{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T18:43:50Z","timestamp":1776365030908,"version":"3.51.2"},"reference-count":34,"publisher":"Japan Society of Smooth Muscle Research","issue":"0","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Smooth Muscle Res","J. Smooth Muscle Res."],"published-print":{"date-parts":[[2022]]},"DOI":"10.1540\/jsmr.58.78","type":"journal-article","created":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T22:23:42Z","timestamp":1665181422000},"page":"78-88","source":"Crossref","is-referenced-by-count":9,"title":["Hangekobokuto, a traditional Japanese herbal medicine, ameliorates          postoperative ileus through its anti-inflammatory action"],"prefix":"10.1540","volume":"58","author":[{"given":"Mari","family":"Endo","sequence":"first","affiliation":[{"name":"Department of Clinical Research, Oriental Medicine Research Center,            Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8642, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuro","family":"Oikawa","sequence":"additional","affiliation":[{"name":"Center for Kampo Medicine, Tokyo Medical University Hospital, 6-7-1            Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miki","family":"Tonooka","sequence":"additional","affiliation":[{"name":"Graduate School of Infection Control Sciences, Kitasato University,            5-9-1 Shirokane, Minato-ku, Tokyo 108-8642, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiko","family":"Hanawa","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Oriental Medicine Research Center,            Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8642, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Odaguchi","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Oriental Medicine Research Center,            Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8642, Japan"},{"name":"Oriental Medicine, Doctoral Program of Medical Science, Kitasato            University Graduate School, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8642, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoshi","family":"Hori","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pharmacology, Graduate School of Agriculture            and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657,            Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"435","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Prasad, M, Matthews, JB. Deflating postoperative ileus. Gastroenterology. 1999; 117(2): 489\u201392.","DOI":"10.1053\/gast.1999.0029900489"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Livingston, EH, Passaro, EP Jr. Postoperative ileus. Dig Dis Sci. 1990; 35(1): 121\u201332.","DOI":"10.1007\/BF01537233"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Bauer, AJ, Boeckxstaens, GE. Mechanisms of postoperative ileus. Neurogastroenterol Motil. 2004; 16(Suppl 2): 54\u201360.","DOI":"10.1111\/j.1743-3150.2004.00558.x"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Kalff, JC, Carlos, TM, Schraut, WH, Billiar, TR, Simmons, RL, Bauer, AJ. Surgically induced leukocytic infiltrates within the rat intestinal muscularis mediate postoperative ileus. Gastroenterology. 1999; 117(2): 378\u201387.","DOI":"10.1053\/gast.1999.0029900378"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Kalff, JC, Schraut, WH, Billiar, TR, Simmons, RL, Bauer, AJ. Role of inducible nitric oxide synthase in postoperative intestinal smooth muscle dysfunction in rodents. Gastroenterology. 2000; 118(2): 316\u201327.","DOI":"10.1016\/S0016-5085(00)70214-9"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Wehner, S, Behrendt, FF, Lyutenski, BN, Lysson, M, Bauer, AJ, Hirner, A, et al. Inhibition of macrophage function prevents intestinal inflammation and postoperative ileus in rodents. Gut. 2007; 56(2): 176\u201385.","DOI":"10.1136\/gut.2005.089615"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Tsuchida, Y, Hatao, F, Fujisawa, M, Murata, T, Kaminishi, M, Seto, Y, et al. Neuronal stimulation with 5-hydroxytryptamine 4 receptor induces anti-inflammatory actions via \u03b17nACh receptors on muscularis macrophages associated with postoperative ileus. Gut. 2011; 60(5): 638\u201347.","DOI":"10.1136\/gut.2010.227546"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Endo, M, Hori, M, Ozaki, H, Oikawa, T, Hanawa, T. Daikenchuto, a traditional Japanese herbal medicine, ameliorates postoperative ileus by anti-inflammatory action through nicotinic acetylcholine receptors. J Gastroenterol. 