{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T08:05:54Z","timestamp":1771920354077,"version":"3.50.1"},"reference-count":16,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,10,1]]},"abstract":"\n Objective:<\/jats:title>\n La Crosse infection, caused by a rare mosquito-transmitted virus, is endemic in Western North Carolina. Given the large number of cases at our institution, our goal was to describe the presentation, management, and clinical course for pediatric patients with this disease.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n We retrospectively reviewed medical records from pediatric patients with antibody-confirmed La Crosse infection admitted to Mission Hospital July 2004 through August 2009. Demographics, clinical characteristics, management methods, length of hospital stay, and complications were analyzed. Regression analysis was used to assess relationships between presentation and clinical course.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Forty-seven pediatric patients were identified with antibody-confirmed La Crosse infection. Seventy percent were male, and the median age was 8 years. Admission signs and symptoms included fever (43%), headache (94%), vomiting (78%), altered mental status (58%), and seizures (61%). All patients had pleocytosis on cerebrospinal fluid studies (range 10\u20131063 cells\/mm3). Median length of stay was 5 days. Seizure at admission was associated with an increased length of stay (2.4 additional days, 95% confidence interval 0.7\u20134.1). Eighteen patients (38%) received intensive care, 7 (19%) received parenteral or enteral (via nasogastric tube) nutrition, and 4 (9%) received mechanical ventilation. No statistically significant associations between presenting signs and symptoms and complications were found. Treatments included antibiotics (87%), antiviral medication (55%), seizure prophylaxis (47%), and isotonic fluids (98%).<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Our data reflect few indicators to predict clinical course during hospital stay. Management strategies should include attention to development of seizure activity and preventive measures for syndrome of inappropriate antidiuretic hormone.<\/jats:p>\n <\/jats:sec>","DOI":"10.1542\/hpeds.2012-0022","type":"journal-article","created":{"date-parts":[[2013,9,27]],"date-time":"2013-09-27T17:50:08Z","timestamp":1380304208000},"page":"235-242","source":"Crossref","is-referenced-by-count":64,"title":["La Crosse Viral Infection in Hospitalized Pediatric Patients in Western North Carolina"],"prefix":"10.1542","volume":"2","author":[{"given":"Ansley","family":"Miller","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Mission Hospital, Asheville, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Carchman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Mission Hospital, Asheville, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Long","sequence":"additional","affiliation":[{"name":"Public Health Epidemiology, Infection Prevention, Mission Hospital, Asheville, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheri A.","family":"Denslow","sequence":"additional","affiliation":[{"name":"Public Health Epidemiology, Infection Prevention, Mission Hospital, Asheville, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2012,10,1]]},"reference":[{"issue":"30","key":"2021120817352680100_B1","first-page":"1009","article-title":"West Nile virus disease and other arboviral diseases\u2013United States, 2010","volume":"60","author":"Centers for Disease Control and Prevention (CDC)","year":"2011","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"2021120817352680100_B2","article-title":"ArboNET: National surveillance system for arboviral diseases in the United States","author":"Centers for Disease Control and Prevention, Division of Vector-Borne Infectious Diseases, National Center for Zoonotic, Vector-Borne, and Enteric Diseases, in conjunction with local and state health departments"},{"key":"2021120817352680100_B3","unstructured":"Centers for Disease Control and Prevention. Informational sheet on La Crosse Encephalitis. Available at: www.cdc.gov\/lac\/. Accessed October 31, 2011."