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Keller,              J,                Bassotti,              G,                Clarke,              J,                Dinning,              P,                Fox,              M,                Grover,              M, et al.          International Working Group for Disorders of Gastrointestinal Motility and            Function.          Expert consensus document: advances in the diagnosis and classification of            gastric and intestinal motility disorders. Nat Rev Gastroenterol            Hepatol. 2018; 15(5):            291\u2013308.","DOI":"10.1038\/nrgastro.2018.7"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Ziyang,              JK,                Kuo,              B. Insights            into functional dyspepsia and gastroparesis\u2014Western versus Asian            perspectives. J Neurogastroenterol Motil.            2025; 31(4):            407\u201321.","DOI":"10.5056\/jnm24181"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Kar,              P,                Jones,              KL,                Horowitz,              M,                Chapman,              MJ,                Deane,              AM. Measurement            of gastric emptying in the critically ill. Clin Nutr.            2015; 34(4):            557\u201364.","DOI":"10.1016\/j.clnu.2014.11.003"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Sanaka,              M,                Kuyama,              Y,                Yamanaka,              M. Guide for            judicious use of the paracetamol absorption technique in a study of gastric emptying            rate of liquids. J Gastroenterol. 1998;            33(6): 785\u201391.","DOI":"10.1007\/s005350050177"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Sanaka,              M,                Nakada,              K. Stable            isotope breath tests for assessing gastric emptying: a comprehensive            review. J Smooth Muscle Res. 2010;            46(6): 267\u201380.","DOI":"10.1540\/jsmr.46.267"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Jalleh,              RJ,                Marathe,              CS,                Rayner,              CK,                Jones,              KL,                Umapathysivam,                MM,                Wu,              T, et al.          Physiology and pharmacology of effects of GLP-1-based therapies on gastric,            biliary and intestinal motility. Endocrinology.            2024; 166(1): bqae155.","DOI":"10.1210\/endocr\/bqae155"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Hiramoto,                B,                McCarty,              TR,                Lodhia,              NA,                Jenkins,              A,                Elnaiem,              A,                Muftah,              M, et al.          Quantified metrics of gastric emptying delay by glucagon-like peptide-1            agonists: a systematic review and meta-analysis with insights for periprocedural            management. Am J Gastroenterol. 2024;            119(6): 1126\u201340.","DOI":"10.14309\/ajg.0000000000002820"},{"key":"8","unstructured":"8. Maurer,              AH.            Gastrointestinal motility, part 1: esophageal transit and gastric            emptying. J Nucl Med. 2015;            56(8): 1229\u201338."},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Goyal,              RK,                Guo,              Y,                Mashimo,              H. Advances in            the physiology of gastric emptying. Neurogastroenterol            Motil. 2019; 31(4):            e13546.","DOI":"10.1111\/nmo.13546"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Spiller,              R,                Marciani,              L. Intraluminal            impact of food: new insights from MRI. Nutrients.            2019; 11(5): 1147.","DOI":"10.3390\/nu11051147"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Ziessman,                HA,                Okolo,              PI,                Mullin,              GE,                Chander,              A. Liquid            gastric emptying is often abnormal when solid emptying is normal.            J Clin Gastroenterol. 2009;            43(7): 639\u20134.","DOI":"10.1097\/MCG.0b013e318181b42f"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Ziessman,                HA,                Chander,              A,                Clarke,              JO,                Ramos,              A,                Wahl,              RL. The added            diagnostic value of liquid gastric emptying compared with solid emptying            alone. J Nucl Med. 2009;            50(5): 726\u201331.","DOI":"10.2967\/jnumed.108.059790"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Hay,              PD,                Corsetti,              M,                Tucker,              E,                Fox,              MR,                Perkins,              A.            