerji,              G,                Waters,              J,                Chessell,                IP,                Bountra,              C,                Agarwal,              SK,                Anand,              P. Pain during            ice water test distinguishes clinical bladder hypersensitivity from overactivity            disorders. BMC Urol. 2006;            6: 31.","DOI":"10.1186\/1471-2490-6-31"},{"key":"57","doi-asserted-by":"crossref","unstructured":"57. Chen,              Z,                Ishizuka,              O,                Imamura,              T,                Aizawa,              N,                Kurizaki,              Y,                Igawa,              Y, et al.          Stimulation of skin menthol receptors stimulates detrusor activity in            conscious rats. Neurourol Urodyn. 2010;            29(3): 506\u201311.","DOI":"10.1002\/nau.20774"},{"key":"58","doi-asserted-by":"crossref","unstructured":"58. Uvin,              P,                Franken,              J,                Pinto,              S,                Rietjens,              R,                Grammet,              L,                Deruyver,              Y, et al.          Essential role of transient receptor potential M8 (TRPM8) in a model of            acute cold-induced urinary urgency. Eur Urol.            2015; 68(4):            655\u201361.","DOI":"10.1016\/j.eururo.2015.03.037"},{"key":"59","doi-asserted-by":"crossref","unstructured":"59. Imamura,              T,                Ishizuka,              O,                Nishizawa,                O. Cold            stress induces lower urinary tract symptoms. Int J          Urol. 2013; 20(7):            661\u20139.","DOI":"10.1111\/iju.12129"},{"key":"60","doi-asserted-by":"crossref","unstructured":"60. Roehrborn,                CG. Male            lower urinary tract symptoms (LUTS) and benign prostatic hyperplasia            (BPH). Med Clin North Am. 2011;            95(1): 87\u2013100.","DOI":"10.1016\/j.mcna.2010.08.013"},{"key":"61","doi-asserted-by":"crossref","unstructured":"61. Du,                S,                Araki,              I,                Kobayashi,                H,                Zakoji,              H,                Sawada,              N,                Takeda,              M. Differential            expression profile of cold (TRPA1) and cool (TRPM8) receptors in human urogenital            organs. Urology. 2008;            72(2): 450\u20135.","DOI":"10.1016\/j.urology.2007.11.127"},{"key":"62","doi-asserted-by":"crossref","unstructured":"62. Homma,              Y,                Nomiya,              A,                Tagaya,              M,                Oyama,              T,                Takagaki,              K,                Nishimatsu,                H, et al.          Increased mRNA expression of genes involved in pronociceptive inflammatory            reactions in bladder tissue of interstitial cystitis. J            Urol. 2013; 190(5):            1925\u201331.","DOI":"10.1016\/j.juro.2013.05.049"},{"key":"63","doi-asserted-by":"crossref","unstructured":"63. Wu,                L,                Zhang,              J,                Zhou,              F,                Zhang,              P. Increased            transient receptor potential melastatin 8 expression in the development of bladder pain            in patients with interstitial cystitis\/bladder pain syndrome.            Urology. 2020; 146:            301.e1\u20136.","DOI":"10.1016\/j.urology.2020.09.037"},{"key":"64","unstructured":"64. Ohshiro,              H,                Fujiuchi,              A,                Yamada,              A,                Gaja,              N,                Sato,              A,                Isogai,              Y, et al. In          vitro and in vivo characterization of RQ-00434739: a novel orally active and selective          TRPM8 antagonist for the treatment of oxaliplatin-induced peripheral neuropathic pain. In:          IASP, editor. The 16th World Congress on Pain; Sep 27; Yokohama, Japan, 2016.          Poster No. 284."},{"key":"65","doi-asserted-by":"crossref","unstructured":"65. Kobayashi,                JI,                Hirasawa,              H,                Ozawa,              T,                Ozawa,              T,                Takeda,              H,                Fujimori,              Y, et al.          Synthesis and optimization of novel \u03b1-phenylglycinamides as selective TRPM8            antagonists. Bioorg Med Chem. 2017;            25(2): 727\u201342.","DOI":"10.1016\/j.bmc.2016.11.049"},{"key":"66","doi-asserted-by":"crossref","unstructured":"66. Ohmi,              M,                Shishido,              Y,                Inoue,              T,                Ando,              K,                Fujiuchi,              A,                Yamada,              A, et al.          