{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T17:03:38Z","timestamp":1775754218734,"version":"3.50.1"},"reference-count":0,"publisher":"Romanian Society of Gastroenterology and Hepatology","issue":"4","license":[{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JGLD"],"abstract":"<jats:p>Background and Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) with the prevalence of around 25% is the most prevailing cause of chronic liver disease. In this study, we aimed to investigate the association of the rs16928751 or +795 G&gt;A variant in adiponectin receptor 2 gene (ADIPOR2) with MASLD.\nMethods: Genomic DNA was isolated from the whole blood of 130 patients with biopsy-confirmed MASLD, and 130 controls according to the phenol-chloroform extraction and ethanol precipitation approach. Then the polymorphic marker of +795 G&gt;A was genotyped by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).\nResults: The +795 G&gt;A variant met the Hardy-Weinberg equilibrium (p &gt; 0.05) in both control and patient groups; hence, the samples had good population representativeness. The genotype count of ADIPOR2 gene +795 G&gt;A differed significantly between these two groups. The +795 G&gt;A \u201eAA\u201d genotype in comparison to the \u201eGG\u201d was more frequent in the patients with MASLD (p=0. 037; OR=2.24, 95%CI: 1.20\u20136.47).\nConclusions: To our knowledge, this study is the first one that found a significant association between the +795 G&gt;A variant of the ADIPOR2 gene and biopsy-confirmed MASLD; nonetheless, it needs to be corroborated by further research in different populations.<\/jats:p>","DOI":"10.15403\/jgld-6326","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T17:47:14Z","timestamp":1766771234000},"page":"451-456","source":"Crossref","is-referenced-by-count":1,"title":["The Association of the Polymorphic Marker of +795 G&gt;A in the Adiponectin Receptor 2 Gene with Biopsy-confirmed Metabolic Dysfunction-associated Steatotic Liver Disease"],"prefix":"10.15403","volume":"34","author":[{"given":"Kosar","family":"Babaeian Roshani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Ourang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitra","family":"Rostami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atefeh","family":"Dehghanitafti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mobina","family":"Hosseini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Touraj","family":"Mahmoudi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronak","family":"Soltanirazlighi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aidin","family":"Mahban","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radmehr","family":"Shafiee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helia Sadat","family":"Kaboli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gholamreza","family":"Rezamand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asadollah","family":"Asadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Dabiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seidamir Pasha","family":"Tabaeian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6121","published-online":{"date-parts":[[2025,12,26]]},"container-title":["Journal of Gastrointestinal and Liver Diseases"],"original-title":[],"link":[{"URL":"https:\/\/jgld.ro\/jgld\/index.php\/jgld\/article\/download\/6326\/2254","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jgld.ro\/jgld\/index.php\/jgld\/article\/download\/6326\/2254","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T17:47:14Z","timestamp":1766771234000},"score":1,"resource":{"primary":{"URL":"https:\/\/jgld.ro\/jgld\/index.php\/jgld\/article\/view\/6326"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,26]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,12,26]]}},"URL":"https:\/\/doi.org\/10.15403\/jgld-6326","relation":{},"ISSN":["1842-1121","1841-8724"],"issn-type":[{"value":"1842-1121","type":"electronic"},{"value":"1841-8724","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12,26]]}}}