{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T14:10:34Z","timestamp":1793369434537,"version":"4.5.0"},"reference-count":13,"publisher":"American Academy of Pediatrics (AAP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,6,1]]},"abstract":"\n OBJECTIVE:<\/jats:title>\n Pediatric acute hematogenous osteomyelitis (AHO) is a relatively common reason for hospitalization, but many variables require additional study, including the impact of antibiotic treatment on bone biopsy culture yield.<\/jats:p>\n <\/jats:sec>\n \n METHODS:<\/jats:title>\n This was a retrospective study of children 60 days to 18 years old with AHO seen from 2011 to 2012 in whom bone biopsy cultures were obtained.<\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n A total of 67 children had biopsies; median age was 7 years; 40 were pretreated with antibiotics. Microbiologic confirmation was obtained for 72%: in 34%, both blood and bone cultures were positive; in 33%, bone cultures alone were positive; and 4% had only positive blood cultures. There was no difference in bone biopsy cultures for children who did and did not receive antibiotics before biopsy (28\/40 [70%] vs 17\/27 [63%], odds ratio 1.37, 95% confidence interval 0.49\u20133.86). For pretreated patients, the mean duration of therapy was longer in children with negative cultures (79 vs 40 hours, P = .04). Bacteremia was seen in 26 (39%), and was more common in antibiotic-pretreated children (55% vs 15%, odds ratio 7, 95% confidence interval 2.1\u201324.1). Among the 41 nonbacteremic children, bone cultures provided the only microbiologic diagnosis for 22 (54%): 20 Staphylococcus aureus, 2 Streptococcus pyogenes.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n In conclusion, although bone biopsy results were not affected by previous antibiotic administration, a longer duration of antibiotic therapy before bone biopsy was associated with lower culture yield. In one-third of children, only the bone biopsy resulted in an organism being isolated. As it may take longer to sterilize bone than blood, a bone biopsy\/culture should be considered a crucial part of the AHO evaluation to increase diagnostic yield.<\/jats:p>\n <\/jats:sec>","DOI":"10.1542\/hpeds.2014-0114","type":"journal-article","created":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T08:20:48Z","timestamp":1433146848000},"page":"337-341","source":"Crossref","is-referenced-by-count":42,"title":["Impact of Antibiotic Pretreatment on Bone Biopsy Yield for Children With Acute Hematogenous Osteomyelitis"],"prefix":"10.1542","volume":"5","author":[{"given":"Derek J.","family":"Zhorne","sequence":"first","affiliation":[{"name":"Sections of Hospital Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E.","family":"Altobelli","sequence":"additional","affiliation":[{"name":"Sections of Hospital Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea 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