{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T20:57:21Z","timestamp":1767992241521,"version":"3.49.0"},"reference-count":22,"publisher":"American Academy of Pediatrics (AAP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,5,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>To determine the incidence with which a vancomycin dosing regimen of 15 mg\/kg per dose every 6 hours achieves steady-state trough concentrations of 15 to 20 mg\/L in pediatric patients with complicated infections.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>We performed a retrospective chart review for patients admitted to our children\u2019s hospital between July 1, 2009, and June 30, 2011. Patients were included if they were between 1 month and 18 years of age, had at least 1 steady-state vancomycin trough obtained, received an initial vancomycin dose of 15 mg\/kg per dose every 6 hours, and were being treated for a diagnosis of meningitis, pneumonia, osteomyelitis, bacteremia\/sepsis, or endocarditis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>Seventy-four patients were enrolled, mean age of 4.2 \u00b1 3.9 years and weight of 17.0 \u00b1 11.2 kg. Five (6.8%) patients obtained an initial trough of 15 to 20 mg\/L. Patients between 1.0 and 5.9 years of age were significantly less likely to achieve an initial trough of 15 to 20 mg\/L compared with other age groups evaluated (P = .041). Thirty-four patients with initial subtherapeutic troughs received a dose adjustment and a follow-up vancomycin trough. Of these patients, 15 (44.1%) achieved a trough between 15 and 20 mg\/L. The median dose for patients achieving a therapeutic trough at any point during the study was 80 mg\/kg per day.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>A vancomycin dosing regimen of 15 mg\/kg per dose every 6 hours is not likely to achieve a trough concentration of 15 to 20 mg\/L in pediatric patients with complicated infections. An initial regimen of 80 mg\/kg per day for these patients may be more likely to result in therapeutic steady-state concentrations of vancomycin.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/hpeds.2014-0081","type":"journal-article","created":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T08:11:18Z","timestamp":1430467878000},"page":"276-281","source":"Crossref","is-referenced-by-count":23,"title":["An Evaluation of Vancomycin Dosing for Complicated Infections in Pediatric Patients"],"prefix":"10.1542","volume":"5","author":[{"given":"Spencer H.","family":"Durham","sequence":"first","affiliation":[{"name":"Auburn University Harrison School of Pharmacy, Auburn, Alabama;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marroyln L.","family":"Simmons","sequence":"additional","affiliation":[{"name":"St. Joseph\u2019s Children\u2019s Hospital, Tampa, Florida;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana 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