},{"issue":"5","key":"2021120817352680100_B4","doi-asserted-by":"crossref","first-page":"509","DOI":"10.4269\/ajtmh.2003.69.509","article-title":"Economic and social impacts of La Crosse encephalitis in western North Carolina","volume":"69","author":"Utz","year":"2003","journal-title":"Am J Trop Med Hyg"},{"issue":"11","key":"2021120817352680100_B5","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1093\/aje\/155.11.1060","article-title":"La Crosse encephalitis in Eastern Tennessee: clinical, environmental, and entomological characteristics from a blinded cohort study","volume":"155","author":"Erwin","year":"2002","journal-title":"Am J Epidemiol"},{"issue":"2","key":"2021120817352680100_B6","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1177\/0883073807307984","article-title":"Periodic lateralized epileptiform discharges in La Crosse encephalitis, a worrisome subgroup: clinical presentation, electroencephalogram (EEG) patterns, and long-term neurologic outcome","volume":"23","author":"de los Reyes","year":"2008","journal-title":"J Child Neurol"},{"key":"2021120817352680100_B7","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1471-2334-11-29","article-title":"The spatial epidemiology and clinical features of reported cases of La Crosse virus infection in West Virginia from 2003 to 2007","volume":"11","author":"Haddow","year":"2011","journal-title":"BMC Infect Dis"},{"issue":"7","key":"2021120817352680100_B8","doi-asserted-by":"crossref","first-page":"e6145","DOI":"10.1371\/journal.pone.0006145","article-title":"The incidence risk, clustering, and clinical presentation of La Crosse virus infections in the eastern United States, 2003-2007","volume":"4","author":"Haddow","year":"2009","journal-title":"PLoS ONE"},{"issue":"8","key":"2021120817352680100_B9","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/S0196-6553(03)00084-1","article-title":"Clinical comparisons of La Crosse encephalitis and enteroviral central nervous system infections in a pediatric population: 2001 surveillance in East Tennessee","volume":"31","author":"Hardin","year":"2003","journal-title":"Am J Infect Control"},{"issue":"11","key":"2021120817352680100_B10","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1056\/NEJM200103153441103","article-title":"La Crosse encephalitis in children","volume":"344","author":"McJunkin","year":"2001","journal-title":"N Engl J Med"},{"key":"2021120817352680100_B11"},{"issue":"2","key":"2021120817352680100_B12","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1542\/peds.105.2.316","article-title":"Cerebrospinal fluid findings in aseptic versus bacterial meningitis","volume":"105","author":"Negrini","year":"2000","journal-title":"Pediatrics"},{"issue":"5","key":"2021120817352680100_B13","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0887-8994(03)00003-1","article-title":"Absolute neutrophil count in aseptic and bacterial meningitis related to time of lumbar puncture","volume":"28","author":"Straussberg","year":"2003","journal-title":"Pediatr Neurol"},{"issue":"9","key":"2021120817352680100_B14","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1001\/archneur.1979.00500450075016","article-title":"Value of second lumbar puncture in confirming a diagnosis of aseptic meningitis. A prospective study","volume":"36","author":"Varki","year":"1979","journal-title":"Arch Neurol"},{"issue":"10","key":"2021120817352680100_B15","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1097\/INF.0b013e31821c922c","article-title":"Safety and pharmacokinetics of ribavirin for the treatment of la crosse encephalitis","volume":"30","author":"McJunkin","year":"2011","journal-title":"Pediatr Infect Dis J"},{"issue":"3","key":"2021120817352680100_B16","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1863-2378.2011.01433.x","article-title":"La Crosse encephalitis surveillance using single versus paired serologic testing","volume":"59","author":"Murphree","year":"2012","journal-title":"Zoonoses Public Health"}],"container-title":["Hospital Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/hospitalpediatrics\/article-pdf\/2\/4\/235\/840072\/hpeds_2012-0022.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/hospitalpediatrics\/article-pdf\/2\/4\/235\/840072\/hpeds_2012-0022.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T18:13:26Z","timestamp":1638987206000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/hospitalpediatrics\/article\/2\/4\/235\/26098\/La-Crosse-Viral-Infection-in-Hospitalized"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,1]]},"references-count":16,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2012,10,1]]},"published-print":{"date-parts":[[2012,10,1]]}},"URL":"https:\/\/doi.org\/10.1542\/hpeds.2012-0022","relation":{},"ISSN":["2154-1663","2154-1671"],"issn-type":[{"value":"2154-1663","type":"print"},{"value":"2154-1671","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,1]]}}}