Identification of a novel 2-pyridyl-benzensulfonamide derivative,            RQ-00203078, as a selective and orally active TRPM8 antagonist.            Bioorg Med Chem Lett. 2014;            24(23): 5364\u20138.","DOI":"10.1016\/j.bmcl.2014.10.074"},{"key":"67","doi-asserted-by":"crossref","unstructured":"67. Almeida,                MC,                Hew-Butler,                T,                Soriano,              RN,                Rao,              S,                Wang,              W,                Wang,              J, et al.          Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic            and behavioral cold defenses and decreases deep body temperature.            J Neurosci. 2012; 32(6):            2086\u201399.","DOI":"10.1523\/JNEUROSCI.5606-11.2012"},{"key":"68","doi-asserted-by":"crossref","unstructured":"68. Andrews,                MD,                Af Forselles,                K,                Beaumont,              K,                Galan,              SR,                Glossop,              PA,                Grenie,              M, et al.          Discovery of a selective TRPM8 antagonist with clinical efficacy in            cold-related pain. ACS Med Chem Lett.          2015; 6(4):            419\u201324.","DOI":"10.1021\/ml500479v"},{"key":"69","doi-asserted-by":"crossref","unstructured":"69. Horne,              DB,                Biswas,              K,                Brown,              J,                Bartberger,                MD,                Clarine,              J,                Davis,              CD, et al.          Discovery of TRPM8 Antagonist (            S)-6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic            Acid (AMG 333), a Clinical Candidate for the Treatment of Migraine.            J Med Chem. 2018; 61(18):            8186\u2013201.","DOI":"10.1021\/acs.jmedchem.8b00518"},{"key":"70","doi-asserted-by":"crossref","unstructured":"70. Liu,              Y,                Mikrani,              R,                He,              Y,                Faran Ashraf Baig,                MM,                Abbas,              M,                Naveed,              M, et al.          TRPM8 channels: a review of distribution and clinical role.            Eur J Pharmacol. 2020; 882:            173312.","DOI":"10.1016\/j.ejphar.2020.173312"},{"key":"71","doi-asserted-by":"crossref","unstructured":"71. Aizawa,              N,                Fukuhara,              H,                Fujimura,              T,                Homma,              Y,                Igawa,              Y. Direct            influence of systemic desensitization by resiniferatoxin on the activities of A\u03b4- and            C-fibers in the rat primary bladder mechanosensitive afferent nerves.            Int J Urol. 2016; 23(11):            952\u20136.","DOI":"10.1111\/iju.13181"},{"key":"72","doi-asserted-by":"crossref","unstructured":"72. Aizawa,              N,                Igawa,              Y,                Andersson,                KE,                Iijima,              K,                Nishizawa,                O,                Wyndaele,                JJ. Effects            of intravesical instillation of ATP on rat bladder primary afferent activity and its            relationship with capsaicin-sensitivity. Neurourol            Urodyn. 2011; 30(1):            163\u20138.","DOI":"10.1002\/nau.20940"},{"key":"73","doi-asserted-by":"crossref","unstructured":"73. Aizawa,              N,                Ito,              H,                Sugiyama,              R,                Fujimura,              T,                Suzuki,              M,                Fukuhara,              H, et al.          Selective inhibitory effect of imidafenacin and 5-hydroxymethyl tolterodine            on capsaicin sensitive C fibers of the primary bladder mechanosensitive afferent nerves            in the rat. J Urol. 2015;            193(4): 1423\u201332.","DOI":"10.1016\/j.juro.2014.09.005"},{"key":"74","doi-asserted-by":"crossref","unstructured":"74. Caprodossi,                S,                Lucciarini,                R,                Amantini,              C,                Nabissi,              M,                Canesin,              G,                Ballarini,                P, et al.          Transient receptor potential vanilloid type 2 (TRPV2) expression in normal            urothelium and in urothelial carcinoma of human bladder: correlation with the pathologic            stage. Eur Urol. 2008;            54(3): 612\u201320.","DOI":"10.1016\/j.eururo.2007.10.016"},{"key":"75","doi-asserted-by":"crossref","unstructured":"75. Jin,              M,                Wu,              Z,                Chen,              L,                Jaimes,              J,                Collins,              D,                Walters,              ET, et al.          