{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T19:07:14Z","timestamp":1785179234747,"version":"3.55.0"},"reference-count":39,"publisher":"Japan Society of Smooth Muscle Research","issue":"0","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Smooth Muscle Res","J. Smooth Muscle Res."],"published-print":{"date-parts":[[2023]]},"DOI":"10.1540\/jsmr.59.34","type":"journal-article","created":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T22:11:38Z","timestamp":1688595098000},"page":"34-57","source":"Crossref","is-referenced-by-count":2,"title":["&lt;i&gt;Garcinia buchananii&lt;\/i&gt; stem bark extract and its bioactive          constituents manniflavanone, GB-2 and buchananiflavanone attenuate intestinal inhibitory          neuromuscular transmission"],"prefix":"10.1540","volume":"59","author":[{"given":"Savannah","family":"Patterson","sequence":"first","affiliation":[{"name":"Department of Biological Sciences\/WWAMI, University of Idaho, 875            Perimeter Drive, LSS 252, Moscow, ID 83844, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Elder","family":"Waters","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences\/WWAMI, University of Idaho, 875            Perimeter Drive, LSS 252, Moscow, ID 83844, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Braman","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences\/WWAMI, University of Idaho, 875            Perimeter Drive, LSS 252, Moscow, ID 83844, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roan","family":"Willson","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences\/WWAMI, University of Idaho, 875            Perimeter Drive, LSS 252, Moscow, ID 83844, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney A.","family":"Hill","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, Charles Sturt University,            Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Magolan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biomedical Sciences, McMaster            University, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Hofmann","sequence":"additional","affiliation":[{"name":"Chair of Food Chemistry and Molecular Sensory Science, Technische            Universit\u00e4t M\u00fcnchen, Lise-Meitner Str. 34, 85354 Freising, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo D.","family":"Stark","sequence":"additional","affiliation":[{"name":"Chair of Food Chemistry and Molecular Sensory Science, Technische            Universit\u00e4t M\u00fcnchen, Lise-Meitner Str. 34, 85354 Freising, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Onesmo B.","family":"Balemba","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences\/WWAMI, University of Idaho, 875            Perimeter Drive, LSS 252, Moscow, ID 83844, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"435","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Jones,              SL,                Blikslager,                AT. Role of            the enteric nervous system in the pathophysiology of secretory diarrhea.            J Vet Intern Med. 2002;            16(3): 222\u20138.","DOI":"10.1111\/j.1939-1676.2002.tb02361.x"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Camilleri,                M,                Nullens,              S,                Nelsen,              T.            Enteroendocrine and neuronal mechanisms in pathophysiology of acute            infectious diarrhea. Dig Dis Sci. 2012;            57(1): 19\u201327.","DOI":"10.1007\/s10620-011-1939-9"},{"key":"3","doi-asserted-by":"publisher","unstructured":"3. Yuan,              H,                Ma,              Q,                Ye,              L,                Piao,              G. The            traditional medicine and modern medicine from natural products.            Molecules. 2016; 21(5):            559.","DOI":"10.3390\/molecules21050559"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Maroyi,              A. Treatment of            diarrhoea using traditional medicines: contemporary research in South Africa and            Zimbabwe. Afr J Tradit Complement Altern Med.            2016; 13(6):            5\u201310.","DOI":"10.21010\/ajtcam.v13i6.2"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Balemba,                OB,                Bhattarai,                Y,                Stenkamp-Strahm,                C,                Lesakit,                MSB,                Mawe,              GM. The            traditional antidiarrheal remedy, <i>Garcinia buchananii<\/i> stem bark            extract, inhibits propulsive motility and fast synaptic potentials in the guinea pig            distal colon. Neurogastroenterol Motil.            2010; 22(12):            1332\u20139.","DOI":"10.1111\/j.1365-2982.2010.01583.x"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Galligan,                JJ,                Sternini,              C. Insights            into the role of opioid receptors in the GI tract: experimental evidence and therapeutic            relevance. Handb Exp Pharmacol. 2017;            239: 363\u201378.","DOI":"10.1007\/164_2016_116"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Boakye,              PA,                Brierley,                SM,                Pasilis,              SP,                Balemba,              OB.              <i>Garcinia buchananii<\/i> bark extract is an effective            anti-diarrheal remedy for lactose-induced diarrhea. J            Ethnopharmacol. 2012; 142(2):            539\u201347.","DOI":"10.1016\/j.jep.2012.05.034"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Brierley,                SM,                Castro,              J,                Balemba,              O,                Blackshaw,                L.              <i>Garcinia buchananii<\/i> bark extract inhibits nociceptors,            with greater efficacy during inflammation.            Gastroenterology. 2011; 140:            S-866.","DOI":"10.1016\/S0016-5085(11)63596-8"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Stark,              TD,                Matsutomo,                T,                L\u00f6sch,              S,                Boakye,              PA,                Balemba,              OB,                Pasilis,              SP, et al.          Isolation and structure elucidation of highly antioxidative 3,8\u2033-linked            biflavanones and flavanone-C-glycosides from <i>Garcinia buchananii<\/i>            bark. J Agric Food Chem. 2012;            60(8): 2053\u201362.","DOI":"10.1021\/jf205175b"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Stark,              TD,                Salger,              M,                Frank,              O,                Balemba,              OB,                Wakamatsu,                J,                Hofmann,              T.            Antioxidative compounds from <i>Garcinia buchananii<\/i> stem            bark. J Nat Prod. 2015;            78(2): 234\u201340.","DOI":"10.1021\/np5007873"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Stark,              TD,                L\u00f6sch,              S,                Frank,              O,                Balemba,              OB,                Hofmann,              T. Purification            procedure for (2R,3S,2\u2033R,3\u2033R)-manniflavanone and its minor (2R,3S,2\u2033S,3\u2033S)-isomer from              <i>Garcinia buchananii<\/i> stem bark. Eur Food Res            Technol. 2015; 240:            1075\u201380.","DOI":"10.1007\/s00217-014-2411-9"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Balemba,                OB,                Stark,              TD,                L\u00f6sch,              S,                Patterson,                S,                McMillan,                JS,                Mawe,              GM, et al.          (2R,3S,2\u2032\u2019 R,3\u2032\u2019R)-manniflavanone, a new gastrointestinal smooth muscle            L-type calcium channel inhibitor, which underlies the spasmolytic properties of Garcinia            buchananii stem bark extract. J Smooth Muscle Res.            2014; 50: 48\u201365.","DOI":"10.1540\/jsmr.50.48"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Matsuda,                NM,                Miller,              SM,                Sha,              L,                Farrugia,              G,                Szurszewski,                JH. Mediators            of non-adrenergic non-cholinergic inhibitory neurotransmission in porcine            jejunum. Neurogastroenterol Motil. 2004;            16(5): 605\u201312.","DOI":"10.1111\/j.1365-2982.2004.00574.x"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Mart\u00ednez-Cutillas,                M,                Gil,              V,                Gallego,              D,                Ma\u00f1\u00e9,              N,                Clav\u00e9,              P,                Mart\u00edn,              MT, et al.          \u03b1,\u03b2-meATP mimics the effects of the purinergic neurotransmitter in the            human and rat colon. Eur J Pharmacol.          2014; 740: 442\u201354.","DOI":"10.1016\/j.ejphar.2014.06.048"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Gallego,              D,                Malagelada,                C,                Accarino,              A,                De Giorgio,                R,                Malagelada,                JR,                Azpiroz,              F, et al.          Nitrergic and purinergic mechanisms evoke inhibitory neuromuscular            transmission in the human small intestine. Neurogastroenterol            Motil. 2014; 26(3):            419\u201329.","DOI":"10.1111\/nmo.12293"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Fern\u00e1ndez,                E,                Guo,              X,                Vergara,              P,                Jim\u00e9nez,              M. Evidence            supporting a role for ATP as non-adrenergic non-cholinergic inhibitory transmitter in            the porcine ileum. Life Sci. 1998;            62(15): 1303\u201315.","DOI":"10.1016\/S0024-3205(98)00064-2"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Hwang,              SJ,                Blair,              PJ,                Durnin,              L,                Mutafova-Yambolieva,                V,                Sanders,              KM,                Ward,              SM. P2Y1            purinoreceptors are fundamental to inhibitory motor control of murine colonic            excitability and transit. J Physiol. 