{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T21:02:06Z","timestamp":1791061326567,"version":"4.1.0"},"reference-count":0,"publisher":"Romanian Society of Gastroenterology and Hepatology","issue":"1","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JGLD"],"abstract":"<jats:p>Background and Aims: Helicobacter pylori (H. pylori) infection remains a major public health problem in Asia, with high prevalence and increasing therapeutic resistance. Vonoprazan (VPZ), a potassium-competitive acid blocker, combined with amoxicillin is thought to improve eradication rates in first-line therapy. This study evaluated the efficacy of VPZ with amoxicillin as first-line therapy for H. pylori eradication in an Asian population.\nMethods: A systematic review and meta-analysis of clinical studies was conducted according to PRISMA guidelines. A literature search was conducted in PubMed and ScienceDirect through September 2025. Data related to the eradication rate (ER) of VPZ-amoxicillin and the comparison of VPZ-amoxicillin eradication with proton pump inhibitors (PPIs) were extracted and analyzed. Data were analyzed using a random-effects model with the main effect sizes being ER and risk difference (RD), as well as meta-regression against age and body mass index (BMI). Data analysis was performed using RevMan 5.4 and R software.\nResults: This study included 22 clinical studies with 32 comparisons involving 7,498 participants. The VPZ-amoxicillin combination in dual, triple, and quadruple therapy regimens had ERs of 0.92 (95%CI: 0.90-0.95); 0.93 (95%CI: 0.91-0.95); and 0.96 (95%CI: 0.93-0.99), respectively, for a total eradication rate of 0.94 (95%CI: 0.91-0.96). Comparison with PPIs showed a risk difference of 0.06 (95%CI: 0.02-0.09) overall and 0.03 (95%CI: -0.02-0.08); 0.07 (95%CI: 0.02-0.12) and 0.04 (95%CI: 0-0.07) in dual, triple, and quadruple therapy, respectively. Meta-regression showed that age (p=0.006) influenced therapy effectiveness, but BMI (p=0.411) did not.\nConclusion: Vonoprazan with amoxicillin is effective as first-line therapy for H. pylori eradication in the Asian population.<\/jats:p>","DOI":"10.15403\/jgld-6600","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T22:52:48Z","timestamp":1774565568000},"page":"91-99","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of Vonoprazan with Amoxicillin as the First Line Therapy for Helicobacter pylori Eradication in Asian Population: A Systematic Review, Meta-Analysis, and Meta-Regression of Clinical Studies"],"prefix":"10.15403","volume":"35","author":[{"given":"I Made Suma","family":"Wirawan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I Gede Eka","family":"Handrean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6121","published-online":{"date-parts":[[2026,3,27]]},"container-title":["Journal of Gastrointestinal and Liver Diseases"],"original-title":[],"link":[{"URL":"https:\/\/jgld.ro\/jgld\/index.php\/jgld\/article\/download\/6600\/2300","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jgld.ro\/jgld\/index.php\/jgld\/article\/download\/6600\/2301","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jgld.ro\/jgld\/index.php\/jgld\/article\/download\/6600\/2300","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T22:52:48Z","timestamp":1774565568000},"score":1,"resource":{"primary":{"URL":"https:\/\/jgld.ro\/jgld\/index.php\/jgld\/article\/view\/6600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,27]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,3,27]]}},"URL":"https:\/\/doi.org\/10.15403\/jgld-6600","relation":{},"ISSN":["1842-1121","1841-8724"],"issn-type":[{"value":"1842-1121","type":"electronic"},{"value":"1841-8724","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3,27]]}}}