Determinants of TRPV4 activity following selective activation by small            molecule agonist GSK1016790A. PLoS One.            2011; 6(2): e16713.","DOI":"10.1371\/journal.pone.0016713"},{"key":"76","doi-asserted-by":"crossref","unstructured":"76. Everaerts,                W,                Zhen,              X,                Ghosh,              D,                Vriens,              J,                Gevaert,              T,                Gilbert,              JP, et al.          Inhibition of the cation channel TRPV4 improves bladder function in mice            and rats with cyclophosphamide-induced cystitis. Proc Natl Acad            Sci USA. 2010; 107(44):            19084\u20139.","DOI":"10.1073\/pnas.1005333107"},{"key":"77","doi-asserted-by":"crossref","unstructured":"77. Gevaert,              T,                Vriens,              J,                Segal,              A,                Everaerts,                W,                Roskams,              T,                Talavera,              K, et al.          Deletion of the transient receptor potential cation channel TRPV4 impairs            murine bladder voiding. J Clin Invest.            2007; 117(11):            3453\u201362.","DOI":"10.1172\/JCI31766"},{"key":"78","doi-asserted-by":"crossref","unstructured":"78. Yu,                W,                Hill,              WG,                Apodaca,              G,                Zeidel,              ML. Expression            and distribution of transient receptor potential (TRP) channels in bladder            epithelium. Am J Physiol Renal Physiol.            2011; 300(1):            F49\u201359.","DOI":"10.1152\/ajprenal.00349.2010"},{"key":"79","doi-asserted-by":"crossref","unstructured":"79. Kamei,              J,                Aizawa,              N,                Nakagawa,              T,                Kaneko,              S,                Fujimura,              T,                Homma,              Y, et al.          Lacking transient receptor potential melastatin\u00a02 attenuates            lipopolysaccharide-induced bladder inflammation and its associated hypersensitivity in            mice. Int J Urol. 2021;            28(1): 107\u201314.","DOI":"10.1111\/iju.14389"},{"key":"80","doi-asserted-by":"crossref","unstructured":"80. Watanabe,                M,                Suzuki,              Y,                Uchida,              K,                Miyazaki,              N,                Murata,              K,                Matsumoto,                S, et al.          Trpm7 protein contributes to intercellular junction formation in mouse            urothelium. J Biol Chem. 2015;            290(50): 29882\u201392.","DOI":"10.1074\/jbc.M115.667899"},{"key":"81","doi-asserted-by":"crossref","unstructured":"81. Mistretta,                FA,                Russo,              A,                Castiglione,                F,                Bettiga,              A,                Colciago,              G,                Montorsi,              F, et al.          DFL23448, a novel transient receptor potential melastin 8-selective ion            channel antagonist, modifies bladder function and reduces bladder overactivity in awake            rats. J Pharmacol Exp Ther. 2016;            356(1): 200\u201311.","DOI":"10.1124\/jpet.115.228684"},{"key":"82","doi-asserted-by":"crossref","unstructured":"82. Kamei,              J,                Aizawa,              N,                Nakagawa,              T,                Kaneko,              S,                Kume,              H,                Homma,              Y, et al.          Attenuated lipopolysaccharide-induced inflammatory bladder hypersensitivity            in mice deficient of transient receptor potential ankilin1. Sci            Rep. 2018; 8(1):            15622.","DOI":"10.1038\/s41598-018-33967-x"}],"container-title":["Journal of Smooth Muscle Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jsmr\/58\/0\/58_0528\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T03:04:09Z","timestamp":1648868649000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jsmr\/58\/0\/58_0528\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":82,"journal-issue":{"issue":"0","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.1540\/jsmr.58.11","relation":{},"ISSN":["0916-8737","1884-8796"],"issn-type":[{"value":"0916-8737","type":"print"},{"value":"1884-8796","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]},"article-number":"0528"}}