{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T21:36:33Z","timestamp":1792532193100,"version":"4.5.0"},"reference-count":33,"publisher":"American Academy of Pediatrics (AAP)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,7,1]]},"abstract":"<jats:sec><jats:title>OBJECTIVES:<\/jats:title><jats:p>Varicella is a disease with potentially severe complications. We aimed to investigate characteristics of hospitalized children with varicella in Brazil in the prevaccine period and to identify predictors for requiring intensive care treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>A prospective cohort study was conducted from May 2011 to April 2014. Patients up to 13 years of age with varicella diagnosis were included. Information was collected through interview and review of medical records. Logistic regression analysis was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>A total of 669 patients were admitted. The median age of subjects was 2.7 years (range 0\u201314 years) with a predominance of boys (56.6%). The main causes of hospitalization were bacterial complications (77.7%), viral complications (11.4%), and at-risk patients (10.9%). Main bacterial complications were skin infection and pneumonia. Main viral complications were herpes zoster, cerebellitis, and encephalitis. Most at-risk patients used corticosteroids or had a diagnosis of leukemia. At-risk patients were hospitalized earlier (P &amp;lt; .01) and remained hospitalized for longer periods (P = .03). A total of 44 patients (6.6%) were admitted to the ICU, and 5 (0.8%) died of septic shock. Thrombocytopenia was associated with more severe illness in patients with bacterial infections (P = .001). The long-time interval between onset of infection and admission was associated with the need for intensive care in all groups (P = .007).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>Secondary bacterial infection is the main cause of hospitalization, and thrombocytopenia in these patients leads to worse outcomes. Difficulties of access to the health system and delay in medical care are determining factors of greater severity in this population.<\/jats:p><\/jats:sec>","DOI":"10.1542\/hpeds.2017-0086","type":"journal-article","created":{"date-parts":[[2018,7,2]],"date-time":"2018-07-02T08:28:03Z","timestamp":1530520083000},"page":"419-425","source":"Crossref","is-referenced-by-count":18,"title":["Study of Complications of Varicella-Zoster Virus Infection in Hospitalized Children at a Reference Hospital for Infectious Disease Treatment"],"prefix":"10.1542","volume":"8","author":[{"given":"Lilian Martins Oliveira","family":"Diniz","sequence":"first","affiliation":[{"name":"School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelle Marie Martins","family":"Maia","sequence":"additional","affiliation":[{"name":"School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yara Vieira de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina Santos Falci","family":"Mour\u00e3o","sequence":"additional","affiliation":[{"name":"School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda Vieira","family":"Couto","sequence":"additional","affiliation":[{"name":"School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e2nia Carneiro","family":"Mota","sequence":"additional","affiliation":[{"name":"School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina Mazieiro","family":"Versiani","sequence":"additional","affiliation":[{"name":"School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscila Ol\u00edvia da Costa","family":"Silveira","sequence":"additional","affiliation":[{"name":"School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta Maia Castro","family":"Romanelli","sequence":"additional","affiliation":[{"name":"School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2018,7,1]]},"reference":[{"issue":"1","key":"2021120817294866200_B1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1542\/pir.29-1-5","article-title":"Varicella-zoster virus infections","volume":"29","author":"Gershon","year":"2008","journal-title":"Pediatr Rev"},{"key":"2021120817294866200_B2","first-page":"856","article-title":"Varicella-zoster infections","volume-title":"Red Book: 2015 Report of the Committee on Infectious Disease","author":"American Academy of Pediatrics","year":"2015","edition":"30th ed"},{"issue":"12","key":"2021120817294866200_B3","doi-asserted-by":"crossref","first-page":"e52016","DOI":"10.1371\/journal.pone.0052016","article-title":"Time trends in pediatric hospitalizations for varicella infection are associated with climatic changes: a 22-year retrospective study in a tertiary Greek referral center","volume":"7","author":"Critselis","year":"2012","journal-title":"PLoS One"},{"key":"2021120817294866200_B4","volume-title":"Informe T\u00e9cnico de Introdu\u00e7\u00e3o da vacina tetra viral. 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