Tolerability, gastric emptying patterns, and symptoms during the            Nottingham Test Meal in 330 secondary care non-diabetic dyspeptic            patients. Neurogastroenterol Motil. 2022;            34(12): e14454.","DOI":"10.1111\/nmo.14454"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Neubauer,                L,                Bartels,              S,                Mankertz,              F,                Voit,              D,                Frahm,              J,                Weitschies,                W, et al.          Isocaloric liquid and solid meals induce comparable postprandial gastric            motility: Implications for oral drug delivery assessed by real-time MRI.            Int J Pharm X. 2026; 11:            100557.","DOI":"10.1016\/j.ijpx.2026.100557"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Collins,                PJ,                Horowitz,              M,                Cook,              DJ,                Harding,              PE,                Shearman,                DJC. Gastric            emptying in normal subjects\u2014a reproducible technique using a single scintillation camera            and computer system. Gut. 1983;            24(12): 1117\u201325.","DOI":"10.1136\/gut.24.12.1117"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Siegel,              JA,                Krevsky,              B,                Maurer,              AH,                Charkes,              ND,                Fisher,              RS,                Malmud,              LS.            Scintigraphic evaluation of gastric emptying: are radiolabeled solids            necessary?          Clin Nucl Med. 1989; 14(1):            40\u20136.","DOI":"10.1097\/00003072-198901000-00011"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Siegel,              JA,                Urbain,              JL,                Adler,              LP,                Charkes,              ND,                Maurer,              AH,                Krevsky,              B, et al.          Biphasic nature of gastric emptying. Gut.            1988; 29(1):            85\u20139.","DOI":"10.1136\/gut.29.1.85"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Horowitz,                M,                Maddox,              AF,                Wishart,              JM,                Harding,              PE,                Chatterton,                BE,                Shearman,                DJC.            Relationships between oesophageal transit and solid and liquid gastric            emptying in diabetes mellitus. Eur J Nucl Med.            1991; 18(4):            229\u201334.","DOI":"10.1007\/BF00186645"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Ziessman,                HA,                Fahey,              FH,                Collen,              MJ. Biphasic            solid and liquid gastric emptying in normal controls and diabetics using continuous            acquisition in LAO view. Dig Dis Sci.          1992; 37(5):            744\u201350.","DOI":"10.1007\/BF01296433"},{"key":"20","unstructured":"20. Jones,              KL,                Horowitz,              M,                Wishart,              MJ,                Maddox,              AF,                Harding,              PE,                Chatterton,                BE.            Relationships between gastric emptying, intragastric meal distribution            and blood glucose concentrations in diabetes mellitus. J Nucl            Med. 1995; 36(12):            2220\u20138."},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Sachdeva,                P,                Malhotra,              N,                Pathikonda,                M,                Khayyam,              U,                Fisher,              RS,                Maurer,              AH, et al.          Gastric emptying of solids and liquids for evaluation for            gastroparesis. Dig Dis Sci. 2011;            56(4): 1138\u201346.","DOI":"10.1007\/s10620-011-1635-9"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Sachdeva,                P,                Kantor,              S,                Knight,              LC,                Maurer,              AH,                Fisher,              RS,                Parkman,              HP. Use of a            high caloric liquid meal as an alternative to a solid meal for gastric emptying            scintigraphy. Dig Dis Sci. 2013;            58(7): 2001\u20136.","DOI":"10.1007\/s10620-013-2665-2"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Camilleri,                M,                Shin,              A. Novel and            validated approaches for gastric emptying scintigraphy in patients with suspected            gastroparesis. Dig Dis Sci. 2013;            58(7): 1813\u20135.","DOI":"10.1007\/s10620-013-2715-9"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Jian,              