{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T20:10:09Z","timestamp":1748635809487,"version":"3.41.0"},"reference-count":0,"publisher":"Romanian Society of Gastroenterology and Hepatology","issue":"1","license":[{"start":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T00:00:00Z","timestamp":1743033600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JGLD"],"abstract":"<jats:p>Background and Aims: To explore the prognostic role of programmed cell death-ligand 1 (PD-L1) in patients with gastrointestinal stromal tumours (GISTs).\r\nMethods: PD-L1 expression was detected using immunohistochemistry in tissue microarrays from 96 GISTs samples. Survival of patients was assessed using Kaplan \u2013 Meier analysis. Possible risk factors for GISTs were explored using Cox proportional hazards regression models. The role of PD-L1 in GISTs proliferation, invasion, and metastasis was assessed using colony formation assay, scratch, transwell invasion, and migration assays.\r\nResults: Survival in GISTs patients was significantly associated with PD-L1 expression (p &lt; 0.05). High PD-L1 expression in GISTs resulted in relatively short overall survival (p=0.016). Univariate regression analysis showed that PD-L1 was a risk factor for poor prognosis (p&lt;0.05). Compared with the control group, knockdown of PD-L1 significantly decreased the colony formation rate, and cell migration and invasion were inhibited compared with the control group. The wound healing ability of PD-L1 knockdown group was significantly weaker than that of the control group.\r\nConclusions: The results suggest that overexpression of PD-L1 is a risk factor for a poor prognosis in patients with GISTs. Knockdown of PD-L1 significantly inhibited the development of GISTs. PD-L1 may serve as a biomarker for the poor prognosis of GISTs and a potential therapeutic target.<\/jats:p>","DOI":"10.15403\/jgld-5858","type":"journal-article","created":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T10:35:41Z","timestamp":1743158141000},"page":"30-39","source":"Crossref","is-referenced-by-count":0,"title":["Programmed Cell Death-ligand 1 as Biomarker of Poor Prognosis in Patients with Gastrointestinal Stromal Tumour"],"prefix":"10.15403","volume":"34","author":[{"given":"Duolikun","family":"Yasheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abuduwaili","family":"Aierken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiliang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aikebaier","family":"Aili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelimu","family":"Abudureyimu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6121","published-online":{"date-parts":[[2025,3,27]]},"container-title":["Journal of Gastrointestinal and Liver Diseases"],"original-title":[],"link":[{"URL":"https:\/\/www.jgld.ro\/jgld\/index.php\/jgld\/article\/download\/5858\/2164","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.jgld.ro\/jgld\/index.php\/jgld\/article\/download\/5858\/2164","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T19:31:47Z","timestamp":1748633507000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jgld.ro\/jgld\/index.php\/jgld\/article\/view\/5858"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,27]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,3,28]]}},"URL":"https:\/\/doi.org\/10.15403\/jgld-5858","relation":{},"ISSN":["1842-1121","1841-8724"],"issn-type":[{"type":"electronic","value":"1842-1121"},{"type":"print","value":"1841-8724"}],"subject":[],"published":{"date-parts":[[2025,3,27]]}}}