2014; 49(6): 1026\u201339.","DOI":"10.1007\/s00535-013-0854-6"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Endo, M, Hori, M, Ozaki, H, Oikawa, T, Hanawa, T. Rikkunshito, a Kampo medicine, ameliorates post-operative ileus by anti-inflammatory action. J Pharmacol Sci. 2014; 124(3): 374\u201385.","DOI":"10.1254\/jphs.13182FP"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Oikawa, T, Ito, G, Hoshino, T, Koyama, H, Hanawa, T. Hangekobokuto (Banxia-houpo-tang), a Kampo medicine that treats functional dyspepsia. Evid Based Complement Alternat Med. 2009; 6(3): 375\u20138.","DOI":"10.1093\/ecam\/nem101"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Kagohashi, K, Tamura, T, Ohara, G, Satoh, H. Effect of a traditional herbal medicine, hangekobokuto, on the sensation of a lump in the throat in patients with respiratory diseases. Biomed Rep. 2016; 4(3): 384\u20136.","DOI":"10.3892\/br.2016.592"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Oikawa, T, Yakazu, Y, Hirasawa, K, Yamaguchi, Y, Harada, Y. Two cases of functional abdominal bloating successfully treated with hangekobokuto. Tradit Kampo Med. 2022; (in press).","DOI":"10.1002\/tkm2.1342"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Hirano, Y, Isai, H, Onuki, A, Watanabe, K. Integrative treatment of paralytic small intestine following acute cervical cord injury: A case report. Surg Neurol Int. 2020; 11: 80.","DOI":"10.25259\/SNI_62_2020"},{"key":"14","doi-asserted-by":"publisher","unstructured":"14. Mihara, T, Mikawa, S, Kaji, N, Endo, M, Oikawa, T, Tong-Rong, J, et al. Therapeutic action of Honokiol on postoperative ileus via downregulation of iNOS gene expression. Inflammation. 2017; 40(4): 1331\u201341.","DOI":"10.1007\/s10753-017-0576-7"},{"key":"15","doi-asserted-by":"publisher","unstructured":"15. Schwarz, NT, Kalff, JC, T\u00fcrler, A, Engel, BM, Watkins, SC, Billiar, TR, et al. Prostanoid production via COX-2 as a causative mechanism of rodent postoperative ileus. Gastroenterology. 2001; 121(6): 1354\u201371.","DOI":"10.1053\/gast.2001.29605"},{"key":"16","doi-asserted-by":"publisher","unstructured":"16. Schmidt, J, Stoffels, B, Moore, BA, Chanthaphavong, RS, Mazie, AR, Buchholz, BM, et al. Proinflammatory role of leukocyte-derived Egr-1 in the development of murine postoperative ileus. Gastroenterology. 2008; 135(3): 926\u201336 936.e1\u20132.","DOI":"10.1053\/j.gastro.2008.05.079"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Uchida, M, Endo, N, Shimizu, K. Simple and noninvasive breath test using 13C-acetic acid to evaluate gastric emptying in conscious rats and its validation by metoclopramide. J Pharmacol Sci. 2005; 98(4): 388\u201395.","DOI":"10.1254\/jphs.FP0050153"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Hoshino, T, Oikawa, T, Endo, M, Hanawa, T. The utility of noninvasive (13)C-acetate breath test using a new solid test meal to measure gastric emptying in mice. J Smooth Muscle Res. 2008; 44(5): 159\u201365.","DOI":"10.1540\/jsmr.44.159"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Kinoshita, K, Horiguchi, K, Fujisawa, M, Kobirumaki, F, Yamato, S, Hori, M, et al. Possible involvement of muscularis resident macrophages in impairment of interstitial cells of Cajal and myenteric nerve systems in rat models of TNBS-induced colitis. Histochem Cell Biol. 2007; 127(1): 41\u201353.","DOI":"10.1007\/s00418-006-0223-0"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Hori, M, Kita, M, Torihashi, S, Miyamoto, S, Won, KJ, Sato, K, et al. Upregulation of iNOS by COX-2 in muscularis resident macrophage of rat intestine stimulated with LPS. Am J Physiol Gastrointest Liver Physiol. 2001; 280(5): G930\u20138.","DOI":"10.1152\/ajpgi.2001.280.5.G930"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Sheibani, K, Lucas, FV, Tubbs, RR, Savage, RA, Hoeltge, GA. Alternate chromogens as substitutes for benzidine for myeloperoxidase cytochemistry. Am J Clin Pathol. 1981; 75(3): 367\u201370.","DOI":"10.1093\/ajcp\/75.3.367"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Docsa, T, Bhattarai, D, Sipos, A, Wade, CE, Cox, CS Jr, Uray, K. CXCL1 is upregulated during the development of ileus resulting in decreased intestinal contractile activity. Neurogastroenterol Motil. 