{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T12:24:01Z","timestamp":1794313441691,"version":"4.9.0"},"reference-count":17,"publisher":"American Academy of Pediatrics (AAP)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,1]]},"abstract":"<jats:sec>\n                  <jats:title>BACKGROUND AND OBJECTIVES<\/jats:title>\n                  <jats:p>Data on invasive bacterial infection (IBI), defined as bacteremia and\/or bacterial meningitis, in febrile infants aged &amp;lt;60 days old primarily derive from smaller, dated studies conducted at large, university-affiliated medical centers. Our objective with the current study was to determine current prevalence and epidemiology of IBI from a contemporary, national cohort of well-appearing, febrile infants at university-affiliated and community-based hospitals.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>PATIENTS AND METHODS<\/jats:title>\n                  <jats:p>Retrospective review of well-appearing, febrile infants aged 7 to 60 days was performed across 31 community-based and 44 university-affiliated centers from September 2015 to December 2017. Blood and cerebrospinal fluid bacterial culture results were reviewed and categorized by using a priori criteria for pathogenic organisms. Prevalence estimates and subgroup comparisons were made by using descriptive statistics.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>A total of 10\u2009618 febrile infants met inclusion criteria; cerebrospinal fluid and blood cultures were tested from 6747 and 10\u2009581 infants, respectively. Overall, meningitis prevalence was 0.4% (95% confidence interval [CI]: 0.2\u20130.5); bacteremia prevalence was 2.4% (95% CI: 2.1\u20132.7). Neonates aged 7 to 30 days had significantly higher prevalence of bacteremia, as compared with infants in the second month of life. IBI prevalence did not differ between community-based and university-affiliated hospitals (2.7% [95% CI: 2.3\u20133.1] vs 2.1% [95% CI: 1.7\u20132.6]). Escherichia coli and Streptococcus agalactiae were the most commonly identified organisms.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>This contemporary study of well-appearing, febrile infants supports previous epidemiological estimates of IBI prevalence and suggests that the prevalence of IBI may be similar among community-based and university-affiliated hospitals. These results can be used to aid future clinical guidelines and prediction tool development.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/hpeds.2020-002147","type":"journal-article","created":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T09:26:29Z","timestamp":1630488389000},"page":"e184-e188","source":"Crossref","is-referenced-by-count":19,"title":["Prevalence of Invasive Bacterial Infections in Well-Appearing, Febrile Infants"],"prefix":"10.1542","volume":"11","author":[{"given":"Russell J.","family":"McCulloh","sequence":"first","affiliation":[{"name":"Children's Hospital and Medical Center, Omaha, Nebraska"},{"name":"Department of Pediatrics, University of Nebraska Medical Center, Omaha, Nebraska"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren M.","family":"McDaniel","sequence":"additional","affiliation":[{"name":"Johns Hopkins Children\u2019s Center, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Kerns","sequence":"additional","affiliation":[{"name":"Children's Hospital and Medical Center, Omaha, Nebraska"},{"name":"Department of Pediatrics, University of Nebraska Medical Center, Omaha, Nebraska"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric A.","family":"Biondi","sequence":"additional","affiliation":[{"name":"Johns Hopkins Children\u2019s Center, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2021,9,1]]},"reference":[{"issue":"3","key":"2021121007573991100_b1","doi-asserted-by":"crossref","first-page":"e190874","DOI":"10.1001\/jamanetworkopen.2019.0874","article-title":"Prevalence of bacteremia and bacterial meningitis in febrile neonates and infants in the second month of life: a systematic review and meta-analysis","volume":"2","author":"Biondi","year":"2019","journal-title":"JAMA Netw 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