2012;            590(8): 1957\u201372.","DOI":"10.1113\/jphysiol.2011.224634"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Spencer,                NJ,                Smith,              TK.            Simultaneous intracellular recordings from longitudinal and circular            muscle during the peristaltic reflex in guinea-pig distal colon.            J Physiol. 2001; 533(Pt          3): 787\u201399.","DOI":"10.1111\/j.1469-7793.2001.00787.x"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Yang,              Z,                Pan,              A,                Zuo,              W,                Guo,              J,                Zhou,              W. Relaxant            effect of flavonoid naringenin on contractile activity of rat colonic smooth            muscle. J Ethnopharmacol. 2014;            155(2): 1177\u201383.","DOI":"10.1016\/j.jep.2014.06.053"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Wood,              MJ,                Hyman,              NH,                Mawe,              GM. The effects            of daikenchuto (DKT) on propulsive motility in the colon. J Surg            Res. 2010; 164(1):            84\u201390.","DOI":"10.1016\/j.jss.2009.03.068"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Brown,              DR,                Timmermans,                JP. Lessons            from the porcine enteric nervous system. Neurogastroenterol            Motil. 2004; 16(Suppl          1): 50\u20134.","DOI":"10.1111\/j.1743-3150.2004.00475.x"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Jager,              LP,                van der Schaar,                MWG.            Characterization of inhibitory innervation in porcine colonic circular            muscle. Can J Physiol Pharmacol. 1988;            66(11): 1386\u201397.","DOI":"10.1139\/y88-227"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Boakye,              PA,                Stenkamp-Strahm,                C,                Bhattarai,                Y,                Heckman,              MD,                Brierley,                SM,                Pasilis,              SP, et al.          5-HT(3) and 5-HT(4) receptors contribute to the anti-motility effects of              <i>Garcinia buchananii<\/i> bark extract in the guinea-pig distal            colon. Neurogastroenterol Motil. 2012;            24(1): e27\u201340.","DOI":"10.1111\/j.1365-2982.2011.01807.x"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Bhattarai,                Y,                Fried,              D,                Gulbransen,                B,                Kadrofske,                M,                Fernandes,                R,                Xu,              H, et al.          High-fat diet-induced obesity alters nitric oxide-mediated neuromuscular            transmission and smooth muscle excitability in the mouse distal colon.            Am J Physiol Gastrointest Liver Physiol. 2016;            311(2): G210\u201320.","DOI":"10.1152\/ajpgi.00085.2016"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Burnstock,                G,                Campbell,              G,                Satchell,              D,                Smythe,              A. Evidence            that adenosine triphosphate or a related nucleotide is the transmitter substance            released by non-adrenergic inhibitory nerves in the gut. Br J            Pharmacol. 1970; 40(4):            668\u201388.","DOI":"10.1111\/j.1476-5381.1970.tb10646.x"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Nyavor,              Y,                Estill,              R,                Edwards,              H,                Ogden,              H,                Heideman,              K,                Starks,              K, et al.          Intestinal nerve cell injury occurs prior to insulin resistance in female            mice ingesting a high-fat diet. Cell Tissue Res.            2019; 376(3):            325\u201340.","DOI":"10.1007\/s00441-019-03002-0"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Gallego,              D,                Gil,              V,                Aleu,              J,                Martinez-Cutillas,                M,                Clav\u00e9,              P,                Jim\u00e9nez,              M.            Pharmacological characterization of purinergic inhibitory neuromuscular            transmission in the human colon. Neurogastroenterol            Motil. 