2020; 32(3): e13757.","DOI":"10.1111\/nmo.13757"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Stein, K, Hieggelke, L, Schneiker, B, Lysson, M, Stoffels, B, Nuding, S, et al. Intestinal manipulation affects mucosal antimicrobial defense in a mouse model of postoperative ileus. PLoS One. 2018; 13(4): e0195516.","DOI":"10.1371\/journal.pone.0195516"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Minnone, G, De Benedetti, F, Bracci-Laudiero, L. NGF and its receptors in the regulation of inflammatory response. Int J Mol Sci. 2017; 18(5): E1028.","DOI":"10.3390\/ijms18051028"},{"key":"25","doi-asserted-by":"publisher","unstructured":"25. Oikawa, T, Ito, G, Koyama, H, Hanawa, T. Prokinetic effect of a Kampo medicine, Hange-koboku-to (Banxia-houpo-tang), on patients with functional dyspepsia. Phytomedicine. 2005; 12(10): 730\u20134.","DOI":"10.1016\/j.phymed.2005.03.001"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Ohama, T, Hori, M, Momotani, E, Elorza, M, Gerthoffer, WT, Ozaki, H. IL-1beta inhibits intestinal smooth muscle proliferation in an organ culture system: involvement of COX-2 and iNOS induction in muscularis resident macrophages. Am J Physiol Gastrointest Liver Physiol. 2007; 292(5): G1315\u201322.","DOI":"10.1152\/ajpgi.00487.2006"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Naito, Y, Takagi, T, Uchiyama, K, Kuroda, M, Kokura, S, Ichikawa, H, et al. Reduced intestinal inflammation induced by dextran sodium sulfate in interleukin-6-deficient mice. Int J Mol Med. 2004; 14(2): 191\u20136.","DOI":"10.3892\/ijmm.14.2.191"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Reinshagen, M, Rohm, H, Steinkamp, M, Lieb, K, Geerling, I, Von Herbay, A, et al. Protective role of neurotrophins in experimental inflammation of the rat gut. Gastroenterology. 2000; 119(2): 368\u201376.","DOI":"10.1053\/gast.2000.9307"},{"key":"29","doi-asserted-by":"publisher","unstructured":"29. Barada, KA, Mourad, FH, Sawah, SI, Khoury, C, Safieh-Garabedian, B, Nassar, CF, et al. Up-regulation of nerve growth factor and interleukin-10 in inflamed and non-inflamed intestinal segments in rats with experimental colitis. Cytokine. 2007; 37(3): 236\u201345.","DOI":"10.1016\/j.cyto.2007.04.005"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Ma, D, Wolvers, D, Stanisz, AM, Bienenstock, J. Interleukin-10 and nerve growth factor have reciprocal upregulatory effects on intestinal epithelial cells. Am J Physiol Regul Integr Comp Physiol. 2003; 284(5): R1323\u20139.","DOI":"10.1152\/ajpregu.00756.2002"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Zhang, XN, Chen, DZ, Zheng, YH, Liang, JG, Yang, HX, Lin, XW, et al. Gene transfer of calcitonin gene-related peptide suppresses development of allograft vasculopathy. Transplant Proc. 2009; 41(5): 1900\u20135.","DOI":"10.1016\/j.transproceed.2008.12.038"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Wang, H, Xing, L, Li, W, Hou, L, Guo, J, Wang, X. Production and secretion of calcitonin gene-related peptide from human lymphocytes. J Neuroimmunol. 2002; 130(1-2): 155\u201362.","DOI":"10.1016\/S0165-5728(02)00221-7"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Davis, RL, Sanchez, AC, Lindley, DJ, Williams, SC, Syapin, PJ. Effects of mechanistically distinct NF-kappaB inhibitors on glial inducible nitric-oxide synthase expression. Nitric Oxide. 2005; 12(4): 200\u20139.","DOI":"10.1016\/j.niox.2005.04.005"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Prencipe, G, Minnone, G, Strippoli, R, De Pasquale, L, Petrini, S, Caiello, I, et al. Nerve growth factor downregulates inflammatory response in human monocytes through TrkA. J Immunol. 2014; 192(7): 3345\u201354.","DOI":"10.4049\/jimmunol.1300825"}],"container-title":["Journal of Smooth Muscle Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jsmr\/58\/0\/58_0535\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T04:27:16Z","timestamp":1715315236000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jsmr\/58\/0\/58_0535\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":34,"journal-issue":{"issue":"0","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.1540\/jsmr.58.78","relation":{},"ISSN":["0916-8737","1884-8796"],"issn-type":[{"value":"0916-8737","type":"print"},{"value":"1884-8796","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]},"article-number":"0535"}}