R,                Ducrot,              F,                Piedeloup,                C,                Mary,              JY,                Najean,              Y,                Bernier,              JJ. Measurement            of gastric emptying in dyspeptic patients: effect of a new gastrokinetic agent            (cisapride). Gut. 1985;            26(4): 352\u20138.","DOI":"10.1136\/gut.26.4.352"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Petring,                OU,                Blake,              DW. Gastric            emptying in adults: an overview related to anaesthesia. Anaesth            Intensive Care. 1993; 21(6):            774\u201381.","DOI":"10.1177\/0310057X9302100605"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Medhus,              AW,                Bj\u00f8rnland,                K,                Emblem,              R,                Husebye,              E. Liquid and            solid gastric emptying in adults treated for Hirschsprung\u2019s disease during early            childhood. Scand J Gastroenterol. 2007;            42(1): 34\u201340.","DOI":"10.1080\/00365520600842211"},{"key":"27","unstructured":"27. Urso,              R,                Blardi,              P,                Giorgi,              G. A short            introduction to pharmacokinetics. Eur Rev Med Pharmacol            Sci. 2002; 6(2\u20133):            33\u201344."},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Willems,              M,                Quartero,                AO,                Numans,              ME. How useful            is paracetamol absorption as a marker of gastric emptying? A systematic literature            study. Dig Dis Sci. 2001;            46(10): 2256\u201362.","DOI":"10.1023\/A:1011935603893"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Janse,              RJ,                Hoekstra,              T,                Jager,              KJ,                Zoccali,              C,                Tripepi,              G,                Dekker,              FW, et al.          Conducting correlation analysis: important limitations and            pitfalls. Clin Kidney J. 2021;            14(11): 2332\u20137.","DOI":"10.1093\/ckj\/sfab085"},{"key":"30","unstructured":"30. Rowland,              M,                Tozer,              TN. Clinical pharmacokinetics:          Concepts and applications. 3rd ed. Baltimore: Williams & Wilkins; 1995.          11p."},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Forrest,                JAH,                Clements,                JA,                Prescott,                LF. Clinical            pharmacokinetics of paracetamol. Clin Pharmacokinet.            1982; 7(2):            93\u2013107.","DOI":"10.2165\/00003088-198207020-00001"},{"key":"32","doi-asserted-by":"publisher","unstructured":"32. Brener,              W,                Hendrix,              TR,                McHugh,              PR. Regulation            of the gastric emptying of glucose. Gastroenterology.            1983; 85(1):            76\u201382.","DOI":"10.1016\/S0016-5085(83)80232-7"},{"key":"33","unstructured":"33. Flanagan,                RJ,                Brown,              NW. Whelpton.            Therapeutic drug monitoring. Clin Biochem.            2008; 9:          3\u201321."},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Sanaka,              M,                Kuyama,              Y,                Shimomura,                Y,                Saitoh,              M,                Hattori,              K. New            mathematical model for accurate description of absorption kinetics of paracetamol given            orally with a high calorie liquid meal. Int J Clin Pharmacol            Ther. 2002; 40(11):            499\u2013506.","DOI":"10.5414\/CPP40499"},{"key":"35","unstructured":"35. Jambhekar,                SS,                Breen,              PJ. Basic Pharmacokinetics.          2nd ed. London: Pharmaceutical Press; 1994. 106p."},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Clements,                JA,                Heading,              RC,                Nimmo,              WS,                Prescott,                LF. Kinetics            of acetaminophen absorption and gastric emptying in man. Clin            Pharmacol Ther. 1978; 24(4):            420\u201331.","DOI":"10.1002\/cpt1978244420"},{"key":"37","unstructured":"37. Sanaka,              M,                Koike,              Y,                Yamamoto,              T,                Mineshita,                S,                Yamaoka,              S,                Hirama,              S, et al.          A reliable and convenient parameter of the rate of paracetamol absorption            to measure gastric emptying rate of liquids. Int J Clin            Pharmacol Ther. 1997; 35(11):            509\u201313."