{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T15:59:26Z","timestamp":1790438366443,"version":"4.1.0"},"reference-count":0,"publisher":"Romanian Society of Gastroenterology and Hepatology","issue":"3","license":[{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JGLD"],"abstract":"<jats:p>Background and Aims: Underwater endoscopic mucosal resection (U-EMR) and conventional endoscopic mucosal resection (C-EMR) are the primary techniques for the removal of colorectal polyps. The purpose of this study is to conduct a meta-analysis on the safety and efficacy of the two procedures, U-EMR and C-EMR.\nMethods: We searched multiple databases for randomized controlled trials (RCTs) comparing U-EMR and C-EMR for the resection of sessile or flat colorectal polyps. Standard meta-analytic methods were employed using random-effects, and I\u00b2 % was used to assess heterogeneity.\nResults: A total of seven RCTs were included. Regarding the en bloc resection rate, U-EMR was superior to C-EMR [Risk Ratio (RR) 1.13, 95% confidence interval (CI): 1.02\u20131.24]. Subgroup analysis showed that the higher en bloc resection rate of U-EMR was mainly manifested in 10-20 mm polyps (RR=1.16, 95%CI: 1.07-1.25). In the analysis of R0 resection rate, U-EMR outperformed C-EMR (RR=1.28, 95%CI: 1.02\u20131.61). In terms of the incidence of adverse events and recurrence rate, U-EMR showed a trend lower than C-EMR in terms of intraoperative bleeding [odds ratio (OR) 0.83, 95%CI: 0.45-1.54), delayed bleeding (OR=0.61, 95%CI: 0.28-1.32), and recurrence rate (OR=0.53, 95%CI: 0.24-1.18), but none of them reached statistical significance. For procedure time, U-EMR demonstrated shorter resection times than C-EMR [mean difference (MD) \u20133.05 minutes, 95%CI: \u20135.17 to \u20130.92).\nConclusions: For sessile or flat colorectal polyps measuring \u226510 mm in diameter, U-EMR demonstrates superior efficacy compared with C-EMR.<\/jats:p>","DOI":"10.15403\/jgld-6825","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T15:12:39Z","timestamp":1784301159000},"page":"445-454","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Outcomes of Underwater versus Conventional Endoscopic Mucosal Resection in the Removal of Sessile or Flat Colorectal Polyps \u226510 mm: A Systematic Review and Meta-Analysis of Randomized Controlled Trials"],"prefix":"10.15403","volume":"35","author":[{"given":"Yiheng","family":"Yao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfeng","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingjie","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxing","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6121","published-online":{"date-parts":[[2026,7,17]]},"container-title":["Journal of Gastrointestinal and Liver Diseases"],"original-title":[],"link":[{"URL":"https:\/\/jgld.ro\/jgld\/index.php\/jgld\/article\/download\/6825\/2364","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jgld.ro\/jgld\/index.php\/jgld\/article\/download\/6825\/2363","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T15:22:42Z","timestamp":1790436162000},"score":1,"resource":{"primary":{"URL":"https:\/\/jgld.ro\/jgld\/index.php\/jgld\/article\/view\/6825"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,17]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,9,26]]}},"URL":"https:\/\/doi.org\/10.15403\/jgld-6825","relation":{},"ISSN":["1842-1121","1841-8724"],"issn-type":[{"value":"1842-1121","type":"electronic"},{"value":"1841-8724","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7,17]]}}}