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Colokinetic            effect of noradrenaline in the spinal defecation center: implication for motility            disorders. Sci Rep. 2015;            5(28): 12623.","DOI":"10.1038\/srep12623"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Howorth,                PW,                Teschemacher,                AG,                Pickering,                AE.            Retrograde adenoviral vector targeting of nociresponsive pontospinal            noradrenergic neurons in the rat in vivo. J Comp          Neurol. 2009; 512(2):            141\u201357.","DOI":"10.1002\/cne.21879"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Millan,              MJ. Descending            control of pain. Prog Neurobiol. 2002;            66(6): 355\u2013474.","DOI":"10.1016\/S0301-0082(02)00009-6"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Jones,              SL,                Light,              AR.            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