},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Koyama,              K,                Sasaki,              I,                Naito,              H,                Tsuchiya,              T,                Funayama,              Y,                Shibata,              C, et al.          [Gastric emptying of semi-solid meal in normal man with special reference            to relationship between plasma acetoaminophen concentrations and gastric emptying            time]. J Smooth Muscle Res. 1995;            31(2): 61\u20135          (in Japanese with English abstract).","DOI":"10.1540\/jsmr.31.61"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Sanaka,              M,                Kuyama,              Y,                Nishinakagawa,                S,                Mineshita,                S. Use of            salivary acetaminophen concentration to assess gastric emptying rate of            liquids. J Gastroenterol. 2000;            35(6): 429\u201333.","DOI":"10.1007\/s005350070087"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Sanaka,              M,                Kuyama,              Y,                Shimomura,                Y,                Qi,              JF,                Okamura,              S,                Hao,              Y, et al.          Gastric emptying of liquids is delayed by co-ingesting solids: a study            using salivary paracetamol concentrations. J            Gastroenterol. 2002; 37(10):            785\u201390.","DOI":"10.1007\/s005350200131"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Maddern,              G,                Miners,              J,                Collins,              PJ,                Jamieson,                GG. Liquid            gastric emptying assessed by direct and indirect techniques: radionuclide labelled            liquid emptying compared with a simple paracetamol marker method.            Aust N Z J Surg. 1985;            55(2): 203\u20136.","DOI":"10.1111\/j.1445-2197.1985.tb00885.x"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Gandia,              P,                Bareille,                MP,                Saivin,              S,                Le-Traon,                AP,                Lavit,              M,                Guell,              A, et al.          Influence of simulated weightlessness of acetaminophen as a gastric            emptying probe in man: a plasma and a saliva study. J Clin            Pharmacol. 2003; 43:            1235\u201343.","DOI":"10.1177\/0091270003257229"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Danhof,              M,                Breimer,              DD. Therapeutic            drug monitoring in saliva. Clin Pharmacokinet.            1978; 3(1):            39\u201357.","DOI":"10.2165\/00003088-197803010-00003"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44. Nakano,              M,                Nakano,              N,                Funada,              S,                Iwasaki,              K. Correlation            between salivary and plasma levels of acetaminophen. Jpn J Clin            Pharmacol Ther.          1988; 19: 549\u201353.","DOI":"10.3999\/jscpt.19.549"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45. Kamali,              F,                Fry,              JR,                Bell,              GD. Salivary            secretion of paracetamol in man. J Pharm Pharmacol.            1987; 39(2):            150\u20132.","DOI":"10.1111\/j.2042-7158.1987.tb06967.x"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46. Adithan,              C,                Thangam,              J. A            comparative study of saliva and serum paracetamol levels using a simple            spectrophotometric method. Br J Clin Pharmacol.            1982; 14(1):            107\u20139.","DOI":"10.1111\/j.1365-2125.1982.tb04944.x"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47. Smith,              M,                Whitehead,                E,                O\u2019Sullivan,                G,                Reynolds,              F. A comparison            of serum and saliva paracetamol concentrations. Br J Clin            Pharmacol. 1991; 31(5):            553\u20135.","DOI":"10.1111\/j.1365-2125.1991.tb05580.x"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48. Kamali,              F,                Edwards,              C,                Rawlins,              MD. The effect            of pirenzepine on gastric emptying and salivary flow rate: constraints on the use of            saliva paracetamol concentrations for the determination of paracetamol            pharmacokinetics. Br J Clin Pharmacol.            1992; 33(3):            309\u201312.","DOI":"10.1111\/j.1365-2125.1992.tb04041.x"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49. Shibata,              C,                Sawada,              K,                Mitamura,              A,                Nakano,              T. Gastric            emptying after distal gastrectomy from physiologic viewpoint: accelerated or            delayed?          