2011; 23(8):            792\u2013e338.","DOI":"10.1111\/j.1365-2982.2011.01725.x"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Stark,              TD,                Germann,              D,                Balemba,              OB,                Wakamatsu,                J,                Hofmann,              T. New highly            in vitro antioxidative 3,8\u2033-linked Biflav(an)ones and Flavanone-C-glycosides from              <i>Garcinia buchananii<\/i> stem bark. J Agric Food            Chem. 2013; 61(51):            12572\u201381.","DOI":"10.1021\/jf404783y"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Matsuyama,                H,                Tanahashi,                Y,                Kitazawa,              T,                Yamada,              M,                Komori,              S,                Unno,              T. Evidence for            M2 and M3 muscarinic receptor involvement in cholinergic excitatory junction potentials            through synergistic activation of cation channels in the longitudinal muscle of mouse            ileum. J Pharmacol Sci. 2013;            121(3): 227\u201336.","DOI":"10.1254\/jphs.12231FP"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Tanahashi,                Y,                Komori,              S,                Matsuyama,                H,                Kitazawa,              T,                Unno,              T. Functions of            muscarinic receptor subtypes in gastrointestinal smooth muscle: A review of studies with            receptor-knockout mice. Int J Mol Sci.            2021; 22(2): 926.","DOI":"10.3390\/ijms22020926"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Matsui,              M,                Motomura,              D,                Fujikawa,              T,                Jiang,              J,                Takahashi,                S,                Manabe,              T, et al.          Mice lacking M2 and M3 muscarinic acetylcholine receptors are devoid of            cholinergic smooth muscle contractions but still viable. J            Neurosci. 2002; 22(24):            10627\u201332.","DOI":"10.1523\/JNEUROSCI.22-24-10627.2002"},{"key":"32","unstructured":"32. Roth,                BL. National Institute of          Mental Health Psychoactive Drug Screening Program (NIMH PDSP) Assay Protocol Book Version          III. 2018."},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Zizzo,              MG,                Mul\u00e8,              F,                Serio,              R. Evidence            that ATP or a related purine is an excitatory neurotransmitter in the longitudinal            muscle of mouse distal colon. Br J Pharmacol.            2007; 151(1):            73\u201381.","DOI":"10.1038\/sj.bjp.0707188"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Wang,              Q,                Zang,              J,                Huang,              X,                Lu,              H,                Xu,              W,                Chen,              J. Colonic            dysmotility in murine partial colonic obstruction due to functional changes in            interstitial cells. J Neurogastroenterol Motil.            2019; 25(4):            589\u2013601.","DOI":"10.5056\/jnm19136"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Kurahashi,                M,                Mutafova-Yambolieva,                V,                Koh,              SD,                Sanders,              KM.            Platelet-derived growth factor receptor-\u03b1-positive cells and not smooth            muscle cells mediate purinergic hyperpolarization in murine colonic            muscles. Am J Physiol Cell Physiol. 2014;            307(6): C561\u201370.","DOI":"10.1152\/ajpcell.00080.2014"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Bornstein,                JC,                Costa,              M,                Grider,              JR. Enteric            motor and interneuronal circuits controlling motility.            Neurogastroenterol Motil. 2004;            16(Suppl 1):            34\u20138.","DOI":"10.1111\/j.1743-3150.2004.00472.x"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Xu,                F,                Proft,              J,                Gibbs,              S,                Winkfein,              B,                Johnson,              JN,                Syed,              N, et al.          Quercetin targets cysteine string protein (CSPalpha) and impairs synaptic            transmission. PLoS One. 2010;            5(6): e11045.","DOI":"10.1371\/journal.pone.0011045"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Million,              M,                Larauche,              M. Stress, sex,            and the enteric nervous system. Neurogastroenterol            Motil. 2016; 28(9):            1283\u20139.","DOI":"10.1111\/nmo.12937"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Panche,              AN,                Diwan,              AD,                Chandra,              SR. Flavonoids:            an overview. J Nutr Sci. 2016;            5: e47.","DOI":"10.1017\/jns.2016.41"}],"container-title":["Journal of Smooth Muscle Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jsmr\/59\/0\/59_0537\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,8]],"date-time":"2023-07-08T05:00:15Z","timestamp":1688792415000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jsmr\/59\/0\/59_0537\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":39,"journal-issue":{"issue":"0","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.1540\/jsmr.59.34","relation":{},"ISSN":["0916-8737","1884-8796"],"issn-type":[{"value":"0916-8737","type":"print"},{"value":"1884-8796","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]},"article-number":"0537"}}