J Smooth Muscle Res. 2025; 61:            20\u20138.","DOI":"10.1540\/jsmr.61.20"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50. Johansson,                UB,                Eskils,              J,                Adamson,              U,                Elwin,              CE,                Wredling,              R,                Lins,              PE. A            paracetamol-pasta test for assessing gastric emptying in healthy and diabetic            subjects. Scand J Clin Lab Invest. 2003;            63(2): 159\u201366.","DOI":"10.1080\/00365510310000330"},{"key":"51","doi-asserted-by":"crossref","unstructured":"51. Kachi,              M,                Shirasaka,                D,                Aoyama,              N,                Ebara,              S,                Miki,              I,                Morita,              Y, et al.          Effects of Helicobacter pylori eradication therapy on gastric emptying            measured using the 13C-octanoic acid breath test and the acetaminophen            method. J Gastroenterol Hepatol. 2006;            21(5): 824\u201330.","DOI":"10.1111\/j.1440-1746.2006.04075.x"},{"key":"52","doi-asserted-by":"crossref","unstructured":"52. Shirasaka,                D,                Kachi,              M,                Aoyama,              N. Comparison            of the gastric emptying results among the 13C-octanoic acid breath tests, scintigraphy,            and acetaminophen method. J Smooth Muscle Res.            2002; 6: J-107\u201313          (in Japanese with English abstract).","DOI":"10.1540\/heikatsukinzashi1997.6.J107"},{"key":"53","doi-asserted-by":"crossref","unstructured":"53. Medhus,              AW,                Sandstad,              O,                Bredesen,              J,                Husebye,              E. Delay of            gastric emptying by duodenal intubation: sensitive measurement of gastric emptying by            the paracetamol absorption test. Aliment Pharmacol          Ther. 1999; 13(5):            609\u201320.","DOI":"10.1046\/j.1365-2036.1999.00519.x"},{"key":"54","unstructured":"54. van                Wyk, M,                Sommers,              DK,                Meyer,              EC,                Moncrieff,                J. The mean            cumulative fraction absorbed-time profiles of paracetamol as an index of gastric            emptying. Methods Find Exp Clin Pharmacol.            1990; 12(4):            291\u20134."},{"key":"55","unstructured":"55. van                Wyk, M,                Sommers,              DK,                Snyman,              JR,                Moncrieff,                J. A            foreshortened method of measuring liquid gastric emptying in normal            volunteers. Methods Find Exp Clin Pharmacol.            1993; 15(1):            61\u20136."},{"key":"56","doi-asserted-by":"crossref","unstructured":"56. Sanaka,              M,                Nakada,              K. Paracetamol            absorption test with Wagner-Nelson analysis for safe and accurate measurements of            gastric emptying in women. Methods Find Exp Clin            Pharmacol. 2008; 30(10):            753\u20136.","DOI":"10.1358\/mf.2008.30.10.1316828"},{"key":"57","doi-asserted-by":"crossref","unstructured":"57. Sharma,              CV,                Mehta,              V. Paracetamol:            mechanisms and updates. BJA Educ. 2014;            14: 153\u20138.","DOI":"10.1093\/bjaceaccp\/mkt049"},{"key":"58","doi-asserted-by":"crossref","unstructured":"58. Mucklow,                JC,                Fraser,              HS,                Bulpitt,              CJ,                Kahn,              C,                Mould,              G,                Dollery,              CT.            Environmental factors affecting paracetamol metabolism in London factory            and office workers. Br J Clin Pharmacol.            1980; 10(1):            67\u201374.","DOI":"10.1111\/j.1365-2125.1980.tb00503.x"},{"key":"59","doi-asserted-by":"crossref","unstructured":"59. Rorat,              MJ,                Szyma\u0144ski,                W,                Zi\u0144czuk,              A. To use or            not to use: Safety of selected painkillers in patients with chronic liver            diseases. Clin Exp Hepatol. 2025;            11(2): 113\u201320.","DOI":"10.5114\/ceh.2025.151745"},{"key":"60","doi-asserted-by":"crossref","unstructured":"60. Holt,              S,                Heading,              RC,                Clements,                JA,                Tothill,              P,                Prescott,                LF.            Acetaminophen absorption and metabolism in celiac disease and Crohn\u2019s            disease. 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